Bioactive polymeric–ceramic hybrid 3D scaffold for application in bone tissue regeneration

Torres, Ana Luísa; Gaspar, Vítor M.; Serra, I R; Diogo, Gabriela S.; Fradique, Ricardo; Silva, Abílio P.; Correia, Ilídio J.

doi:10.1016/j.msec.2013.07.003

Cited by 71 publications

(76 citation statements)

References 67 publications

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“…Considering that chitosan is present in the composition of all scaffolds, the results obtained are in agreement with each other. Moreover, calcium and phosphate are also present, which was expected, due to the composition of β-TCP [35,49]. The CH/β-TCP scaffolds presents the higher content of these two ions.…”

Section: Energy Dispersive Spectroscopy Analysismentioning

confidence: 75%

“…In order to study the mechanical behavior of the scaffolds, uniaxial compression assays were performed through an adaptation of the method previously used by Torres and collaborators [35]. The compression assays were performed with a crosshead speed of 0.2 mm min −1 and a load cell of 5 kN, using a Zwick® 1435 Material Prüfung (Ulm, Germany).…”

Section: Evaluation Of the Mechanical Properties Of The Scaffoldsmentioning

confidence: 99%

“…The total porosity (P) of the different scaffolds was determined using a liquid displacement method [35]. Briefly, scaffolds with a known dry weight were placed in absolute ethanol (EtOH) for 48 h. EtOH was used due to its ability to permeate through the scaffolds without swelling or shrinking the matrix [37].…”

Section: Porosity Evaluationmentioning

confidence: 99%

“…Briefly, scaffolds with a known dry weight were placed in absolute ethanol (EtOH) for 48 h. EtOH was used due to its ability to permeate through the scaffolds without swelling or shrinking the matrix [37]. The total amount of EtOH that the scaffolds were able to absorb during 48 h was determined by applying the following equation [35]:…”

Section: Porosity Evaluationmentioning

confidence: 99%

“…Materials Science and Engineering C xxx (2015) xxx-xxx Presently, new composite systems combining advantages of polymers and ceramics arise as viable options to fulfill several demands needed for their application in bone tissue regeneration [25]. Several studies reported the osteoconductivity induced by HA [4,[26][27][28]. However, it has poor biodegradability, contrarily to β-TCP which presents a 10 times higher degradation rate [4,29].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Serra

Fradique

Vallejo

et al. 2015

Materials Science and Engineering: C

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137

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Section: Energy Dispersive Spectroscopy Analysismentioning

confidence: 75%

Section: Evaluation Of the Mechanical Properties Of The Scaffoldsmentioning

confidence: 99%

Section: Porosity Evaluationmentioning

confidence: 99%

Section: Porosity Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Serra

Fradique

Vallejo

et al. 2015

Materials Science and Engineering: C

Self Cite

137

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The effect of BMP‐2 and VEGF loading of gelatin‐pectin‐BCP scaffolds to enhance osteoblast proliferation

Amirian

Linh

Min

et al. 2014

J of Applied Polymer Sci

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A composite scaffold of gelatine (Gel)-pectin (Pec)-biphasic calcium phosphate (BCP) was successfully fabricated. Growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) were loaded into the Gel-Pec-BCP hydrogel scaffolds by freeze-drying. The surface morphology was investigated by scanning electron microscopy, and BCP dispersion in the hydrogel scaffolds was measured by energy dispersive and X-ray diffraction spectroscopy. The results obtained from Fourier transform infrared spectroscopy and quantitative measurements showed successfully loading of BMP-2 and VEGF into the Gel-Pec-BCP hydrogel scaffolds. In addition MC3T3-E1 preosteoblasts were cultivated on the three types of scaffolds to investigate the effects of BMP-2 and VEGF on cell viability and proliferation. The Gel-Pec-BCP scaffolds loaded with VEGF and BMP-2 demonstrated more cell spreading and proliferation compared to those of the Gel-Pec-BCP scaffolds.

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Definition of Pore Size in 3D‐Printed Porous Implants: A Review

et al. 2023

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3D-printed porous implants have been attracting increased attention. Although pore size is thought to be an important factor affecting the biocompatibility of implants, there is still no accurate conclusion about the optimal pore size of implants. In searching the relevant literature, it was found, that the pore size of implants is not clearly defined in many studies. Additionally, the definition methods are different in a few studies, that have clearly defined the apertures. In the current review, the definitions of pore size in different experiments are summarized and the factors affecting the definitions are analyzed, to provide an important framework for future research and design.

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Bioactive polymeric–ceramic hybrid 3D scaffold for application in bone tissue regeneration

Cited by 71 publications

References 67 publications

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

Production and characterization of chitosan/gelatin/β-TCP scaffolds for improved bone tissue regeneration

The effect of BMP‐2 and VEGF loading of gelatin‐pectin‐BCP scaffolds to enhance osteoblast proliferation

Definition of Pore Size in 3D‐Printed Porous Implants: A Review

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