Biochemical assessment of oxidative stress by the use of açai (Euterpe oleracea Martius) gel in physically active individuals

Viana, Daniela Soares; Carvalho, Lucía María Jaeger de; Moura, Mirian Ribeiro Leite; Peixoto, Jacqueline Carvalho; Carvalho, J. L. V. de

doi:10.1590/1678-457x.0046

Cited by 6 publications

(14 citation statements)

References 15 publications

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“…A number of studies have demonstrated that the chemical composition of açai fruit confers it with valuable antioxidant and anti-inflammatory properties, and it seems likely that these compounds produce a protective effect in the brain of the PbA-infected mice fed with açai-enriched ration [ 49 – 52 ]. While additional studies need to be done to ratify this hypothesis, several works have shown that oral intake of açai decreases the level of IL-1β, IL-18 and TNF-α, prevents the production of thiobarbituric acid reactive substance (TBARS) and modulates antioxidant enzymes such as superoxide dismutase (SOD) and catalase [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Euterpe oleracea fruit (Açai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection

Oliveira¹,

Torres²,

Kauffmann³

et al. 2022

BMC Complement Med Ther

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Background Cerebral malaria is one of the most severe complications attributed to protozoal infection by Plasmodium falciparum, gaining prominence in children mortality rates in endemic areas. This condition has a complex pathogenesis associated with behavioral, cognitive and motor sequels in humans and current antimalarial therapies have shown little effect in those aspects. Natural products with antioxidant and anti-inflammatory properties have become a valuable alternative therapeutic option in the treatment of distinct conditions. In this context, this study investigated the neuroprotective effect of Euterpe oleracea (açai) enriched diet during the development of experimental cerebral malaria induced by the inoculation of Swiss albino mice with Plasmodium berghei ANKA strain. Methods After Plasmodium infection, animals were maintained on a feeding with Euterpe oleracea enriched ration and parameters such as survival curve, parasitemia and body weight were routinely monitored. The present study has also evaluated the effect of açai-enriched diet on the blood-brain barrier leakage, histological alterations and neurocognitive impairments in mice developing cerebral malaria. Results Our results demonstrate that between 7th–19th day post infection the survival rate of the group treated with açai enriched ration was higher when compared with Plasmodium-infected mice in which 100% of mice died until the 11th days post-infection, demonstrating that açai diet has a protective effect on the survival of infected treated animals. The same was observed in the brain vascular extravasation, where Evans blue dye assays showed significantly less dye extravasation in the brains of Plasmodium-infected mice treated with açai enriched ration, demonstrating more preserved blood-brain barrier integrity. Açai-enriched diet also attenuate the histopathological alterations elicited by Plasmodium berghei infection. We also showed a decrease of the neurological impairments arising from the exposure of cerebral parenchyma in the group treated with açai diet, ameliorating motor and neuropsychiatric changes, analyzed through the SHIRPA protocol. Conclusion With these results, we conclude that the treatment with açai enriched ration decreased the mortality of infected animals, as well as protected the blood-brain barrier and the neurocognitive deficits in Plasmodium-infected animals.

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Section: Discussionmentioning

confidence: 99%

Euterpe oleracea fruit (Açai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection

Oliveira¹,

Torres²,

Kauffmann³

et al. 2022

BMC Complement Med Ther

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“…Viana et al 12 realizaram um ensaio clínico que avaliou os efeitos da ingestão regular, durante três dias consecutivos, de um gel produzido partir da polpa do açaí. Como resultados, a ingestão do gel desenvolvido reduziu o estresse muscular, medido por meio da redução da CK, LDH, alanina aminotransferase (GPT), bem como alterou as concentrações de glutationa peroxidase (GPx).…”

Section: Discussionunclassified

“…Os fitoquímicos mais relevantes presentes na polpa do açaí são as antocianinas 3,12,16 , principal composto responsável pelo efeito antioxidante do açaí 3,16 , proantocianidina e compostos fenólicos, como ácidos fenólicos, flavanóis, flavonóis e outros flavonóides 3,16 , como a quercetina, catequina, epicatecna, rutina e astolbina 16 . Sobre as antocianinas, são pigmentos hidrossolúveis, que proporcionam a cor vermelha escura do açaí 16,28 , que têm a maior capacidade antioxidante entre seus flavonóides.…”

Section: Discussionunclassified

“…O acúmulo dos radicais livres e o estresse oxidativo trazem consigo diversas consequências, como por exemplo: elevação dos níveis de peroxidação, causando mau funcionamento de membranas celulares 1,2 ; obstrução da função ou lesões ao esqueleto celular 2 ; disfunção do sistema imune; danos à organelas como a mitocôndria 3 , e ao DNA 2,3,5 , aumentando a propensão a tumores e cânceres 2,3 ; mudança na estrutura e função ou até desnaturação de proteínas 2,5 ; inibição da contractilidade em fibras musculares 2 ; e agravo de estados como diabetes mellitus tipo 2 5 , envelhecimento 3,5,11 , inflamações 12 , doenças cardiovasculares 3 . Estudos ainda estabelecem uma relação entre a elevação na produção de EROs com a disposição do processo de fadiga muscular e/ou processo de lesão muscular 1,11 .…”

Section: Introductionunclassified

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Efeitos da suplementação crônica de açaí sobre danos musculares em corredores de rua

et al. 2018

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O exercício físico aeróbio eleva o volume de oxigênio consumido e, consequentemente, de espécies reativas de oxigênio. O acúmulo destas culmina em estresse oxidativo, e a susceptibilidade a danos musculares. O açaí contém elevadas concentrações de antioxidantes, responsáveis por reduzir o estresse oxidativo. Esse estudo objetivou avaliar o efeito do consumo crônico de açaí sobre o dano muscular de corredores de rua. 14 corredores homens foram randomicamente divididos em grupos açaí (200g diários) ou controle, durante 25 dias. Foram avaliados, no período pré (M1) e pós intervenção (M2), marcador de dano muscular (CK) em repouso, imediatamente e 24h após corrida, percepção subjetiva do esforço (PSE) e antropometria. No M1, houve elevações significativas de CK após o exercício (0h e 24h) em ambos os grupos, sem haver diferença entre eles. Após a intervenção, observou-se redução significativa da CK 24h no grupo que recebeu açaí, em relação ao M1, demonstrando que o consumo crônico de açaí preveniu danos musculares. Não houve diferença significativa acerca dos dados antropométricos e a PSE entre ambos os momentos e grupos. Conclui-se que suplementação de açaí reduziu significativamente a CK de corredores de rua em prova de 10km, porém, sem alterar a PSE e a composição corporal.

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“…All studies were published from the year 2014 onwards. In the articles with humans, the majority of authors are from Brazil (n=5) [26][27][28][29][30] and only one article is from Poland (n=1). Regarding the characteristics of the participants, only men were included, aged between 16 and 48 years.…”

Section: Characteristics Of Human Experimental Studiesmentioning

confidence: 99%

Effect of açai supplementation (Euterpe Oleracea Mart.) associated with exercise in animals and human: a scoping review

et al. 2022

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Objective This scoping review aimed to map evidence on açai supplementation combined with exercise in animal and/or human experimental studies. Methods The search considered six electronic databases and screening of relevant references. The selection process and data extraction were performed by two independent authors. The study characteristics, and AS (e.g., form, intervention time, amount ingested) and exercise (e.g., types, intensity, and duration) strategies were summarized, as well as their reported results. Results From an initial total of 342 studies identified; 11 (5 with animal and 6 with human models) were eligible. In animals, açai supplementation and exercise led to benefits in exercise tolerance and improvements in several hemodynamic parameters, as well as significant improvements in liver markers and glucose metabolism. In humans, açai supplementation indicated positive results in increasing exhaustion time to 90% of VO2max and increasing intensity at the anaerobic threshold. Conclusion We conclude that future research involving animals and humans should examine açai supplementation and exercise with (a) obesity models to test the effect of adiponectin on body composition with analysis of histological and histochemical parameters; (b) eccentric injury protocols with the incorporation of muscle quality variables to assess recovery; (c) chronic açai supplementation and strength training; (d) comparison of different forms of açai supplementation in exercise protocols.

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Biochemical assessment of oxidative stress by the use of açai (Euterpe oleracea Martius) gel in physically active individuals

Cited by 6 publications

References 15 publications

Euterpe oleracea fruit (Açai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection

Euterpe oleracea fruit (Açai)-enriched diet suppresses the development of experimental cerebral malaria induced by Plasmodium berghei (ANKA) infection

Efeitos da suplementação crônica de açaí sobre danos musculares em corredores de rua

Effect of açai supplementation (Euterpe Oleracea Mart.) associated with exercise in animals and human: a scoping review

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