Seroepidemiology of human fascioliasis and its relationship with anti-Fasciola IgG and liver enzymes as biomarkers of pathogenicity

Afshan, Kiran; Kabeer, Saman; Firasat, Sabika; Jahan, Sarwat; Qayyum, Mazhar

doi:10.4314/ahs.v20i1.26

Cited by 6 publications

(6 citation statements)

References 22 publications

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“…Fifteen different helminth species were represented, and these included Ancylostoma duodenale, Ascaris lumbricoides, Brugia malayi, Clonorchis sinensis, Fasciola hepatica, Necator americanus, Onchocerca volvulus, Opisthorchis viverinni, Schistosoma species (including S. haematobium, japonicum, and mansoni), Strongyloides stercoralifigs, Taenia solium, Trichuris trichiura, and Wuchereria bancrofti. Schistosoma species were most represented (S. mansoni (26), S. japonicum (8), unspecified Schistosoma species (7), and S. haematobium (2)) and studied in 43 studies, followed by mixed helminths (12), Strongyloides stercoralis (9), and others (20). The 34 records that did not meet Downs and Black criteria of "fair" or better quality are reported in S1 Supplemental Table . The associations of helminths with each of the 7 categories of cardiometabolic diseases and risk factors are discussed in the following sections.…”

Section: Resultsmentioning

confidence: 99%

“…Overall, studies investigating metabolic syndrome with non-schistosome helminth infections also reported similarly lower measures of metabolic syndrome-related parameters among infected individuals (n = 8) [16,17,47,58,59,63,65,69]. In contrast to the 22 total studies showing inverse associations between helminth infections and metabolic syndrome or parameters, 14 other studies showed no association [7,8,13,14,20,21,26,32,45,52,53,57,67,68]. These 14 studies included mostly human studies and investigated 4 Schistosoma, 4 mixed helminth, 3 Strongyloides, 1 Opisthorchis, 1 Fasciola, and 1 Ascaris infections.…”

Section: Helminths and Metabolic Syndromementioning

confidence: 97%

“…Including all helminths in other studies, 96% (24 of 25 total studies, which consisted of 11 human and 13 animal studies with 1 mixed study) that reported a relationship between helminth infection and lower total cholesterol found this inverse association to be significant [13,17,[24][25][26][27][28][29][30][31]33,35,[38][39][40][41]44,[46][47][48][49][50][51]54,55]. In contrast, 6 studies (14%, all with different helminths with 4 human and 2 animal studies) reported associations with increased total cholesterol [6,20,21,33,34,36], and 13 (30%, 10 human and 3 animal studies, of which 6 examined schistosome infections) demonstrated no effect of infection on total cholesterol [7,8,[14][15][16]22,23,32,36,37,42,43,53]. Notably, some studies reported differences in total cholesterol depending on factors such as duration of infection, co-morbidities, type of helminth infection, route of exposu...…”

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

“…Cross-sectional associations of helminth infections with metabolic syndrome. Thirtyeight studies examined the baseline associations between helminth infections on metabolic syndrome and related measures, of which 22 (58%; 12 animal, 9 human, 1 mixed human/animal) demonstrated lower metabolic syndrome and related measures [15][16][17]25,28,30,37,42,43,47,48,51,56,[58][59][60][61][62][63][64][65][66], 14 (37%; 13 human, 1 animal) showed no relationship [7,8,13,14,20,21,26,32,45,52,53,57,67,68], and 3 (8%; 2 human, 1 animal) reported an increase or variable changes in metabolic syndrome and related measures in association with helminth infections [6,66,69]. A large proportion of these studies (21/38) reported on blood levels of glucose or insulin; some also measured glucose intolerance or insulin resistance.…”

Section: Helminths and Metabolic Syndromementioning

confidence: 99%

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Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review

et al. 2023

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Background Globally, helminth infections and cardiometabolic diseases often overlap in populations and individuals. Neither the causal relationship between helminth infections and cardiometabolic diseases nor the effect of helminth eradication on cardiometabolic risk have been reviewed systematically in a large number of human and animal studies. Methods We conducted a systematic review assessing the reported effects of helminth infections and anthelmintic treatment on the development and/or severity of cardiometabolic diseases and risk factors. The search was limited to the most prevalent human helminths worldwide. This study followed PRISMA guidelines and was registered prospectively in PROSPERO (CRD42021228610). Searches were performed on December 10, 2020 and rerun on March 2, 2022 using Ovid MEDLINE ALL (1946 to March 2, 2022), Web of Science, Cochrane Library, Global Index Medicus, and Ovid Embase (1974 to March 2, 2022). Randomized clinical trials, cohort, cross-sectional, case-control, and animal studies were included. Two reviewers performed screening independently. Results Eighty-four animal and human studies were included in the final analysis. Most studies reported on lipids (45), metabolic syndrome (38), and diabetes (30), with fewer on blood pressure (18), atherosclerotic cardiovascular disease (11), high-sensitivity C-reactive protein (hsCRP, 5), and non-atherosclerotic cardiovascular disease (4). Fifteen different helminth infections were represented. On average, helminth-infected participants had less dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. Eleven studies examined anthelmintic treatment, of which 9 (82%) reported post-treatment increases in dyslipidemia, metabolic syndrome, and diabetes or glucose levels. Results from animal and human studies were generally consistent. No consistent effects of helminth infections on blood pressure, hsCRP, or cardiac function were reported except some trends towards association of schistosome infection with lower blood pressure. The vast majority of evidence linking helminth infections to lower cardiometabolic diseases was reported in those with schistosome infections. Conclusions Helminth infections may offer protection against dyslipidemia, metabolic syndrome, diabetes, and atherosclerotic cardiovascular disease. This protection may lessen after anthelmintic treatment. Our findings highlight the need for mechanistic trials to determine the pathways linking helminth infections with cardiometabolic diseases. Such studies could have implications for helminth eradication campaigns and could generate new strategies to address the global challenge of cardiometabolic diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Helminths and Metabolic Syndromementioning

confidence: 97%

Section: Plos Neglected Tropical Diseasesmentioning

confidence: 99%

Section: Helminths and Metabolic Syndromementioning

confidence: 99%

See 2 more Smart Citations

Effects of helminths and anthelmintic treatment on cardiometabolic diseases and risk factors: A systematic review

et al. 2023

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show abstract

“…There are more papers: chronic HIV infection and health related quality of life in resource poor settings 13 ; cryptococcosis among HIV patients in sub-Saharan Africa 14 ; malnutrition amongst HIV adult patients 15 ; viral suppression and low attrition in healthy HIV-infected patients initiated on ART with CD4 above 500 cells/µL 16 ; acceptance and utilization of HIV testing among the youth 17 ; rabies in Kwazulu-Natal 18 ; and central line-related bloodstream infections 19 . There are papers on Stenotrophomonas species 20 ; risk factors for trachoma in Burundi 21 ; plasmid-mediated resistance genes and multidrug-resistant uropathogens 22 ; prevalence of plasmodium , leptospira and rickettsia 23 ; seroepidemiology of human fascioliasis 24 ; Parvovirus B19 DNA detection in HIV anemic patients 25 ; safety of vaccines used in routine immunization in Africa 26 and distribution of genes among uropathogenic Escherichia coli and antimicrobial resistance 27 .…”

mentioning

confidence: 99%