Biochemical Alterations on Exposure of Imidacloprid and Curzate on Fresh Water Fish Oreochromis Mossambicus and Labeo Rohita

Desai, Bhavika; Parikh, Pragna

doi:10.5958/j.0973-9130.7.2.019

Cited by 12 publications

(11 citation statements)

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“…When exposed to high doses, loaches climbed, angled their bones, started to lose their balance before death. In fish, the major organ for the metabolic processes of components and energy is the liver, and its decontamination and phagocytosis have a survival advantage on living organisms (Desai & Parikh, 2013). Expose the fish to sublethal concentration of imidacloprid resulted in severe degenerative changes in the liver, and differences in the biochemical constituents in the gills, muscle and kidney as shown in Table 1.…”

Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

“…This finding means that imidacloprid caused hepatotoxicity and altered the cytomembrane permeability of hepatic cells resulting in loss ALT and AST into the bloodstream and consequently reduction in the activation of the liver aminotransferases (Xia et al, 2016). Besides, a significant alteration in ALT, AST, ALP and GDH was found in O. niloticus fish due to exposure to imidacloprid (Desai & Parikh, 2013). In addition, most insecticides cause behavioural and neurological disorders via inhibition of acetylcholinesterase (AChE) which leads to disturbances in feeding intake, swimming activity and the spatial orientation of the fish species (Banaee et al, 2008; Qadir et al, 2014).…”

Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

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The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Naiel

Shehata

Negm

et al. 2020

Reviews in Aquaculture

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Intensive fish culturing systems depend on provides optimal water quality conditions. Hence, the most important aquaculture practices are the removal of contamination elements related not only to the water quality parameters unacceptable for aquatic species but also to the undesirable effect on the health of fish and consumers. During the last three decades, common applications and production of pesticides have amplified progressively. Due to the excessive use of imidacloprid as a highly effective insecticide, elevated accumulation is expected in an aquatic environment. A large part of applied pesticides emitted into the environment and only a small portion of them reach the final biological target, where it caused several hazards, such as accumulation and toxicity to non‐target creatures. Plant‐derived secondary metabolites are getting great attention due to their safety and therapeutic functions. Also, several feed additives in animal diets can act as chemopreventive agents, which have the potential to decrease the toxicity risk of many pollutants and detoxification of activated metabolites. Understanding the internal action mechanisms of various safe feed additives could lead to the novel therapeutic approaches for acute and chronic pesticide toxicity. This review intends to summarize how safe feed additives alter or mitigate the toxic effects of imidacloprid in farmed fish.

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Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

Section: The Hazards and Acute Toxicity Of Imidacloprid In Cultured Fishmentioning

confidence: 99%

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Naiel

Shehata

Negm

et al. 2020

Reviews in Aquaculture

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“…As often happens with stressed fish, a massive infestation by a parasite, Trichodina ectoparasite , was observed in medaka fish in imidacloprid-treated fields (Sánchez-Bayo and Goka 2005 ). In a recent study, Desai and Parikh ( 2013 ) exposed freshwater teleosts, Oreochromis mossambicus and Labeo rohita , to sublethal concentration (LC 50/10 and LC 50/20 ) of imidacloprid for 21 days and found significant alterations in several biochemical parameters (ALT, AST, ALP, and GDH). Increased enzyme activity in tissues indicated liver damage, which the authors concluded, was linked to imidacloprid exposure.…”

Section: Fisheries and Aquaculturementioning

confidence: 99%

Risks of large-scale use of systemic insecticides to ecosystem functioning and services

Chagnon

Kreutzweiser

Mitchell

et al. 2014

Environ Sci Pollut Res

426

235

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Large-scale use of the persistent and potent neonicotinoid and fipronil insecticides has raised concerns about risks to ecosystem functions provided by a wide range of species and environments affected by these insecticides. The concept of ecosystem services is widely used in decision making in the context of valuing the service potentials, benefits, and use values that well-functioning ecosystems provide to humans and the biosphere and, as an endpoint (value to be protected), in ecological risk assessment of chemicals. Neonicotinoid insecticides are frequently detected in soil and water and are also found in air, as dust particles during sowing of crops and aerosols during spraying. These environmental media provide essential resources to support biodiversity, but are known to be threatened by long-term or repeated contamination by neonicotinoids and fipronil. We review the state of knowledge regarding the potential impacts of these insecticides on ecosystem functioning and services provided by terrestrial and aquatic ecosystems including soil and freshwater functions, fisheries, biological pest control, and pollination services. Empirical studies examining the specific impacts of neonicotinoids and fipronil to ecosystem services have focused largely on the negative impacts to beneficial insect species (honeybees) and the impact on pollination service of food crops. However, here we document broader evidence of the effects on ecosystem functions regulating soil and water quality, pest control, pollination, ecosystem resilience, and community diversity. In particular, microbes, invertebrates, and fish play critical roles as decomposers, pollinators, consumers, and predators, which collectively maintain healthy communities and ecosystem integrity. Several examples in this review demonstrate evidence of the negative impacts of systemic insecticides on decomposition, nutrient cycling, soil respiration, and invertebrate populations valued by humans. Invertebrates, particularly earthworms that are important for soil processes, wild and domestic insect pollinators which are important for plant and crop production, and several freshwater taxa which are involved in aquatic nutrient cycling, were all found to be highly susceptible to lethal and sublethal effects of neonicotinoids and/or fipronil at environmentally relevant concentrations. By contrast, most microbes and fish do not appear to be as sensitive under normal exposure scenarios, though the effects on fish may be important in certain realms such as combined fish-rice farming systems and through food chain effects. We highlight the economic and cultural concerns around agriculture and aquaculture production and the role these insecticides may have in threatening food security. Overall, we recommend improved sustainable agricultural practices that restrict systemic insecticide use to maintain and support several ecosystem services that humans fundamentally depend on.

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“…However, studies of the effects of IMD on rodents, chicken, fish, and bovids noted hepatotoxicity. Animals exposed to different doses of the insecticide exhibited signs and symptoms characteristic of liver damage, such as hemorrhage, hepatocyte degeneration, central venous congestion and dilatation, hepatic sinusoids (Kammon et al 2010;Mohany et al 2011;Toor, Sangha, and Khera 2013), pycnotic nuclei and leukocyte infiltration, as well as hypertrophied blood vessels, cytoplasmic lesions, and liver necrosis (Arfat et al 2014), with consequent release of enzymes aspartate aminotransferase and alanine aminotransferase in the extracellular medium (Arfat et al 2014;Desai and Parikh 2013;Duzguner and Erdogan 2012;Kapoor et al 2014;Mohany et al 2011;Qadir et al 2014;Soujanya et al 2013;Toor, Sangha, and Khera 2013).…”

Section: Discussionmentioning

confidence: 99%

“…A number of studies were conducted on the influence of IMD on animals including rats (Kapoor et al 2014;Mohany et al 2011;Toor, Sangha, and Khera 2013), mice (Arfat et al 2014), broiler chickens (Kammon et al 2010), fish (Desai and Parikh 2013;Qadir et al 2014), and bovids (Kaur, Sandhu, and Kaur 2006), demonstrating that the compound has the capacity to damage the liver. However, the mechanisms underlying the adverse actions in hepatic tissue remain to be determined.…”

Section: Introductionmentioning

confidence: 99%

Imidacloprid affects rat liver mitochondrial bioenergetics by inhibiting F_oF₁-ATP synthase activity

Bizerra

Guimarães

Maioli

et al. 2018

Journal of Toxicology and Environmental Health, Part A

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Imidacloprid (IMD) is a neonicotinoid insecticide widely used in crops, pets, and on farm animals for pest control. Several studies were conducted examining the adverse effects of IMD on animals often exhibiting hepatic damage. The aim of this study was to determine the effects of IMD on bioenergetics of mitochondria isolated from rat liver. Imidacloprid (50-200 µM) produced a concentration-dependent decrease in oxygen consumption and ATP production without markedly affecting mitochondrial membrane potential (MMP). Oxygen consumption experiments showed that IMD did not significantly affect the respiratory chain, and this was similar to findings with oligomycin and carboxyatractyloside, suggesting a direct action on FF-ATP synthase and/or the adenine nucleotide translocator (ANT). Imidacloprid inhibited FF-ATP synthase activity only in disrupted mitochondria and induced a partial inhibition of ADP-stimulated depolarization of the MMP. Our results indicate that IMD interacts specifically with FF-ATP synthase resulting in functional inhibition of the enzyme with consequent impairment of mitochondrial bioenergetics. These effects of IMD on mitochondrial bioenergetics may be related to adverse effects of this insecticide on the liver.

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Biochemical Alterations on Exposure of Imidacloprid and Curzate on Fresh Water Fish Oreochromis Mossambicus and Labeo Rohita

Cited by 12 publications

References 0 publications

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Risks of large-scale use of systemic insecticides to ecosystem functioning and services

Imidacloprid affects rat liver mitochondrial bioenergetics by inhibiting F_oF₁-ATP synthase activity

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Biochemical Alterations on Exposure of Imidacloprid and Curzate on Fresh Water Fish Oreochromis Mossambicus and Labeo Rohita

Cited by 12 publications

References 0 publications

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

The new aspects of using some safe feed additives on alleviated imidacloprid toxicity in farmed fish: a review

Risks of large-scale use of systemic insecticides to ecosystem functioning and services

Imidacloprid affects rat liver mitochondrial bioenergetics by inhibiting FoF1-ATP synthase activity

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Imidacloprid affects rat liver mitochondrial bioenergetics by inhibiting F_oF₁-ATP synthase activity