Bioactive silk fibroin scaffold with nanoarchitecture for wound healing

Wang, Qiusheng; Zhou, Shuiqing; Wang, Lu; You, Renchuan; Yan, Shuqin; Zhang, Qiang; Li, Mingzhong

doi:10.1016/j.compositesb.2021.109165

Cited by 64 publications

(30 citation statements)

References 45 publications

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“…Eventually, considering the hydrophilicity and the drug-release properties of the membranes presented here, another medical field of application can be considered, which is the development of wound healing and wound dressing. Indeed, in addition to the importance of the antibacterial properties of these membranes, their hydrophilicity can be exploited for the wound exudate absorption; , moreover, the surface charges of the hydrophilic membranes could be used for their functionalization with bioactive compounds to improve and fasten wound healing.…”

Section: Discussionmentioning

confidence: 99%

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

Gruppuso

Guagnini

Musciacchio

et al. 2022

ACS Appl. Mater. Interfaces

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The employment of coaxial fibers for guided tissue regeneration can be extremely advantageous since they allow the functionalization with bioactive compounds to be preserved and released with a long-term efficacy. Antibacterial coaxial membranes based on poly-ε-caprolactone (PCL) and rifampicin (Rif) were synthesized here, by analyzing the effects of loading the drug within the core or on the shell layer with respect to non-coaxial matrices. The membranes were, therefore, characterized for their surface properties in addition to analyzing drug release, antibacterial efficacy, and biocompatibility. The results showed that the lower drug surface density in coaxial fibers hinders the interaction with serum proteins, resulting in a hydrophobic behavior compared to non-coaxial mats. The air-plasma treatment increased their hydrophilicity, although it induced rifampicin degradation. Moreover, the substantially lower release of coaxial fibers influenced the antibacterial efficacy, tested against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Indeed, the coaxial matrices were inhibitory and bactericidal only against S. aureus, while the higher release from non-coaxial mats rendered them active even against E. coli. The biocompatibility of the released rifampicin was assessed too on murine fibroblasts, revealing no cytotoxic effects. Hence, the presented coaxial system should be further optimized to tune the drug release according to the antibacterial effectiveness.

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Section: Discussionmentioning

confidence: 99%

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

Gruppuso

Guagnini

Musciacchio

et al. 2022

ACS Appl. Mater. Interfaces

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“…Skin wound repair is a dynamic and interactive process, including four different stages of hemostasis, inflammation, proliferation and tissue remodeling. [45][46][47] In order to explore the specific mechanism of the GL hydrogel for promoting wound healing, we extracted protein and RNA from the skin tissues on the 3rd, 7th, and 9th days after injury for the western blotting assay (Fig. 4D and E) and the real-time fluorescence qPCR experiments (Fig.…”

Section: Biomaterials Science Papermentioning

confidence: 99%

Construction of a sustained-release hydrogel using gallic acid and lysozyme with antimicrobial properties for wound treatment

et al. 2022

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“…It is crucial to choose the appropriate materials for ensuring the effectively functions of hydrogels. Among the naturally polymers for biological applications, silk protein, and sodium alginate are widely explored for regenerative medicine due to biocompatibility, biodegradation, and non-toxicity to the human body [ 8 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Eco-Friendly Bio-Hydrogels Based on Antheraea Pernyi Silk Gland Protein for Cell and Drug Delivery

Wang

Cheng

et al. 2022

Gels

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The Antheraea Pernyi silk gland protein originates from natural organisms and synthesized by tussah silk glands and has widely potential biomaterial applications due to the superior biocompatibility. This study investigates the Antheraea Pernyi silk gland protein-based drug-loaded bio-hydrogels for bioengineered tissue fabricated by using an eco-friendly method without the harsh extracting process and the usage of toxic chemicals. The drug-loaded bio-hydrogels exhibited a porous structure and interconnected pore walls. The swelling ratio and water absorption of drug-loaded bio-hydrogels were, respectively, above 95% and 1.5 × 103%. The cumulative release of drug loaded hydrogels all reached more than 90% within 4 h, and this indicates the potential of drug-loaded hydrogels as future drug-carrying biomaterials. RSC96 Schwann cells cultured on drug-loaded hydrogels for 72 h under cell culture medium show no toxic effects and more pro-proliferative effects. The results suggest the suitability of drug-loaded bio-hydrogels as natural biopolymer for the potential in vitro RSC96 cell culture platform and other biomaterial applications.

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Bioactive silk fibroin scaffold with nanoarchitecture for wound healing

Cited by 64 publications

References 45 publications

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

Tuning the Drug Release from Antibacterial Polycaprolactone/Rifampicin-Based Core–Shell Electrospun Membranes: A Proof of Concept

Construction of a sustained-release hydrogel using gallic acid and lysozyme with antimicrobial properties for wound treatment

Eco-Friendly Bio-Hydrogels Based on Antheraea Pernyi Silk Gland Protein for Cell and Drug Delivery

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