Biocatalytic synthesis of quinoline derivatives via α-amylase catalysed one-pot domino aza-Michael/Aldol/aromatization reactions

Construction of Bis‐Indole Derivatives Using α‐Amylase Enzyme: Application in the Gram‐Scale Synthesis of Bis‐Indole Containing Bioactive Molecules

“…[29,30] In this perspective, a number of new to nature reactions using amylase enzyme as a catalyst have been developed. [31] In 2015, Guan and co-workers developed a three component reaction for the synthesis of 3,3'-disubstituted oxindoles and spirooxindole pyrans using α-amylase from Hog pancreas. [32] Furthermore, a reaction between tryptamines, βketoesters and α,β-unsaturated aldehydes using α-amylase as a catalyst for the formation of highly substituted indoloquinolizines was established by Yu et al.…”

“…Interestingly, the use of enzymes such as heme‐proteins and hydrolases for catalysing new to nature organic reactions have seen exponential growth in the last few years [29,30] . In this perspective, a number of new to nature reactions using amylase enzyme as a catalyst have been developed [31] . In 2015, Guan and co‐workers developed a three component reaction for the synthesis of 3,3’‐disubstituted oxindoles and spirooxindole pyrans using α‐amylase from Hog pancreas [32] .…”

Production of a recyclable nanobiocatalyst to synthesize quinazolinone derivatives

“…20 These methods are able to provide DHQ efficiently, but have certain drawbacks, such as required high reaction temperature, longer reaction time, tedious workup, generation of toxic chemical waste, and use of a non-reusable catalyst. In continuation of our efforts in the area of biocatalysis, 21 herein, we have developed a reusable nanobiocatalyst via immobilization of lipase onto Fe 3 O 4 -decorated reduced graphene oxide to synthesize 2,3-dihydroquinazolinone-4(1 H )-ones using 2-aminobenzamide and aryl aldehydes ( Scheme 1e ).…”