Bioactive PCL matrices with a range of structural &amp; rheological properties

Douglas, Paula; Kuhs, Manuel; Sajjia, M.; Khraisheh, Majeda; Walker, Gavin; Collins, Maurice N.; Albadarin, Ahmad B.

doi:10.1016/j.reactfunctpolym.2016.02.004

Cited by 26 publications

(13 citation statements)

References 29 publications

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“…The tensile strength of Ch/HA membranes is attributed to the intermolecular hydrogen bonds between hydroxyl and amine groups in chitosan and the hyaluronan backbone and polyelectrolyte interaction between carboxylic and amine groups. Addition of MitoQ demonstrates a reduction in mechanical properties which may be attributed to a plasticization effect; a similar trend was shown in caprolactones upon additive addition [ 36 , 37 ] or the interruption of chain-chain intermolecular bonding. Overall, the mechanical measurements show that MitoQ molecules slightly disturb the membrane formation which occurs through polyelectrolyte ion-pair interactions as the resistance at break is slightly reduced.…”

Section: Resultsmentioning

confidence: 54%

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

et al. 2018

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Two self-associating biopolymers, namely chitosan (Ch) and a high-molar-mass hyaluronan (HA), were used to prepare membranes with the aim to protect and to enhance the healing of injured skin. A mitochondrially-targeted antioxidant—MitoQ—was incorporated into the mixture of biopolymers prior to their self-association. These three-component membranes were evaluated in detail utilising surface roughness measurements, contact angle measurements, hemocompatibility, and thrombogenicity analyses. Furthermore, in vivo application of Ch/HA/MitoQ membranes was assessed on injured rabbit and rat skin utilizing histological methods. The results showed that the prepared thrombogenic Ch/HA/MitoQ membranes had higher roughness, which allowed for greater surface area for tissue membrane interaction during the healing processes, and lower cytotoxicity levels than controls. MitoQ-loaded composite membranes displayed superior healing properties in these animal models compared to control membranes.

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Section: Resultsmentioning

confidence: 54%

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

et al. 2018

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“…A previous study by our group showed that combinations of HPMCP and Soluplus ® have a significant effect on the stability of spray dried ITZ against recrystallization (Davis et al, 2017). HME, a continuous and solvent-free processing method, employed for the preparation of ASDs has advanced as a trustworthy, scalable processing technology in the pharmaceutical industry (Douglas et al, 2016a;Douglas et al, 2016b;Radl et al, 2010). It has been used to prepare different dosage forms, such as; implants, tablets, process intermediates for controlled release and solubility enhancement of therapeutics (Keen et al, 2014;Lenz et al, 2017), with acceptable process scale-up and product quality control via process analytical technology (PAT).…”

Section: Introductionmentioning

confidence: 99%

Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus® processed by hot melt extrusion

Albadarin

Potter

Davis

et al. 2017

International Journal of Pharmaceutics

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The aim of this study was to evaluate a novel combination of hydroxypropyl methylcellulose phthalate (HPMCP-HP-50) and Soluplus polymers for enhanced physicochemical stability and solubility of the produced amorphous solid dispersions (ASDs). This was achieved using hot melt extrusion (HME) to convert the crystalline active pharmaceutical ingredient (API) into a more soluble amorphous form within the ternary systems. Itraconazole (ITZ), a Biopharmaceutics Classification System class II (BCS II) API, was selected as the model drug. The ASDs were characterized by Powder X-Ray diffraction (PXRD), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Fourier Transform Infrared (FTIR) spectroscopy, Solid State Nuclear Magnetic Resonance (ssNMR) and dissolution studies. The data showed that the ASDs were physically and chemically stable at 20°C and 50% RH over 12 months. PXRD results indicated that the ITZ in the ASDs was in the amorphous state and no recrystallization occurred. DSC scans confirmed that each formulation exhibited a single intermediate glass transition (T), around 96.4°C, indicating that ITZ was completely miscible in the polymeric blends of HPMCP and Soluplus at up to 30% (w/w) drug loading and that the two polymers were miscible with each other in the presence of ITZ. The FTIR analysis indicated the formation of strong hydrogen bonding between ITZ, HPMCP and Soluplus. The dissolution end-point of the ASDs was determined to be approximately 10 times greater than that of the crystalline ITZ.

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“…The elastic modulus ( Fig. 7 c) increased one order of magnitude with the particle content suggesting a stiffening effect of the polymer binder ( Douglas et al., 2016a ; Douglas et al., 2016b ; Guadagno et al., 2017 , Guadagno et al., 2014 ; Nohales et al., 2013 ). The elastic modulus varies in the following order vinylester >polyster>epoxy resins.…”

Section: Resultsmentioning

confidence: 96%

Thermosetting composites based on bronze particles for archaeological and artistic metal heritage cloning

Culebras

Herrero-Cortell

Gómez

et al. 2018

Heliyon

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Artificial Metals are polymeric semi-metallic composites obtained by combining thermosetting resins with atomized metal powders in order to achieve composite materials capable of reproducing metals, even in a rusty or corroded condition. These composites provide a solution for the reproduction of archaeological artefacts, sculptures, and ornaments for the purpose of conservation.This work explores mechanical properties of three different resins bronze composites loaded with two different proportions of metal filler. The degree of conversion of the samples was measured by differential scanning calorimetry (DSC) and flexural tests were carried out to determine their mechanical performance. In addition, the samples were characterized by scanning electron microscopy (SEM) in order to determine the morphology of the samples at the microscale.

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Bioactive PCL matrices with a range of structural & rheological properties

Cited by 26 publications

References 29 publications

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

Development of stability-enhanced ternary solid dispersions via combinations of HPMCP and Soluplus® processed by hot melt extrusion

Thermosetting composites based on bronze particles for archaeological and artistic metal heritage cloning

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