Bioactive Natural Products of Marine Sponges from the Genus Hyrtios

Abstract

Marine sponges are known as a rich source for novel bioactive compounds with valuable pharmacological potential. One of the most predominant sponge genera is Hyrtios, reported to have various species such as Hyrtios erectus, Hyrtios reticulatus, Hyrtios gumminae, Hyrtios communis, and Hyrtios tubulatus and a number of undescribed species. Members of the genus Hyrtios are a rich source of natural products with diverse and valuable biological activities, represented by different chemical classes including alkaloids, sesterterpenes and sesquiterpenes. This review covers the literature until June 2016, providing a complete survey of all compounds isolated from the genus Hyrtios with their corresponding biological activities whenever applicable.

Total synthesis of kealiiquinone: the regio-controlled strategy for accessing its 1-methyl-4-arylbenzimidazolone core

“…As alternative, the usage of tin(II) chloride in ethanol yielded the nitro group reduction in 54%. Similarly the reaction with selenium dioxide of this 2-aminoarylaniline furnished the structurally related 4-arylbenzo-[c] [1,2,5]selenadiazol 32 in 75% of yield. Under the same rationale, the regioselective methylation took place by heating 32 at 130 C in dimethyl sulfate, giving rise to the 4-anisylbenzo[c][1,2,5]selenadiazolium 33 in excellent 98% of yield.…”

“…The route C started with the reaction between the 2-aminoaniline 24 and selenium dioxide, to produce the benzo[c] [1,2,5]selenadiazol 27 in excellent 93% of yield. In agreement with the Milata 19 reports, these derivatives are methylated by heating in dimethyl sulfate as solvent.…”

“…Data of known compounds were compared with existing literature characterization data and the references are given. 1 Sequence followed in Scheme 3 5,6-Dibromo-1,3-dihydro-2H-benzo [d]imidazol-2-one (3). 4,5dibromo phenylenediamine 2 (1.0 g, 3.80 mmol) was charged into a 100 mL two-necked round bottom ask and dissolved in 30 mL of toluene.…”

“…IR (neat, n/cm À1 ): 3376,3113,3032,2919,2850,2258,1687,1616,1586,1485,1440,1376,1307,1240,1178,1105,1074,959,879,826,736,718, 670. 1 6-Bromo-4-(4-methoxyphenyl)-1-methyl-1,3-dihydro-2H-benzo [d]imidazol-2-one (21). To a solution of 6-bromo-4-iodo-1methyl-1,3-dihydro-2H-benzo [d]imidazol-2-one 26 (2.5 g, 7.207 mmol) in 1,4-dioxane (60 mL) and water (5 mL) were added panisyl boronic acid (1.35 g, 8.649 mmol, 1.2 equiv.…”

Molecular Docking of Hyrtimomine a-K From Marine Sponge Hyrtios Spp. As Anticancer Target of Phosphoinositide-Dependent Kinase 1

“…Hyrtimomine F and G are bisindole alkaloid with the former having α-keto-ε-caprolactam structure [20]. Hyrtimomine H-K is four new alkaloids with beta-carboline skeleton [21]. The structures of all the hyrtimomines given in Table 1 were downloaded from PubChem database in SDF format.…”