Bio-availability and metabolism of n-3 fatty acid rich garden cress (Lepidium sativum) seed oil in albino rats

Diwakar, B; Dutta, Priyanka; Lokesh, Belur R.; Naidu, K. Akhilender

doi:10.1016/j.plefa.2007.12.001

Cited by 50 publications

(37 citation statements)

References 41 publications

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“…ALA content was significantly increased in GCO and GCO blended oil fed groups and these results are in agreement with earlier reports that feeding of ALA and ALA blended oils accumulate ALA in adipose tissue (Chopra & Sambaiah, 2009;Diwakar et al, 2008;Ramprasad et al, 2010). However, elongation of ALA to LCPUFAs is restricted in adipose due to lack of desaturase enzymes.…”

Section: Discussionsupporting

confidence: 93%

“…Garden cress seeds have not been commercially exploited as an alternate source of ALA rich oil. Earlier, we have reported physicochemical properties of GCO (Diwakar, Dutta, Lokesh, & Naidu, 2010), bio-availability and metabolism of GCO in albino rats (Diwakar, Dutta, Lokesh, & Naidu, 2008), immunomodulatory efficacy of GCO (Diwakar, Lokesh, & Naidu, 2011) and safety evaluation of Garden cress seeds in Wistar rats (Dutta, Diwakar, Viswanatha, Murthy, & Naidu, 2011). In this study, we have investigated the effect of GCO blends with commonly consumed n-6 PUFA rich vegetable oils (SFO, RBO, SESO) to decrease n-6/n-3 ratio and also understand the possible modulatory effect of these blended oils on lipid metabolism in experimental rats.…”

Section: Introductionmentioning

confidence: 99%

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Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Umesha

Naidu

2012

Food Chemistry

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Umesha

Naidu

2012

Food Chemistry

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“…The positive effect on bone density of LS is probably due to its rich content of calcium (Gokavi et al, 2004), and on its ability to increase serum and liver alpha linolenic acid (ALA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) (Diwakar et al, 2008), which have been shown to have beneficial effects on bone (Kruger et al, 1998). These results are in accordance with previously reported benefits of LS seeds that induced a marked influence on fracture healing in rabbits (Juma 2007).…”

Section: Discussionsupporting

confidence: 87%

Synergistic antiosteoporotic effect of <i>Lepidium Sativum</i> and alendronate in glucocorticoid-induced osteoporosis in wistar rats

Elshal

Al-Malki

Hussein

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Alendronate belongs to a class of drugs called bisphosphonates. Bisphosphonates (BP) therapy is a vital option to reduce the risk of bone fracture in people who suffer from osteoporosis. Yet, bisphosphonate have displayed several side effects. Lepidium sativum (LS) seeds have been used in traditional folk medicine to heal fractured bones. However, there is a dearth of information on the impact of LS on bone metabolism especially in cases of glucocorticoids induced osteoporosis. Therefore, the aim of the study was to compare the biochemical bone markers and histological responses of LS alone (6 g of LS seeds in diet daily, n=8), ALD (alendronate, 70 mg/kg s.c.; n=8) alone, or LS and ALD combined in a rat model of glucocorticoid-induced osteoporosis (GIO) by injecting rats with methylprednisolone 3.5 mg/kg per day for 4 weeks. Serum calcium (Ca), albumin, phosphorus (P), bone-specific alkaline phosphatase (b-ALP), and tartrate-resistant acid phosphatase (TRAP) were measured 4 weeks after induction of GIO. GIO-group showed significantly increased serum TRAP and decreased b-ALP. GIO-group also showed significantly decreased serum P and unaltered Ca concentrations. Histological examination of GIO-group tibia bones indicated an osteoporotic change and a concomitant decrease in percentage of trabecular area or bone marrow area (PTB) in the proximal femoral epiphysis. Treatment with either LS and/or ALD ameliorated the above mentioned changes with variable degrees, with a net results of enhanced serum calcium, bone architecture, PTB, b-ALP and decreased TRAP in LS and LS+ALD groups compared to that of animals treated with alendronate alone. In conclusion, our findings present evidence supporting the potential benefits of LS in reducing the burden of GCs on bone health.

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“…29 Glucosinolates, a class of thioglycosides, are major secondary metabolites of Euphorbia hirta leaves and leaves 30 and have been shown to inhibit carcinogenesis and have chemopreventive effects against the development and proliferation of cancers. 6 As presented above, some researchers have shown that certain constituents of the Euphorbia hirta plant and the alcoholic extracts of its different parts have chemopreventive and anti-cancer effects, but, to our …”

Section: Introductionmentioning

confidence: 82%

Apoptosis and Necrosis of Human Breast Cancer Cells by an Aqueous Extract of Euphorbia hirta leaves

Behera¹,

Dash²,

Pradhan³

et al. 2016

JYP

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Introduction: Traditional medicines for mammary tumour are unreasonable and have genuine symptoms. Non-ordinary normal medications have increased wide acknowledgment because of their assurance of a cure with negligible or no symptoms, however minimal experimental confirmation exists. One such basic cure is the leaves of the Euphorbia hirta plant. Methods: It is initially reported utilization of the fluid concentrate of Euphorbia hirta leaves breast cancer cells. The capacity of the concentrate to impel apoptosis and corruption in the human bosom malignancy cell line MCF-7, contrasted with typical human skin fibroblasts (MDA MB-231), was dictated by morphological changes in the cells utilizing light microscopy, DNA fragmentation, and brilliant stains (Annexin V and Propidium Iodide) utilizing Flow Cytometry and fluorescent microscopy. Results: Apoptosis was instigated in both cells, and more in MCF-7, when they were treated with 25% and half concentrate, while rot was watched mostly after presentation to raised concentrate fixations (75%). DNA discontinuity came about for both cells, in a period and dosage subordinate way. Both cells, at all concentrate fixations, demonstrated no critical contrasts in the quantity of living, dead, apoptotic, and necrotic cells. Conclusion: At long last, the outcomes might show that apoptotic changes in MCF-7 might be free of caspase-3, which is included in apoptosis and is inadequate in MCF-7 cells.

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Bio-availability and metabolism of n-3 fatty acid rich garden cress (Lepidium sativum) seed oil in albino rats

Cited by 50 publications

References 41 publications

Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Synergistic antiosteoporotic effect of <i>Lepidium Sativum</i> and alendronate in glucocorticoid-induced osteoporosis in wistar rats

Apoptosis and Necrosis of Human Breast Cancer Cells by an Aqueous Extract of Euphorbia hirta leaves

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