Bio-inspired microcapsule for targeted antithrombotic drug delivery

Ye, Wei; Wang, Nan; Hu, Kebang; Zhang, Lincai; Liu, Aihui; Pan, Changjiang; Gong, Tao; Liu, Tao; Ding, Hongyan

doi:10.1039/c8ra04273j

Cited by 14 publications

(13 citation statements)

References 42 publications

(44 reference statements)

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“…None reported [49] Urokinase-loaded cRGD-bound liposomes cRGD Mouse mesenteric thrombosis model [73] tPA-loaded cRGD-bound PEG-nanovesicle cRGD None reported [69] Fibrin-targeted Streptokinase-bound/loaded liposome Monoclonal antibody FnI-3C Rat thrombosis model [75] tPA-loaded fbrin-specifc nanogels…”

Section: Whole Fbrinogen Moleculesmentioning

confidence: 99%

Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies

Sheridan

Brown

2023

Journal of Tissue Engineering and Regenerative Medicine

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Myocardial infarction, stroke, and pulmonary embolism are all deadly conditions associated with excessive thrombus formation. Standard treatment for these conditions involves systemic delivery of thrombolytic agents to break up clots and restore blood flow; however, this treatment can impact the hemostatic balance in other parts of the vasculature, which can lead to excessive bleeding. To avoid this potential danger, targeted thrombolytic treatments that can successfully target thrombi and release an effective therapeutic load are necessary. Because activated platelets and fibrin make up a large proportion of clots, these two components provide ample opportunities for targeting. This review will highlight potential thrombus targeting mechanisms as well as recent advances in thrombolytic therapies which utilize blood cells and clotting proteins to effectively target and lyse clots.

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Section: Whole Fbrinogen Moleculesmentioning

confidence: 99%

Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies

Sheridan

Brown

2023

Journal of Tissue Engineering and Regenerative Medicine

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“…Examples might include the value of high sensitivity troponin assays to guide the management of peripheral arterial disease or methods for local, rather than systemic, antithrombotic therapy. 13 , 14 , 15 As with the previous types of reviews they need to be systematic and thorough, but unlike systematic or scoping reviews, they are guided by the literature and make more use of conference abstracts and grey literature such as scientific and charitable foundation reports, and government or industry reports. The review should report not just specific outcomes but must include the key present and future issues and/or challenges, which need to be addressed.…”

Section: What Is a Topical Review And When Is It Needed?mentioning

confidence: 99%

Systematic Reviews of the Literature Are Not Always Either Useful Or the Best Way To Add To Science

Powell

Koelemay

2022

EJVES Vascular Forum

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“…The utilization of PDA hollow capsules to deliver nattokinase for the antithrombotic purpose was recently reported. [68] In this work, the encapsulated nattokinase was regularly released from PDA microcapsules to dissolve fibrin clots.…”

Section: Hollow Pda Structuresmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Tran

Batul

Bhave

et al. 2019

Biotechnology Journal

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Since the first time mussel‐inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA‐based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.

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Bio-inspired microcapsule for targeted antithrombotic drug delivery

Abstract: NK-loaded hollow microcapsules were fabricated and assessed as a potential antithrombosis therapy.

Cited by 14 publications

References 42 publications

Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies

Recent Advances in Blood Cell-Inspired and Clot-Targeted Thrombolytic Therapies

Systematic Reviews of the Literature Are Not Always Either Useful Or the Best Way To Add To Science

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

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