Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats

Zhao, Min; Qian, Dawei; Shang, Erxin; Jiang, Shu; Guo, Jianming; Liu, Pei; Su, Shulan; Duan, Jin‐Ao; Du, Lijun; Jiang, Tao

doi:10.1016/j.jep.2015.07.037

Cited by 26 publications

(16 citation statements)

References 36 publications

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“…In our study, protocol of loganin pre‐treatment explains that when MPTP administration stopped, loganin treatment stopped as well. Previous assay reports that MPTP and its metabolite are still be detected 2 days after last MPTP injection [Yang et al, ], which means MPTP toxicity may still exist while loganin may decrease at a low concentration or is in exhaustion [Zhao et al, ]. This may lead to pre‐treatment of loganin failed to fight against the toxicity induced by the rest of MPTP.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Loganin on MPTP‐Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

Cui

Sun

et al. 2017

J of Cellular Biochemistry

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Parkinson's disease (PD) is a progressive neurodegenerative disease, involving resting tremor and bradykinesia, for which no recognized therapies or drugs are available to halt or slow progression. In recent years, natural botanic products have been considered relatively safe, with limited side effects, and are expected to become an important source for clinical mediation of PD in the future. Our study focuses on the ability of loganin, a compound derived from fruits of cornus, to mediate neuroprotection in a mouse model of PD. Mice were administered 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) with a dosage of 30 mg/kg daily for 5 days to establish a subacute PD model and treated with loganin. Locomotor activity was assessed by a pole test, then mice were euthanized at 1 and 3 days after the last treatment, and brain tissue was prepared for subsequent assays. Loganin rescued decrease of dopamine levels and tyrosine hydroxylase (TH) expression in the striatum, and shortened total locomotor activity (TLA) time of mice. Furthermore, loganin alleviated microglia and astrocyte activation, and suppressed TNF‐α and caspase‐3 expression through a c‐Abl‐p38‐NFκB pathway. Loganin also downregulated LC3‐II and Drp1 expression, and decreased the level of acidic vesicular organelles (AVOs). Loganin exerts neuroprotective effects on MPTP‐induced PD mice by decreasing inflammation, autophagy, and apoptosis, suggesting that loganin could serve as a therapeutic drug to ameliorate PD. J. Cell. Biochem. 118: 3495–3510, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%

Neuroprotective Effects of Loganin on MPTP‐Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

Cui

Sun

et al. 2017

J of Cellular Biochemistry

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“…So far, numerous works have proved the physiological and pathological effects on the absorption and elimination of non-polymorphic drugs. These influencing factors generally refer to age, diabetes, nephropathy and hepatopathy 6 , 7 , 8 , 9 . Considering the factor of age, possible reasons for these pharmacokinetic changes are diverse and complex.…”

Section: Introductionmentioning

confidence: 99%

Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration

Liu

Wang

Chen

et al. 2016

Acta Pharmaceutica Sinica B

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The previous investigation has proved that their existed pharmacokinetic difference between the different crystal forms of the polymorphic drugs after oral administration. However, no systemic investigations have been made on the change of this pharmacokinetic difference, resulted either from the physiological or from the pathological factors. In this paper, we used polymorphic nimodipine (Nim) as a model drug and investigated the effect of age difference (2- and 9-month old) on the pharmacokinetics after oral delivery in rats. As the results shown, for L-form of Nim (L-Nim), the AUC0–24 h in 2-month-old rats was 343.68±47.15 ng·h/mL, which is 23.36% higher than that in 9-month-old rats. For H-form of Nim (H-Nim), the AUC0–24 h in 2-month-old rats was 140.91±19.47 ng·h/mL, which is 54.64% higher than that in 9-month-old rats. The AUC0–24 h ratio between H-Nim and L-Nim was 2.44 in 2-month-old rats and 3.06 in 9-month-old rats. Since age difference could result in unparallelled change of the absorption and bioavailability of the polymorphic drugs, the results in this experiment are of value for further investigation of crystal form selection in clinical trials and rational clinical application of the polymorphic drugs.

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“…The peak area ratio ( y ) of the analyte to the IS vs. the nominal concentration ( x , ng/mL) was used to plot the calibration curve and determine the linearity with weighted (1/ x 2 ) least square linear regression [ 34 ]. LLOQ of the method was determined based on the signal to noise ratio of 10:1 with the acceptable precision in six replicates of blank plasma (RSD ≤ 20%) [ 35 ].…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetic Comparisons of Multiple Triterpenic Acids from Jujubae Fructus Extract Following Oral Delivery in Normal and Acute Liver Injury Rats

Guo

Quan-jin

et al. 2018

IJMS

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Jujubae Fructus, the dried fruit of Ziziphus jujuba, has been used as Chinese medicine and food for centuries. Triterpenic acids have been found to be the major bioactive constituents in Jujubae Fructus responsible for their hepatoprotective activity in previous phytochemical and biological studies, while few pharmacokinetic studies have been conducted. To reveal the kinetics of the triterpenic acids under the pathological liver injury state, an established ultra-performance liquid chromatography coupled with a mass spectrometry method was applied for the simultaneous quantitation of seven triterpenic acids (ceanothic acid, epiceanothic acid, pomonic acid, alphitolic acid, maslinic acid, betulinic acid, and betulonic acid) in plasma samples of normal and acute liver injury rats induced by CCl4. The results showed that there were significant differences (p < 0.05) in the pharmacokinetic parameters of seven triterpenic acids between model and normal groups. The AUC0–t and AUC0–∞ of epiceanothic acid (5227 ± 334 μg⋅h/L vs. 1478 ± 255 μg⋅h/L and 6127 ± 423 μg⋅h/L vs. 1482 ± 255 μg⋅h/L, respectively) and pomonic acid (4654 ± 349 μg⋅h/L vs. 1834 ± 225 μg⋅h/L and 4776 ± 322 μg⋅h/L vs. 1859 ± 230 μg⋅h/L, respectively) in model rats were significantly higher than those in normal rats, and the CLz/F of them were significantly decreased (0.28 ± 0.02 L/h/kg vs. 1.36 ± 0.18 L/h/kg and 19.96 ± 1.30 L/h/kg vs. 53.15 ± 5.60 L/h/kg, respectively). In contrast, the above parameters for alphitolic acid, betulinic acid and betulonic acid exhibited the quite different trend. This pharmacokinetic research might provide useful information for the clinical usage of triterpenic acids from Jujubae Fructus.

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Comparative pharmacokinetics of the main compounds of Shanzhuyu extract after oral administration in normal and chronic kidney disease rats

Cited by 26 publications

References 36 publications

Neuroprotective Effects of Loganin on MPTP‐Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

Neuroprotective Effects of Loganin on MPTP‐Induced Parkinson's Disease Mice: Neurochemistry, Glial Reaction and Autophagy Studies

Effect of age on the pharmacokinetics of polymorphic nimodipine in rats after oral administration

Pharmacokinetic Comparisons of Multiple Triterpenic Acids from Jujubae Fructus Extract Following Oral Delivery in Normal and Acute Liver Injury Rats

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