Bioactive compounds from Cornus officinalis fruits and their effects on diabetic nephropathy

Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathic activity [31][32][33][34], but this study has first reported the potential muscle protective effect of loganin. In SMA, despite the above-mentioned beneficial effects of loganin such as SMN restoration and neuroprotection, the potential muscle protection of loganin via regulating two major protein synthesis pathways, a positive regulator Akt/mTOR pathway and a negative regulator atrogin-1/MuRF-1 pathway were also revealed in this study.…”

“…Loganin has been mentioned for its glucose-lowering effect [27] and anti-diabetic nephropathy activity [31][32][33][34]; however, the protective effects and mechanisms of loganin on SMN-deficient neuron and atrophic muscle are firstly investigated here. In the present study, the effects of loganin on SMA were investigated in a severe SMA animal model, SMA7 mice and in two cellular models of SMA, SMN-deficient motor neuron-like NSC34 cells and skin fibroblasts from SMA patients.…”

Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

“…The iridoid and flavonoid fraction of C. mas is quite different to the C. officinalis traditionally used in Chinese medicine to increase urine flow and decrease blood pressure [36]. The main constituents of the iridoid fraction of C. mas fruits were loganic acid and morroniside, which are considered as biologically active compounds [37]. …”

“…The same authors identified loganin (methyl ester of loganic acid) as well as sweroside, although they did not perform quantitative analyses. Loganic acid belongs to a large natural-compound group of terpenes called iridoids, which has also been found in plants like Gentiana linearis [42] , Strychnos nux-vomica [40] or, recently, Cornus officinalis fruits [37, 43], but in much lower concentrations. The related C. mass species, C .…”

Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats

“…Cornus officinalis, a species of dogwood, has been used for thousands of years as an important folk medicine, and it is also considered as one of the 25 vegetable drugs that are most frequently applied in PR China, Japan and Republic of Korea (Cao et al, 2011;Han et al, 2014;Ma et al, 2014). Cornus officinalis exhibits a number of biological activities, including immunological regulation, reducing blood glucose, antishock, antiarrhythmia and antibiosis (Lee et al, 2011;Park et al, 2011).…”