Bioactive alkyl phenols and embelin from Oxalis erythrorhiza

Feresin, Gabriela Egly; Tapia, Alejandro; Sortino, Maximiliano; Zacchino, Susana; Árias, Antonieta Rojas de; Inchausti, Alba; Yaluff, Gloria; Rodrı́guez, Jaime A.; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo

doi:10.1016/s0378-8741(03)00258-7

Cited by 83 publications

(58 citation statements)

References 32 publications

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“…Embelin has previously been shown to have antitumor, anti-inflammatory and analgesic properties (42). Embelin has also been identified as a small molecular inhibitor of XIAP (43).…”

Section: Discussionmentioning

confidence: 99%

Embelin prevents LMP1-induced TRAIL resistance via inhibition of XIAP in nasopharyngeal carcinoma cells

Yang¹,

Li²,

Yang³

et al. 2016

Oncology Letters

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Abstract. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in the majority of tumor cells, whilst sparing normal cells. However, the potential use of TRAIL in the treatment of cancer is limited by the inevitable emergence of drug resistance. The present study reports the upregulation of latent membrane protein 1 (LMP1)-induced TRAIL resistance via the enhanced expression of X-linked inhibitor of apoptosis protein (XIAP) in nasopharyngeal carcinoma (NPC) cells. LMP1-positive NPC cells were indicated to be more sensitive to TRAIL compared with LMP1-negative NPC cells in three NPC cell lines. CNE-1 is a LMP1-negative NPC cell line that was transfected with pGL6-LMP1; following which, sensitivity to TRAIL decreased. LMP1-induced TRAIL resistance was associated with the decreased cleavage of caspase-8,-3 and -9, BH3 interacting domain death agonist (Bid) and mitochondrial depolarization, without any effects on the expression of the death receptors, B-cell lymphoma (Bcl)-2 and Bcl-extra long. Knockdown of XIAP with small interfering RNA increased caspase-3 and -9 and Bid cleavage, and prevented LMP1-induced TRAIL resistance. Furthermore, embelin, the inhibitor of XIAP, prevented LMP1-induced TRAIL resistance in the Epstein-Barr virus (EBV)-positive CNE-1-LMP1 and C666-1 NPC cell lines. However, embelin did not enhance TRAIL-induced apoptosis in NP-69, which was used as a benign nasopharyngeal epithelial cell line. These data show that LMP1 inhibits TRAIL-mediated apoptosis by upregulation of XIAP. Embelin may be used in an efficacious and safe manner to prevent LMP1-induced TRAIL resistance. The present study may have implications for the development and validation of novel strategies to prevent TRAIL resistance in EBV-positive NPC.

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“…Embelin has previously been shown to have antitumor, anti-inflammatory and analgesic properties (42). Embelin has also been identified as a small molecular inhibitor of XIAP (43).…”

Section: Discussionmentioning

confidence: 99%

Embelin prevents LMP1-induced TRAIL resistance via inhibition of XIAP in nasopharyngeal carcinoma cells

Yang¹,

Li²,

Yang³

et al. 2016

Oncology Letters

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“…Das suas partes aéreas foram isoladas, a benzoquinona embelina e também alguns alquil fenóis. A embelina mostrou atividade contra o T. cruzi, com 100% de lise dos protozoários, em uma concentração de 100 µg/mL (Feresin et al, 2003) …”

Section: (Figura 2)unclassified

Substâncias da natureza com atividade anti-Trypanosoma cruzi

Saúde-Guimarães¹,

Faria²

2007

Rev. bras. farmacogn.

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RESUMO:A doença de Chagas, uma zoonose causada por Trypanosoma cruzi, afeta em todo o mundo cerca de 16 a 18 milhões de pessoas. Sua transmissão ocorre através das fezes de triatomíneos, insetos hematófagos conhecidos como barbeiro. Atualmente, a principal forma de transmissão da doença de Chagas em áreas urbanas é por meio de transfusão de sangue contaminado. A violeta de genciana é o único agente que pode ser empregado na quimioprofi laxia de sangue destinado à transfusão. No entanto, existem algumas restrições ao seu uso. A quimioterapia disponível para a doença de Chagas não é efi caz uma vez que as drogas disponíveis nifurtimox e benznidazol são ativas apenas na fase aguda da doença e apresentam sérios efeitos colaterais. Várias substâncias isoladas de plantas foram avaliadas como agentes anti-T. cruzi, objetivando encontrar drogas com menos efeitos colaterais e maior efi cácia para a quimioprofi laxia e quimioterapia da doença de Chagas. Nesta revisão são apresentadas as substâncias de origem natural com atividade anti-T. cruzi.

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“…Furthermore, herbal monographs (of M/s Himalayan Drugs Company, Bengaluru) suggested that embelin is primarily effective against tapeworm and not roundworm or hookworm. The nematocidal activity of embelin has been explained by Mojumder and Mishra [53][54][55][56] against root-knot nematode (Meloidogyne incognita) with 90% mortality after exposure for 48 h (at 100 ppm concentration level). E. ribes seed oil demonstrated effective activity against Pheretima posthuma compared to standard piperazine citrate (10 mg/ml) was reported by Jalalpure et al…”

Section: Anthelmintic Activitymentioning

confidence: 99%

Embelin as a Potential Drug Molecule: A Review

Kumar¹,

Deshmukh²

2017

J Pharmacogn Nat Prod

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Embelia ribes are traditionally used medicinal remedies in India. Embelin is a hydroxyl benzoquinone with alkyl substitution and is considered as one of the main constituents. Embelin has various biological activities includes anticonvulsant, antidepressant, antidiabetic, antifertility, antitumor etc. This review is an overall overview of the existing pharmacology of E. ribes, helping to fuel further research in the various unexplored activities that are attributable to this plant.

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Bioactive alkyl phenols and embelin from Oxalis erythrorhiza

Cited by 83 publications

References 32 publications

Embelin prevents LMP1-induced TRAIL resistance via inhibition of XIAP in nasopharyngeal carcinoma cells

Embelin prevents LMP1-induced TRAIL resistance via inhibition of XIAP in nasopharyngeal carcinoma cells

Substâncias da natureza com atividade anti-Trypanosoma cruzi

Embelin as a Potential Drug Molecule: A Review

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