Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Umesha, S.S.; Naidu, K. Akhilender

doi:10.1016/j.foodchem.2012.05.118

Cited by 51 publications

(29 citation statements)

References 29 publications

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“…Serum total-cholesterol and LDL-cholesterol decreased by 8% and 12%, respectively, in the ALA group after supplementation -similar effects have been observed in previous studies using ALA-rich oils (Bemelmans et al, 2002;Finnegan et al, 2003b;Södergren et al, 2001;Umesha & Naidu, 2012;Zhao et al, 2004). ALA has a limited capacity for conversion into longer-chain n-3 fatty acids, such as EPA, DPA and DHA.…”

Section: Discussionsupporting

confidence: 84%

Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Kim

Lee

Lee³

et al. 2016

Journal of Functional Foods

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Section: Discussionsupporting

confidence: 84%

Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Kim

Lee

Lee³

et al. 2016

Journal of Functional Foods

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“…Moreover, treatment with flavonoid and sapogenin extracts of LS lowered TC, TAG, LDL-c and AI values in hyperlipidemic rats (Shukla et al, 2015). Also, hypolipidemic and hypocholesterolemic effects of LS were mentioned by Umesha and Naidu (2012) and Althnaian (2014). The hypolipidemic effect of LS might be due to inhibition of absorption and enhanced excretion of lipids through the gastrointestinal tract (Chauhan et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Mohamed¹,

Safwat²

2016

Beni-Suef University Journal of Basic and Applied Sciences

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Available onlineA B S T R A C T 5-fluorouracil (5-FU) is a chemotherapeutic agent used for treatment of solid tumors.Cardiotoxicity is a major complication of 5-FU therapy. Therefore, the aim of the present study was to evaluate the possible cardioprotective potency of Lepidium sativum seed powder (LS) against 5-FU-induced cardiotoxicity and oxidative stress in albino rats. The rats were divided into three groups. Rats in the control group received saline daily for 8 days only.Rats in FU-treated group received saline orally for 8 days, then I.P. injected with 5-FU (150 mg\kg B.W) on the 5th day. Rats in LS-treated group were orally dosed with LS (550 mg\kg B.W\day) for 8 days, and on the 5th day rats were administrated with the same previous dose of 5-FU. 5-FU induced cardiotoxicity was assessed by a significant increase in serum concentrations of cTnI, CK-MB, lipid profile and a moderate elevation of cardiac MDA. 5-FU significantly decreased serum HDL-c and GSH concentration in cardiac homogenate. Its administration also resulted in the release of some inflammatory markers such as myeloperoxidase and Interleukin-1β (IL-1β). All 5-FU altered parameters were markedly ameliorated by LS pre-co-post-treatment. Results of the present study suggest that LS has a significant effect on the protection of the heart against 5-FU-induced cardiotoxicity through maintaining the antioxidant and anti-inflammatory activities.

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“…43,46,47 In this study, it was clearly revealed that the level of PSO increased and the values of TG, TC, and LDL-C decreased in the PSO group. 43,46,47 In this study, it was clearly revealed that the level of PSO increased and the values of TG, TC, and LDL-C decreased in the PSO group.…”

Section: Discussionmentioning

confidence: 52%

Anti-diabetic activity of peony seed oil, a new resource food in STZ-induced diabetic mice

Wang

et al. 2015

Food Funct.

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This study was conducted to investigate the components of a new resource food in China, peony seed oil (PSO) by GC-MS (gas chromatography-mass spectrometry), its inhibitory effects on carbohydrate hydrolyzing enzymes in vitro and its anti-diabetic effects on mice induced by streptozotocin (STZ). The results showed that peony seed oil showed weak anti-α-amylase activity; however, strong anti-α-glucosidase activity was noted. The GC-MS analysis of the oil showed 9 constituents of which α-linolenic acid was found to be the major component (38.66%), followed by linoleic acid (26.34%) and oleic acid (23.65%). The anti-diabetic potential of peony seed oil was tested in STZ induced diabetic mice. Administration of peony seed oil and glibenclamide reduced the blood glucose level and the area under curve (AUC) in STZ induced diabetic mice. There were significant increases in body weight, liver glycogen content, serum insulin level, high-density lipoprotein cholesterol (HDL-C) and decreases in glycosylated hemoglobin (HbA1C), total serum cholesterol (TC), and triglyceride (TG) in test groups as compared to the untreated diabetic groups. In vivo antioxidant studies on STZ induced diabetic mice revealed the reduction of malondialdehyde (MDA) and increase of glutathione peroxides (GSH-px), superoxide dismutase (SOD), and glutathione (GSH). The results provided a sound rationale for future clinical trials of oral administration of peony seed oil to alleviate postprandial hyperglycemia in streptozotocin-induced diabetic mice.

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Vegetable oil blends with α-linolenic acid rich Garden cress oil modulate lipid metabolism in experimental rats

Cited by 51 publications

References 29 publications

Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA 2 activity in non-diabetic and hypercholesterolaemic subjects

Evaluation of cardioprotective activity of Lepidium sativum seed powder in albino rats treated with 5-fluorouracil

Anti-diabetic activity of peony seed oil, a new resource food in STZ-induced diabetic mice

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