Bio-screening of a few green seaweeds from India for their cytotoxic and antioxidant potential

Vinayak, Rashmi C; Sudha, Sabu Appukuttan; Chatterji, Anil

doi:10.1002/jsfa.4490

Cited by 26 publications

(18 citation statements)

References 31 publications

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“…Previous studies highlighted greater antioxidant activities of the green seaweed C. racemosa from Malaysian North Borneo compared to other brown and red seaweeds, observing that the phenolic compounds were involved in the antioxidant activity [69]. Further studies conducted on C. racemosa highlighted that the major contributors to the antioxidant activities are medium polarity phenolic compounds [70,71]. The further identification, characterization, and isolation of the compounds involved in C. cylindracea antioxidant activity might contribute to the employment of algal extracts in disease treatments related to oxidative stress, taking into account that, recently, an interest in natural antioxidants has increased because they are safer than synthetic antioxidants.…”

Section: Discussionmentioning

confidence: 99%

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

et al. 2016

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Recently, there is a growing interest towards the development of strategies for invasive seaweed control and exploitation as source of secondary metabolites. Here, we investigated the potential of exploitation in biotechnology and recycling options in eradication programs of the lipidic extract of the Mediterranean invasive seaweed Caulerpa cylindracea (Chlorophyta). The chemical characterization was carried out by means of multinuclear and multidimensional NMR spectroscopy. The fatty acid profile of C. cylindracea assessed the presence of several types of molecules known for antioxidant activity such as carotenoids, chlorophylls, pheophytins, and sterols. The NMR spectroscopy showed also the characteristic signals of saturated, unsaturated, and free fatty acids as well as other metabolites including the biopolymer polyhydroxybutyrate. The lipidic extract exerted an antioxidant activity corresponding to 552.14 ± 69.13 mmol Trolox equivalent/g (ORAC) and to 70.3 ± 2.67 mmol Trolox equivalent/g (TEAC). The extract showed an antibacterial activity against several Vibrio species, suggesting its potential use in the control of diseases in mariculture. Our results show that C. cylindracea, representing a critical hazard in coastal areas, could be transformed into a gain supporting specific management actions to reduce the effects of human pressures.

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Section: Discussionmentioning

confidence: 99%

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

et al. 2016

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“…Green seaweeds contain high amounts of polyphenols such as catechin, epicatechin, epigallocatechin gallate, and gallic acid [29]. Phenolic compounds were noticed only in the chloroform extract.…”

Section: Gomathi and Shebamentioning

confidence: 99%

Phytochemical Screening and Heavy Metal Analysis of Ulva Reticulata

Gomathi

2018

Asian J Pharm Clin Res

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Objective: Ulva reticulata is a marine edible green seaweed widely distributed along the coastal lines of India. The present study was designed to screen the phytochemicals and evaluate heavy metals content of U. reticulata collected from Rameshwaram, Tamil Nadu, India, in the perspective of assessing their therapeutic value and/or safety in relation to its uses. Method:The seaweed sample was subjected to extraction with solvents of different polarities (methanol, ethanol, acetone, chloroform, and petroleum ether) and screened for phytochemicals according to standard methods. Heavy metal analysis was also performed with the dried sample powder using inductively coupled plasma optical emission spectrophotometer (ICP-OES).Result: Preliminary phytochemical analysis revealed the presence of reducing sugar, proteins, flavonoids, glycosides, alkaloids, and anthraquinones. ICP-OES indicated the seaweed to contain relative amount of heavy metals in the order of iron (Fe) > chromium (Cr) > Zinc (Zn) > nickel (Ni) > copper (Cu) > lead (Pb) -cadmium (Cd) and is within the permissible limits set by the WHO/FAO, except Fe and Cr. Conclusion:The different solvent extracts of U. reticulata showed the presence of the number of phytochemicals. Furthermore, the present study has revealed the presence of heavy metals in U. reticulata which can be a representative picture of the dissolved metals in the aquatic phase.

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“…Other compounds in the crude extract and fractions, such as proteins and polysaccharides, are known for their BIOLOGICAL ACTIVITIES OF THE Palythoa caribaeorum ability to chelate metals. Such activity is evidenced by their inhibitory effect on the absorption of ferrous ions (Palmer et al 2009, Vinayak et al 2011.…”

Section: Total Phenolic Content (Tpc)mentioning

confidence: 99%

“…This ability indicates that the antioxidant compounds are electron donors and could reduce the oxidized intermediate of lipid peroxidation processes, thus acting as primary and secondary antioxidants (Vinayak et al 2011).…”

Section: +mentioning

confidence: 99%

Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum

Alencar

Melo

Silva

et al. 2015

An. Acad. Bras. Ciênc.

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Marine invertebrates are capable of synthesizing bioactive compounds, which may be beneficial to human health. The aim of this study was to evaluate the antioxidant, hemolytic, antimicrobial and cytotoxic activities of crude extract (70% EtOH), and dichloromethane (DCM), ethyl acetate (EtOAc), and aqueous (Aq) fractions of the marine zoanthid Palythoa caribaeorum. The phenolic compound contents of the crude extract, DCM, EtOAc and Aq fractions were 12.33, 18.17, 10.53, and 3.18 mg GAE per gram, respectively. DPPH radical scavenging activity showed slight variation. IC 50 of crude extract, DCM, EtOAc and Aq fractions were 11.13, 11.25, 11.74, and 11.28 µg mL -1 , respectively. Among the sample, ferrous ion chelating was the highest in crude extract (IC 50 302.90 µg mL -1 ), followed by EtOAc, Aq, and DCM fractions with 457.77, 547.91, and 641.82 µg mL -1 , respectively. Ferric-reducing antioxidant power showed optical density at about 0.5. The samples tested exhibited low hemolytic activity under 10% up to a concentration of 50 μg mL -1 . No antimicrobial activity was observed against any of the tested bacterial strains. For the cytotoxic activity, LC 50 of DCM, crude extract, EtOAc, and Aq were 52.10, 83.06, 86.34, and 117.45 μg mL -1 , showing high toxicity.

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Bio-screening of a few green seaweeds from India for their cytotoxic and antioxidant potential

Abstract: The underlying results endorse seaweeds as a rich, novel source of antioxidant compounds needing systemic exploration.

Cited by 26 publications

References 31 publications

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

The Potential Exploitation of the Mediterranean Invasive Alga Caulerpa cylindracea: Can the Invasion Be Transformed into a Gain?

Phytochemical Screening and Heavy Metal Analysis of Ulva Reticulata

Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum

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