Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function

Ducheyne, Paul; Qiu, Qingqing

doi:10.1016/s0142-9612(99)00181-7

Cited by 1,027 publications

(796 citation statements)

References 80 publications

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“…Synthetic HAp has been shown to be biocompatible and promotes osteoblast adhesion and migration/infiltration in vitro. 129 132,149 However, CaP materials are most successful as implant coatings considering their mechanical properties exclude them from being viable options in 3D scaffold applications. 150,151 Protein and Peptide Recognition.…”

Section: Chemical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

672

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Chemical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

672

499

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“…As a result, the reactivity of the templating constituent has a significant effect on the adherence and structuring of hydroxyapatite in any biological material [65].…”

Section: Biomineralsmentioning

confidence: 99%

Structure and mechanical properties of selected protective systems in marine organisms

Naleway

Taylor

Porter

et al. 2016

Materials Science and Engineering: C

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“…[31][32][33] Ceramics derived from calcium phosphate mimics the mineral structure of bone, and bone cells were shown to recognize and bind to such ceramics. 34,35 Calcium phosphate-based ceramics have been previously shown to display bone integration properties 36,37 and calcium aluminate further increases osteointegration. 38,39 Alumina ceramics, including porous alumina allows the attachment, growth and differentiation of bone cells, the materials grain microstructure being important for cell behavior, including for a human bone-derived cell line.…”

Section: Discussionmentioning

confidence: 99%

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

et al. 2012

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Bone substitute materials permissive for trans-scaffold migration and in-scaffold survival of human bone-derived cells are mandatory to develop cell-engineered permanent implants to repair bone defects. In this study, we evaluated the influence on human bone-derived cells of the material composition and microstructure of foam scaffolds made from calcium aluminate using a direct foaming method allowing wide-range tailoring of the microstructure for pore size and pore openings. Human fetal osteoblasts attached to the scaffolds, migrated across the entire materials depending on the scaffold pore size, colonized and survived in the porous material for at least 6 weeks. The long-term biocompatibility of the scaffold material for human cells was evidenced by in scaffold determination of cell metabolic activity using a modified MTT assay, a repeated WST-1 assay and scanning electron microscopy. Finally, we demonstrated that the fetal cells can be covalently bound to the scaffolds using biocompatible click chemistry, thus enhancing the rapid adhesion of the cells to the scaffolds. Thus, the different microstructures of the foams influenced the migratory potential of the cells, but not cell viability, and the scaffolds were permissive for covalent biocompatible chemical binding of the cells to the materials, allowing either localized or widespread cellularization of the scaffolds for cell-engineered implants.

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Bioactive ceramics: the effect of surface reactivity on bone formation and bone cell function

Cited by 1,027 publications

References 80 publications

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Structure and mechanical properties of selected protective systems in marine organisms

Functionalization of Microstructured Open-Porous Bioceramic Scaffolds with Human Fetal Bone Cells

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