MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

Tamer, Tamer M.; Collins, Maurice N.; Valachová, Katarína; Hassan, Mohamed A.; Omer, Ahmed M.; Eldin, M.S. Mohy; Švík, Karol; Jurčík, Rastislav; Ondruška, Ľubomír; Bíró, Csaba; Albadarin, Ahmad B.; Šoltés, Ladislav

doi:10.3390/ma11040569

Cited by 83 publications

(29 citation statements)

References 34 publications

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“…The presence of deacetyl amine groups along polymer backbone provided its basic character and simplified its solubility in the acidic medium. The unique properties of chitosan such as non-toxicity, anti-bacterial activity, biodegradability and excellent biocompatibility 9 , 10 renders it widely used in the bio-medical applications as a drug carrier 11 , antimicrobial 12 , antioxidant 13 , antitumor 14 , and a wound dressing agent 15 , 16 . Therefore, chemical modifications of chitosan simplify its chemical transformation through the present NH 2 and OH − groups and allow the formation of several functional derivatives such as sulfonation 17 , amination 18 and carboxymethylation 19 .…”

Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Hassan

Omer

Abbas

et al. 2018

Sci Rep

174

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This study intends to develop novel two antimicrobial phenolic chitosan Schiff bases (I) and (II) via coupling of chitosan with Indole-3-carboxaldehyde and 4-dimethylaminobenzaldehyde, respectively, for boosting the antimicrobial activity of native chitosan. The alterations in the chemical structure and morphology of the Schiff bases were verified using FT-IR, electronic spectrum analysis, and SEM, whereas the thermal properties were investigated by TGA and DSC instruments. The results obtained from the potentiometric analysis referred that the degrees of substitution were 1.15 and 12.05% for Schiff bases (I) and (II), respectively. The antimicrobial activities of Schiff base (I) were significantly augmented more than Schiff base (II) and chitosan. Minimum inhibitory concentration (MIC) of Schiff base (I) was perceived at 50 µg/ml against tested microorganisms except for B. cereus and C. albicans. The highest concentration of Schiff base (I) could inhibit the growth of Gram-positive up to 99%. However, Schiff base (II) recorded the maximum inhibition rate versus Gram-positive approximately 82%. The cytotoxicity of the developed materials was estimated by MTT assay that substantiated their safety to fibroblast cells. The findings emphasized that the developed Schiff bases might be implemented as antimicrobial contenders to pure chitosan for treatments of wound infections.

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Section: Introductionmentioning

confidence: 99%

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Hassan

Omer

Abbas

et al. 2018

Sci Rep

174

View full text Add to dashboard Cite

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“…To create the rabbit ear wound, 5 white New Zealand rabbits (random distribution of male and female) were weighed and anesthetized with an intraperitoneal injection of phenobarbital sodium (150 mg/kg). Both ventral ears were treated with alcohol (75% volume) and draped aseptically [20,21]. One circular (5 mm in diameter) full-thickness wound was generated on the ventral vein side of each ear using a stainless-steel punch.…”

Section: Methodsmentioning

confidence: 99%

Metal Ion-Chelated Tannic Acid Coating for Hemostatic Dressing

et al. 2019

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Tannic acid (TA), a high-molecular-weight polyphenol, is used as a hemostasis spray and unguent for trauma wound remedy in traditional medical treatment. However, the use of tannic acid on a large-area wound would lead to absorption poisoning. In this work, a TA coating was assembled on a quartz/silicon slide, or medical gauze, via chelation interaction between TA and Fe3+ ions and for further use as a hemostasis dressing. Protein adsorption on the TA coating was further investigated by fluorescence signal, ellipsometry analysis and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The adsorbed bovine serum albumin (BSA), immunoglobulin G (IgG) and fibrinogen (Fgn) on the TA coating was in the manner of monolayer saturation adsorption, and fibrinogen showed the largest adsorption. Furthermore, we found the slight hemolysis of the TA coating caused by the lysed red blood cells and adsorption of protein, especially the clotting-related fibrinogen, resulted in excellent hemostasis performance of the TA coating in the blood clotting of an animal wound. Thus, this economic, environmentally friendly, flexible TA coating has potential in medical applications as a means of preparing novel hemostasis materials.

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“…Altering manufacturing parameters makes it possible for stimulating natural tissues with tailored biological characteristics appropriate for the recovery of tissues. The advantages of CS are actually broadly described; among the major positive aspects of CS, one can mention the capability to modify properties such as the degradation rate by altering the degree of deacetylation and it's Mw [157][158][159][160][161][162][163][164][165][166][167][168]. Additive components are regularly incorporated into CS in an effort to enhance its printability, fidelity, or to fabricate new cell-laden matrices.…”

Section: Benefits Limitations and Future Prospectsmentioning

confidence: 99%

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

et al. 2020

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Chitosan (CS) has gained particular attention in biomedical applications due to its biocompatibility, antibacterial feature, and biodegradability. Hence, many studies have focused on the manufacturing of CS films, scaffolds, particulate, and inks via different production methods. Nowadays, with the possibility of the precise adjustment of porosity size and shape, fiber size, suitable interconnectivity of pores, and creation of patient-specific constructs, 3D printing has overcome the limitations of many traditional manufacturing methods. Therefore, the fabrication of 3D printed CS scaffolds can lead to promising advances in tissue engineering and regenerative medicine. A review of additive manufacturing types, CS-based printed constructs, their usages as biomaterials, advantages, and drawbacks can open doors to optimize CS-based constructions for biomedical applications. The latest technological issues and upcoming capabilities of 3D printing with CS-based biopolymers for different applications are also discussed. This review article will act as a roadmap aiming to investigate chitosan as a new feedstock concerning various 3D printing approaches which may be employed in biomedical fields. In fact, the combination of 3D printing and CS-based biopolymers is extremely appealing particularly with regard to certain clinical purposes. Complications of 3D printing coupled with the challenges associated with materials should be recognized to help make this method feasible for wider clinical requirements. This strategy is currently gaining substantial attention in terms of several industrial biomedical products. In this review, the key 3D printing approaches along with revealing historical background are initially presented, and ultimately, the applications of different 3D printing techniques for fabricating chitosan constructs will be discussed. The recognition of essential complications and technical problems related to numerous 3D printing techniques and CS-based biopolymer choices according to clinical requirements is crucial. A comprehensive investigation will be required to encounter those challenges and to completely understand the possibilities of 3D printing in the foreseeable future.

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MitoQ Loaded Chitosan-Hyaluronan Composite Membranes for Wound Healing

Cited by 83 publications

References 34 publications

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Preparation, physicochemical characterization and antimicrobial activities of novel two phenolic chitosan Schiff base derivatives

Metal Ion-Chelated Tannic Acid Coating for Hemostatic Dressing

Three-Dimensional Printing Constructs Based on the Chitosan for Tissue Regeneration: State of the Art, Developing Directions and Prospect Trends

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