Bioactive specialised metabolites from the endophytic fungus Xylaria sp. of Cudrania tricuspidata

Song, Jintong; Xu, Ke; Liu, Chunyu; Luan, Xiaoyi; Zhu, Lihua; Chu, Zhao-Jun; Fu, Xiaojie; Chang, Wenqiang; Wang, Xiaoning; Lou, Hongxiang

doi:10.1016/j.phytochem.2021.113079

Cited by 6 publications

(3 citation statements)

References 23 publications

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“…Among them, avonoids and xanthones are the representative constituents of Cudrania. At present, 82 kinds of avonoids, 97 kinds of xanthones, 20 kinds of organic acids, 6 kinds of polysaccharides and 21 kinds of phenylpropanoids have been isolated and identi ed in Cudrania, in addition, Cudrania also contains alkaloids, amino acids, steroids and glycosides [35]. The stems of Cudrania mainly contain triterpenoids and avonoids.…”

Section: Discussionmentioning

confidence: 99%

Non-targeted metabolomics and transcriptomics reveal mechanisms of metabolic differences among roots, stems, and leaves of Cudrania tricuspidata caryophyllata

Ding,

Zhao,

et al. 2023

Preprint

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Background Cudrania tricuspidata is a traditional Chinese medicinal herb with a long history of application, and has a variety of active ingredients and pharmacological effects. In order to expand the source of new drugs, we analysed the metabolomic and transcriptomic profiles of different tissues of Cudrania. The genetic basis for the accumulation of active ingredients was analysed, providing a theoretical basis for high-quality cultivation of Cudrania. Results We detected a total of 1254 metabolites from the three tissues of Cudrania roots, stems, and leaves, and all metabolites were annotated and classified into eight categories by the KEGG database: steroids, lipids, antibiotics, vitamins and cofactors, nucleic acids, peptides, carbohydrates, and organic acids. Flavonoid-rich roots and stems of Cudrania were significantly different from the transcripts of leaves. GO and KEGG enrichment analyses revealed that the differential genes were mainly enriched in Photosynthesis - antenna proteins, Zeatin biosynthesis, Flavone and flavonol biosynthesis, Monoterpenoid biosynthesis pathway. The expression of flavonoid and flavonol biosynthesis-related genes was significantly up-regulated in roots and stems. From the perspective of the differences in metabolites among roots, stems and leaves of Cudrania, it can provide a basis for revealing the material basis of the differences in medicinal properties and efficacy of different parts. Conclusion These results indicate that Cudrania is a promising medicinal plant and provide important information for the identification of differential metabolites and major metabolic pathways among different parts of Cudrania, as well as a theoretical reference for the effective use of Cudrania resources.

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Section: Discussionmentioning

confidence: 99%

Non-targeted metabolomics and transcriptomics reveal mechanisms of metabolic differences among roots, stems, and leaves of Cudrania tricuspidata caryophyllata

Ding,

Zhao,

et al. 2023

Preprint

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“…Five new 2,5-diarylcyclopentenones, including xylariaones A1-B2 ( 252 – 255 ) and xylaripyone H ( 256 ), were isolated from the Cudrania tricuspidata -derived fungus Xylaria sp. [ 88 ]. One new azaphilone derivative, xylariphilone ( 257 ), was isolated from the seagrass Halophila ovalis -derived fungus Xylaria sp.…”

Section: Structural and Biological Activity Studiesmentioning

confidence: 99%

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Chen,

Yu,

Chen

et al. 2024

JoF

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The fungus genus Xylaria is an important source of drug discoveries in scientific fields and in the pharmaceutical industry due to its potential to produce a variety of structured novel and bioactive secondary metabolites. This review prioritizes the structures of the secondary metabolites of Xylaria spp. from 1994 to January 2024 and their relevant biological activities. A total of 445 new compounds, including terpenoids, nitrogen-containing compounds, polyketides, lactones, and other classes, are presented in this review. Remarkably, among these compounds, 177 compounds show various biological activities, including cytotoxic, antimicrobial, anti-inflammatory, antifungal, immunosuppressive, and enzyme-inhibitory activities. This paper will guide further investigations into the structures of novel and potent active natural products derived from Xylaria and their potential contributions to the future development of new natural drug products in the agricultural and medicinal fields.

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“…At the same time, members of this genus are also commonly found in endophytes of vascular plants, so there are many types and contents of cytochalasin in this genus [ 7 , 8 ]. In addition, the type of bioactive compounds in the genus Xylaria also include polyketones [ 9 ], alkaloids [ 10 ], diphenyl ethers [ 11 ], diketopiperazines [ 12 ], triterpenoid glycosides [ 13 ], alkyl aromatics [ 14 ], and cyclic depsipeptides [ 15 ], with cytotoxic [ 16 ] and antithrombotic activity, acetylcholinesterase (AChE) inhibition, antibacterial activity, and phytotoxic activities [ 17 ]. In our previous study on Xylaria curta , a series of cytochalasins including Curtachalasins A–P were characterized [ 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity

et al. 2023

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Six previously undescribed cytochalasins, Curtachalasins X1–X6 (1–6), together with six known compounds (7–12) were isolated from the endophytic fungus Xylaria curta E10 harbored in the plant Solanum tuberosum. The structures were elucidated by the interpretation of HRESIMS, UV, and NMR data. The absolute configurations of Curtachalasins X1–X6 were determined by comparison of their experimental and calculated electronic circular dichroism (ECD) spectra. In bioassays, Curtachalasin X1 (1) and X5 (5) showed cytotoxic activity against the MCF-7 cell line with IC50 values of 2.03 μM and 0.85 μM, respectively.

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Bioactive specialised metabolites from the endophytic fungus Xylaria sp. of Cudrania tricuspidata

Cited by 6 publications

References 23 publications

Non-targeted metabolomics and transcriptomics reveal mechanisms of metabolic differences among roots, stems, and leaves of Cudrania tricuspidata caryophyllata

Non-targeted metabolomics and transcriptomics reveal mechanisms of metabolic differences among roots, stems, and leaves of Cudrania tricuspidata caryophyllata

Structures and Biological Activities of Secondary Metabolites from Xylaria spp.

Six Unprecedented Cytochalasin Derivatives from the Potato Endophytic Fungus Xylaria curta E10 and Their Cytotoxicity

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