2002
DOI: 10.1590/s0102-695x2002000300036
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Bioactive derivatives obtained from lecanoric acid, a constituent of the lichen Parmotrema tinctorum (Nyl.) Hale (Parmeliaceae)

Abstract: With the aim of obtaining new compounds with potential antifungal activity, lecanoric acid, a chemical constituent of the lichen Parmotrema tinctorum and its derivatives prepared from structural modification were tested against the fungus Cladosporium sphaerospermum, by employing the bioautographic method. Activity of the derivatives ranged from 10- to 1-μg concentrations. Results demonstrated this series of compounds to have potent fungitoxic activity

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Cited by 17 publications
(4 citation statements)
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“…Lichen acids, atranorin, and lecanoric acid were detected in the TLC profile of P. tinctorum and the GC-MS analysis confirmed the presence of atraric acid, orcinol, and O-orsellinaldehyde among the major constituents. Previous studies have also detected O-orsellinaldehyde and orcinol as bioactive derivatives obtained from lecanoric acid [38][39][40]. Similar antimicrobial activities were reported by Gomes et al for the lecanoric acid isolated from the lichen, P. tinctorum [41].…”
Section: Discussionsupporting
confidence: 82%
“…Lichen acids, atranorin, and lecanoric acid were detected in the TLC profile of P. tinctorum and the GC-MS analysis confirmed the presence of atraric acid, orcinol, and O-orsellinaldehyde among the major constituents. Previous studies have also detected O-orsellinaldehyde and orcinol as bioactive derivatives obtained from lecanoric acid [38][39][40]. Similar antimicrobial activities were reported by Gomes et al for the lecanoric acid isolated from the lichen, P. tinctorum [41].…”
Section: Discussionsupporting
confidence: 82%
“…ex Nyl.) Hale., a radially growing foliose macrolichen, was used as a model lichen species for the following reasons: it is distributed widely in the tropical and subtropical regions of the world [ 17 , 18 ]; it is loosely attached to the substrate so that the thallus can be peeled off easily and cleanly from the substrate, e.g., bark and rock; mature thallus of P. tinctorum has sufficient biomass for the test. Five individual lichen thalli were collected from the bark of pine trees ( Pinus thunbergii Parl.)…”
Section: Methodsmentioning
confidence: 99%
“…The amounts of remaining identified metabolites were presented in the following order: atranorin > obtusic acid > ethyl haematommate > methyl-β orcinol carboxylate. Lecanoric acid have previously been reported from the lichen Parmotrema tinctorum and other lichens genus, but this is the first time to confirm the presence of this metabolite in the lichen Physcia semipinnata [7]. Methyl-β-orcinol carboxylate and ethyl haematommate are known to be an intermediate product in depside biosynthesis.…”
Section: Resultsmentioning
confidence: 68%