Bioadhesive functional hydrogels: Controlled release of catechol species with antioxidant and antiinflammatory behavior

Puertas-Bartolomé, María; Benito-Garzón, Lorena; Fung, Stephanie; Kohn, Joachim; Vázquez‐Lasa, Blanca; Román, Julio San

doi:10.1016/j.msec.2019.110040

Cited by 60 publications

(38 citation statements)

References 102 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Incessant release of free radicals can activate the inflammatory system and impair the repair of the wound. [ 46 ] PEGSD2 had excellent antioxidant property, which could balance the oxidation/reduction pressure of wound site, thus regulating the inflammatory reaction. [ 1,46,47 ] Besides, catechol‐contained hydrogel might facilitate cell adhesion, attachment, and migration due to their good cell and extracellular matrix proteins affinity.…”

Section: Resultsmentioning

confidence: 99%

“…[ 46 ] PEGSD2 had excellent antioxidant property, which could balance the oxidation/reduction pressure of wound site, thus regulating the inflammatory reaction. [ 1,46,47 ] Besides, catechol‐contained hydrogel might facilitate cell adhesion, attachment, and migration due to their good cell and extracellular matrix proteins affinity. [ 35 ] In addition, gelatin component, as the collagen hydrolysate, can promote skin regeneration.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Zhao

Liang

Huang

et al. 2020

Adv Funct Materials

529

448

View full text Add to dashboard Cite

3+ coordination cross-linked poly(glycerol sebacate)-copoly(ethylene glycol)-g-catechol and quadruple hydrogen bonding crosslinked ureido-pyrimidinone modified gelatin. It possesses excellent anti-oxidation, NIR/pH responsiveness, and shape adaptation. Additionally, the hydrogel presents rapid self-healing, good tissue adhesion, degradability, photothermal antibacterial activity, and NIR irradiation and/or acidic solution washing-assisted removability. In vivo experiments prove that the hydrogels have good hemostasis of skin trauma and high killing ratio for methicillin-resistant staphylococcus aureus (MRSA) and achieve better wound closure and healing of skin incision than medical glue and surgical suture. In particular, they can significantly promote full-thickness skin defect wound healing by regulating inflammation, accelerating collagen deposition, promoting granulation tissue formation, and vascularization. These on-demand dissolvable and antioxidant physical double-network hydrogel adhesives are excellent multifunctional dressings for treating in vivo MRSA infection, wound closure, and wound healing.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Zhao

Liang

Huang

et al. 2020

Adv Funct Materials

529

448

View full text Add to dashboard Cite

show abstract

“…There are many pieces of literature reporting the antimicrobial activity of CH, and it also possesses hemostatic properties that enhance the blood clotting. 16 The enhanced antibacterial activity of the CHNPs is due to the nano size, spherical particles structure and high surface energy. They will get a large surface area to act on the cell wall of microorganisms.…”

Section: Antimicrobial Assessmentmentioning

confidence: 99%

“…14,15 It enhances the blood clotting by possessing hemostatic properties. 16 The structure of CH with the NH 3 + group adsorb on the cell wall of the microorganisms by the electrostatic interaction. It leads to damage of the cell wall integrity and leakage of macromolecules from bacteria.…”

Section: Introductionmentioning

confidence: 99%

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Bin-Jumah

Gilani

Jahangir³

et al. 2020

IJN

View full text Add to dashboard Cite

The topically administered drugs through conventional delivery systems have low bioavailability. Henceforth, the present study was designed to prepare and optimize clarithromycin (CTM)-loaded chitosan nanoparticles (CHNPs) to demonstrate the efficacy against microorganisms. Methods: Clarithromycin-loaded chitosan nanoparticles (CTM-CHNPs) were prepared by ionotropic gelation method. The formulation was optimized by box-Behnken design using the formulation variables like CH (A), STPP concentration (B), and stirring speed (C). Their effects were evaluated on the independent variables like particle size (Y 1) and entrapment efficiency (Y 2). Further, CTM-CHNPs were evaluated for physicochemical parameters, invitro drug release, ex-vivo permeation, bioadhesive study, corneal hydration, histopathology, HET-CAM, and antibacterial study. Results: The optimized formulation (CTM-CHNPopt) showed the low particle size (152±5 nm), which is desirable for ocular delivery. It also showed high encapsulation (70.05%), zeta potential (+35.2 mV), and was found in a spherical shape. The drug release study revealed a sustained drug release profile (82.98±3.5% in 12 hours) with Korsmeyer peppas kinetic (R 2 =0.996) release model. It showed a 2.7-fold higher corneal permeation than CTMsolution. CHNPs did not exhibit any sign of damage to excised goat cornea, which is confirmed by hydration, histopathology, and HET-CAM test. It exhibited significant (P<0.05) higher antibacterial susceptibility than CTM-solution. Conclusion: The finding of the study concluded that CTM-CHNPs can be used for effective management of bacterial conjunctivitis by increasing the precorneal residence time.

show abstract

“…Recently, the incessant release of free radicals has been proposed as one of the key factors responsible for activation of the inflammatory system, leading to impaired repair of the wound [4]. Therefore, the effective control of free radical levels in the wound and subsequent inflammation could assist in enhanced wound healing and scar control.…”

Section: Introductionmentioning

confidence: 99%

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

et al. 2019

View full text Add to dashboard Cite

A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel's hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system's bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6]. The antioxidant, anti-inflammatory, and anti-bacterial properties of this pleiotropic molecule need to be more utilized [7,8]. Although curcumin is a very promising molecule to be included in wound dressings, its hydrophobicity, extensive metabolism, and limited skin penetration often hamper its wider use [9]. We have recently proven that curcumin, a multitargeting active substance, exhibits superior anti-inflammatory properties when incorporated in tailored deformable liposomes [10]. In this work, we went a step further in the development of curcumin-based wound dressings and combined the beneficial properties of curcumin as an active moiety and chitosan hydrogel as a superior vehicle to form a bioactive wound dressing targeting the treatment of chronic wounds.An ideal dressing should assure an enhanced therapeutic outcome and reduction of pain accompanied with wound dressing changes [11]. Among the possible material to be used in the manufacturing of bioactive dressings, natural polymer-based wound dressings, such as hydrogels, represent promising advanced delivery systems with a low risk of toxicity and side effects due to their biodegradability and biocompatibility [12,13]. Hydrogels mimic the biochemical, biomechanical, and structural features of the extracellular matrix (ECM), serving as superior matrices for wound treatment [13,14]. Hydrogels additionally possess good bioadhesiveness that can contribute to a prolonged retention...

show abstract

Bioadhesive functional hydrogels: Controlled release of catechol species with antioxidant and antiinflammatory behavior

Cited by 60 publications

References 102 publications

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

Physical Double‐Network Hydrogel Adhesives with Rapid Shape Adaptability, Fast Self‐Healing, Antioxidant and NIR/pH Stimulus‐Responsiveness for Multidrug‐Resistant Bacterial Infection and Removable Wound Dressing

<p>Clarithromycin-Loaded Ocular Chitosan Nanoparticle: Formulation, Optimization, Characterization, Ocular Irritation, and Antimicrobial Activity</p>

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Contact Info

Product

Resources

About