Eco-Friendly Bio-Hydrogels Based on Antheraea Pernyi Silk Gland Protein for Cell and Drug Delivery

Li, Jia; Wang, Boxiang; Cheng, Dehong; Lü, Yanhua

doi:10.3390/gels8070398

Cited by 3 publications

(2 citation statements)

References 33 publications

(32 reference statements)

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“…and free hydroxyl (−OH), along with ASGP, SA and PNIPAM, respectively [42,43]. According to the results of the FT-IR spectrum, the second derivative spectra and SEM, it is concluded that the abundant hydrogen bonds were formed between ASGP and SA, or ASGP and PNIPAM by the in situ polymerization method.…”

Section: Temperature Sensitivitymentioning

confidence: 97%

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

Li,

Guo,

Wang

et al. 2023

Gels

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The hard-healing chronic wounds of diabetics are still one of the most intractable problems in clinical skin injury repair. Wound microenvironments directly affect wound healing speed, but conventional dressings exhibit limited efficacy in regulating the wound microenvironment and facilitating healing. To address this serious issue, we designed a thermo-sensitive drug-controlled hydrogel with wound self-adjusting effects, consisting of a sodium alginate (SA), Antheraeapernyi silk gland protein (ASGP) and poly(N-isopropylacrylamide) (PNIPAM) for a self-adjusting microenvironment, resulting in an intelligent releasing drug which promotes skin regeneration. PNIPAM has a benign temperature-sensitive effect. The contraction, drugs and water molecules expulsion of hydrogel were generated upon surpassing lower critical solution temperatures, which made the hydrogel system have smart drug release properties. The addition of ASGP further improves the biocompatibility and endows the thermo-sensitive drug-controlled hydrogel with adhesion. Additionally, in vitro assays demonstrate that the thermo-sensitive drug-controlled hydrogels have good biocompatibility, including the ability to promote the adhesion and proliferation of human skin fibroblast cells. This work proposes an approach for smart drug-controlled hydrogels with a thermo response to promote wound healing by self-adjusting the wound microenvironment.

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Section: Temperature Sensitivitymentioning

confidence: 97%

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

Li,

Guo,

Wang

et al. 2023

Gels

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“…It is significant research value and application prospect that taking the fifth instar larvae of antheraea pernyi as the research object. In a previous study [26], we have investigated the possibility of Antheraea Pernyi silk gland protein/sodium alginate drug-loaded hydrogels with cell and drug delivery by composite coagulation bath including citric acid solution and CaCl 2 solution. In above paper, the bacteriostatic activity of bio-hydrogels was not investigated.…”

Section: Introductionmentioning

confidence: 99%

An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems

Wang

Cheng

et al. 2022

Gels

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To improve the versatility of the sodium alginate-loaded bio-hydrogels, Antheraea pernyi silk gland protein/sodium alginate drug-loaded hydrogels were prepared by using an eco-friendly multiple network cross-link technology. Fourier transform infrared (FT-IR) spectroscopy and UV-Vis spectrophotometer were used separately to evaluate the chemical structure and drug release behavior of drug-loaded hydrogels. The antibacterial drug carrier gels were evaluated by using inhibition zone test against the S. aureus and E. coli. The CCK-8 assay was used to assess the biocompatibility of drug loaded hydrogels. The FT-IR results showed that there was a strong interaction within the drug loaded hydrogels, and the ASGP was beneficial to enhance the interaction within the drug loaded hydrogels. UV-Vis spectrophotometer results indicated the cumulative release reached 80% within 400 min. Antibacterial bio-hydrogels had a good antibacterial property, especially the antibacterial bio-hydrogels with bacitracin exhibits superior to other antibacterial agents. The drug-loaded bio-hydrogels exhibited the adhesion and proliferation of RSC96 cells and perfected biocompatibility. This provides a new idea for further research and development of tissue-friendly drug-loaded biomaterials.

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Nonmulberry silk fibroin-based biomaterials: Impact on cell behavior regulation and tissue regeneration

et al. 2022

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Eco-Friendly Bio-Hydrogels Based on Antheraea Pernyi Silk Gland Protein for Cell and Drug Delivery

Cited by 3 publications

References 33 publications

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

Wound Microenvironment Self-Adjusting Hydrogels with Thermo-Sensitivity for Promoting Diabetic Wound Healing

An Eco-Friendly Antheraea Pernyi Silk Gland Protein/Sodium Alginate Multiple Network Hydrogel as Potential Drug Release Systems

Nonmulberry silk fibroin-based biomaterials: Impact on cell behavior regulation and tissue regeneration

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