Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis

Kamel, Hanan Hussein; Sarhan, Rania M.; Saad, Gamal R.

doi:10.1007/s12639-014-0431-9

Cited by 14 publications

(12 citation statements)

References 41 publications

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“…Lipid peroxidation was identified by increased seric and hepatic MDA levels of infected animals, which reflected the severity of cellular damage. Lipid peroxidation in cattle infected by F. hepatica enhanced the oxidation of polyunsaturated fatty acids and caused lipid peroxidation, as reported by Kamel et al (2015) in humans. The increase of MDA and ROS levels occurred at similar periods in this experiment.…”

Section: Discussionsupporting

confidence: 61%

“…Therefore, its suppression leads to H 2 O 2 accumulation up to toxic levels, as observed by Kamel et al . (2015) in hepatic tissue of patients with chronic fasciolosis. However, in this study increased hepatic GPx activity was observed in infected animals by F. hepatica, probably due to compensatory mechanisms for reduced CAT activity.…”

Section: Discussionmentioning

confidence: 99%

“…During the migration of juvenile forms of F. hepatica into the host liver, an intense inflammatory reaction is observed followed by fibrosis and cirrhosis, associated with chemical alterations in the cell, such as lipid peroxidation and changes in the antioxidant/oxidant status, which lead to an oxidative stress process mediated by ROS (Kolodziejczyk et al 2005; Bottari et al 2015). Recently, a study conducted by Kamel et al (2015) demonstrated that the antioxidant/oxidant status in liver tissue is altered in patients with chronic fasciolosis, and this contributes directly to the evolution of the disease, as well as the relationship between stage of disease and the activities of antioxidant enzymes, such as catalase (CAT) and superoxide dismutase (SOD).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected byFasciola hepatica

et al. 2017

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The aim of this study was to evaluate the oxidative stress in serum and liver and adenosine deaminase (ADA) activity of cattle experimentally infected by Fasciola hepatica. The group A consisted of five healthy animals (uninfected), and the group B was composed of five animals orally infected with 200 metacercariae of F. hepatica. On days 20, 40, 60 and 80 post-infection (PI) serum was collected to measure oxidative stress variables. On day 100 PI, animals were humanely euthanized and liver samples were collected. Infected animals showed lower (P < 0·05) seric ADA activities on days 40 and 60 PI but higher (P < 0·05) in the liver tissue compared with uninfected animals. Seric and hepatic reactive oxygen species (ROS) were higher (P < 0·05) in infected compared with uninfected animals. Hepatic thiobarbituric acid reactive substances were higher (P < 0·05) in infected animals. Catalase and glutathione S-transferase activities were lower in liver tissue of infected animals, while glutathione peroxidase was higher compared with uninfected (P < 0·05). In summary, we conclude that oxidative stress occurs in cattle experimentally infected by F. hepatica, mainly due to excessive ROS production in the course of fasciolosis, contributing to hepatic damage, and that increased in hepatic ADA activity may contribute to the inflammatory process.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected byFasciola hepatica

et al. 2017

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“…Most of the people chronically infected by Fasciola are asymptomatic but they are not necessarily free of inflammation [ 7 ]. There is a degree of inflammation into the liver in those chronically infected individuals by means of an increase in serum lipid peroxidation and a decrease in antioxidant enzymes, but the period between initial infection and developing of liver fibrosis in humans is still unknown [ 40 ]. Intensity of infection, length of infection, re-infections, other liver diseases, alcohol consumption, co-infection with chronic viral hepatitis, among others; are factors to be considered when assessing liver disease in infected individuals by Fasciola in endemic areas.…”

Section: Discussionmentioning

confidence: 99%

Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review

Machicado

Maco

et al. 2016

PLoS Negl Trop Dis

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BackgroundFascioliasis has been sporadically associated with chronic liver disease on previous studies. In order to describe the current evidence, we carried out a systematic review to assess the association between fascioliasis with liver fibrosis, cirrhosis and cancer.Methodology and Principal FindingsA systematic search of electronic databases (PubMed, LILACS, Scopus, Embase, Cochrane, and Scielo) was conducted from June to July 2015 and yielded 1,557 published studies. Among 21 studies that met inclusion and exclusion criteria, 12 studies explored the association of F. hepatica with liver fibrosis, 4 with liver cirrhosis, and 5 with cancer. Globally these studies suggested the ability of F. hepatica to promote liver fibrosis and cirrhosis. The role of F. hepatica in cancer is unknown. Given the heterogeneity of the studies, a meta-analysis could not be performed.ConclusionsFuture high-quality studies are needed to determine the role of F. hepatica on the development of liver fibrosis, liver cirrhosis, and cancer in humans.

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“…Many biologists reported that ALT and AST activities increased among patients who had acute Fasciola infection. 24 , 25 The higher value of ALT and AST is due to the stage of extensive destruction of the hepatic parenchyma which linked with some degree of hepatic necrosis that occurs during migration of immature worms. 26 Parenchymal damage in human fascioliasis occurs due to the activity of AST.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of human fascioliasis and its relationship with anti-Fasciola IgG and liver enzymes as biomarkers of pathogenicity

Afshan¹,

Kabeer²,

Firasat³

et al. 2020

Afr H. Sci.

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Background: Fascioliasis has never been considered a public health concern in Pakistan, although the increasing numbers of human cases reported in south Asia need a re-consideration in the country. The current study aimed to find the seroprevalence of human fascioliasis, associated risk factors and its relationship with liver enzymes as biomarkers of pathogenicity. Methods: The cross-sectional study was conducted in different districts of Punjab region from May 2014 to August 2016. A total of 546 respondents were screened by using enzyme-linked immunosorbent assay (ELISA) and serum biochemical tests. Results: Higher seroprevalence was recorded in Muzaffargarh (6.2%) and Bhara kahu (5.9%), while low infection rate in Gu- jranwala (1.1%) and Islamabad (1.5%). The results of multiple logistic regression analysis showed rural inhabitants (OR=7.9, 95%CI: 2.5-24.8), females (OR=3.5, 95%CI: 1.7-7.1), family size 3-7 (OR=1.7, 95%CI: 1.0-2.9) and socioeconomic condition (OR=3.9, 95%CI: 1.5-10.4) were the significantly (p<0.005) associated risk factors with disease. The results of liver enzymes i.e. aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase and cholesterol levels were significantly (p=0.001) elevated and associated with fascioliasis pathogenicity. Conclusion: The higher prevalence recorded may explain with Fasciola IgG antibodies for both active and past infections and cross reactivity of the assay with other helminthes. Keywords: Human fascioliasis; immunodiagnosis; liver enzymes; Pakistan.

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Biochemical assessment of oxidative status versus liver enzymes in patients with chronic fascioliasis

Cited by 14 publications

References 41 publications

Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected byFasciola hepatica

Oxidative stress and changes in adenosine deaminase activity of cattle experimentally infected byFasciola hepatica

Association of Fasciola hepatica Infection with Liver Fibrosis, Cirrhosis, and Cancer: A Systematic Review

Seroepidemiology of human fascioliasis and its relationship with anti-Fasciola IgG and liver enzymes as biomarkers of pathogenicity

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