Construction of a sustained-release hydrogel using gallic acid and lysozyme with antimicrobial properties for wound treatment

Abstract

The purpose of this study is to provide a new strategy to construct a temperature-controlled hydrogel using natural products through physical co-assembly as a promising agent for wound healing. Herein,...

Gallic acid: design of a pyrogallol-containing hydrogel and its biomedical applications

“…GA can directly crosslink with proteins, polysaccharides, and synthetic polymers to form hydrogels, 54,119,120 but there is possibly a lack of a deep understanding of the variables and mechanisms affecting supramolecular assembly. Moreover, due to the strong interaction tendencies of supramolecules within hydrogels, these hydrogels tend to form localized aggregates rather than uniform bulk structures.…”

“…126 In addition to interacting with proteins, GA can also induce protein self-assembly. Gong et al synthesized a hydrogel with GA and lysozyme, 119 which exhibited temperature sensitivity, self-healing ability, injectability, and antibacterial and antiinflammatory properties. The gelation mechanism might involve the polyphenol-induced misfolding of lysozyme, leading to the self-assembly of amyloidogenic lysozyme fibers.…”

“…This allows wounds to transition more quickly from the inflammatory phase to the proliferative phase. 100,119,190 High internal ROS production is typically induced in individuals with diabetes, leading to oxidative stress and apoptosis and ultimately causing damage to tissues such as the heart and kidneys. 191 Tran et al's experimental data have proven that in a high-glucose environment, GA-grafted CS hydrogels can clear the intracellular ROS, protect cells and maintain high cell activity (Fig.…”

“…For instance, a GA hydrogel prepared by Gong et al inhibited the growth of Escherichia coli and Staphylococcus aureus by almost 100% at a concentration of 12 mg mL −1 . 119…”

Photostimulated Extended Nitric Oxide (NO) Release from Water-Soluble Block Copolymer to Enhance Antibacterial Activity

“…Staphylococcus aureus is one such bacteria that is the leading cause of a plethora of clinical diseases, including endocarditis, osteomyelitis, pleuropulmonary, and soft tissue infections . Therefore, finding alternative strategies to prevent such health threats is relevant. , …”