Application of Cornelian Cherry Iridoid-Polyphenolic Fraction and Loganic Acid to Reduce Intraocular Pressure

Abstract

One of the most common diseases of old age in modern societies is glaucoma. It is strongly connected with increased intraocular pressure (IOP) and could permanently damage vision in the affected eye. As there are only a limited number of chemical compounds that can decrease IOP as well as blood flow in eye vessels, the up-to-date investigation of new molecules is important. The chemical composition of the dried Cornelian cherry (Cornus mas L.) polar, iridoid-polyphenol-rich fraction was investigated. Loganic acid (50%) and pelargonidin-3-galactoside (7%) were found as the main components. Among the other constituents, iridoid compound cornuside and the anthocyans cyanidin 3-O-galactoside, cyanidin 3-O-robinobioside, and pelargonidin 3-O-robinobioside were quantified in the fraction. In an animal model (New Zealand rabbits), the influence of loganic acid and the polyphenolic fraction isolated from Cornelian cherry fruit was investigated. We found a strong IOP-hypotensive effect for a 0.7% solution of loganic acid, which could be compared with the widely ophthalmologically used timolol. About a 25% decrease in IOP was observed within the first 3 hours of use.

Functional properties of Cornelian cherry (Cornus mas L.): a comprehensive review

“…Results provided by Szumny et al show that Cornelian cherry extracts can help in intraocular pressure decrease, which is linked with a high concentration of iridoids, especially loganic acid, in extracts [80].…”

Cornus mas L. Stones: A Valuable by-Product as an Ellagitannin Source with High Antioxidant Potential

“…Their shape is oval or spherical, and they have an average length of 1.00–2.22 cm and weight of 0.39–3.78 g [ 4 , 5 ]. Fruits are attractive for direct consumption and production of jams, juices, alcoholic beverages, and pickles which have been proven to be a rich source of health-promoting compounds, such as polyphenols (anthocyanins, flavonols, and phenolic acids), iridoids, terpenoids (ursolic acid), and vitamin C [ 2 , 6 , 7 ]. This fact probably justifies the traditional applications of cornelian cherry [ 2 , 8 ].…”

Hypoglycaemic, antioxidative and phytochemical evaluation of Cornus mas varieties

“…For each tested parameter, statistical differences between samples were identified using ANOVA test (α = 0.05). The correlation between tested parameters was determined (6) %inhibition activity =…”

“…In prior studies, an effect of individual iridoids was assayed and strong anti-inflammatory properties of loganic acid were observed. Loganic acid (administered topically in a form of eye drops) decreased intraocular pressure, which may be used in glaucoma treatment [6]. Moreover, the compound administered with diet may have a beneficial effect on lipid metabolism, which was observed as changes in triglyceride levels and HDL cholesterol fractions [7].…”