Bioactive Hybrid Organogels Based on Miniemulsion Synthesis of Morphologically Complex Polymer/Surfactant/Calcium Phosphate Nanostructures

Abstract

Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis­(2-ethylhexyl)­phosphate (Ca­(DEHP)2) surfactant and poly­(ethylene oxide)19-poly­(propylene oxide)69-poly­(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

Synthesis of Calcium Phosphate Composite Organogels by Using Emulsion Method for Dentine Occlusion Materials

“…Moreover, the large particles, approximately 90-110 nm diameters, which presumably from agglomeration of the small particles by themselves were observed. Referred from previous paper [7], the results showed that SDS was the main component to form water-in-oil emulsions and nanofibrous structure, whereas the addition of P123 as template could still stabilize the spherical structure. However, nanofibrous structure might be changed to the thicker network nanofibers.…”

“…Emulsion methods are known to be low-cost procedures performing under mind condition and can be used to produce small particle sizes (in nanometer to submicron) [6]. Pluronic polymer, poly (ethylene oxide)19-block-Poly (propylene oxide)69-block-poly (ethylene oxide)19 (P123), has widely used as a template to form gel, and control the size, structure and morphology of particles [7]. In this study, P123 was added in order to form a gel which could facilitate the application of the product on the exposed teeth.…”

Structural insights in Dy3+‐doped β‐Tricalcium phosphate and its multimodal imaging characteristics

“…β‐Tricalcium phosphate [β‐TCP, β‐Ca 3 (PO 4 ) 2 ] as a bioactive material has found wide applications in biomedicine . β‐Ca 3 (PO 4 ) 2 offers advantage of accepting wide range of cationic substitutions in its five different in‐equivalent Ca 2+ sites .…”

A Three‐Dimensional Hierarchical Dandelion‐Like HMX Architecture Formed at a Liquid‐Liquid Interface

“…The hierarchical micro/nano-architecture constructed by nanobuilding blocks via bottom-up approaches has attracted special interest because of their unique physical and chemical properties and potential application in the fields of materials. [1][2][3][4] Presently, much attention has been devoted to develop various methods to prepare hierarchical micro/nano-architectures, including template-assisted growth, electrochemical deposition, and various solution techniques et al [5][6][7][8][9] Regretfully, these approaches mentioned above have been mostly applied to inorganic materials. Few efforts focus on the fabrication of hierarchical micro/nano-architectures of organic small molecule materials, especially energetic materials.…”