Bio-active cements-Mineral Trioxide Aggregate based calcium silicate materials: a narrative review

Zafar, Kamil; Jamal, Shizrah; Ghafoor, Robia

doi:10.5455/jpma.16942

Cited by 29 publications

(40 citation statements)

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“…MTA is the preferred material to be used for direct pulp capping. It was found that the use of MTA as a direct pulp capping agent, it shows a far better result with respect to complete formation of dentin bridge and decreasing inflammation, in comparison with Dycal (calcium hydroxide) [30]. Other studies on MTA show that it is characterized by the ability to bind in the presence of water, good tightness and bioactivity [25].…”

Section: Discussionmentioning

confidence: 99%

The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages

Barczak

Palczewska-Komsa

Lipski

et al. 2020

IJMS

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The aim of the present study was to investigate the new silicate cement mineral trioxide aggregate (MTA Repair HP) with respect to its effect on the inflammation process involving the tooth and periodontal tissues. The composition of MTA Repair HP was supplemented with plasticizer agents which can have a negative effect on the modulation of tooth inflammation. The silicate-based material in question is widely used in regeneration of the pulp-dentin complex, treatment of perforations of various locations in the tooth, as well as in surgical treatment of the complications of periapical tissue. The improved bioceramic restorative cement can affect the expression of metalloproteinases MMP-2 and MMP-9 in monocytes/macrophages involved in modulation of inflammation and regenerative processes of the tooth and periodontal tissues. The novel aspect of the present study lies in the application of the model of THP-1 monocyte/macrophage and applying the biomaterial in direct contact with the cells. Hence, it provides a representation of clinical conditions with respect to regenerative pulp and periodontal treatment with the use of MTA Repair HP. A lack of macrophage activation (as measured with flow cytometry) was found. Moreover, the study identified a lack of expression stimulation of the studied metalloproteinases (with the use of Western blotting and fluorescent microscopy). Similarly, no increase in MMP-2 and MMP-9 concentration was found (measured by ELISA method) in vitro when incubated with MTA Repair HP. Based on the results it can be concluded that new MTA Repair HP does not increase the inflammatory response in monocytes/macrophages associated with the activity of the described enzymes. It can also be speculated that they do not affect the process of dentin regeneration in which MMP-2 and MMP-9 play significant roles.

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Section: Discussionmentioning

confidence: 99%

The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages

Barczak

Palczewska-Komsa

Lipski

et al. 2020

IJMS

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“…A good curettage of the residual bone cavity, the instrumentation, and the seal with MTA have certainly helped to determine an improvement in bone quality and speed of healing. The properties of the MTA are widely supported by several articles in the most recent review [ 17 ]. The limits of this protocol are related to the formation of a prepared team (assistant, nurse, etc.)…”

Section: Discussionmentioning

confidence: 99%

B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) Used for the Treatment of a Persistent Great Periapical Lesion of an Endodontically Treated Tooth: A New Therapeutic Option

Viganò

Disconzi

Bertini

et al. 2020

Case Reports in Dentistry

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The aim of this case report was to evaluate the efficacy of a new platelet-rich plasma preparation and its regenerative capacity of bone periapical tissue for the treatment of a very compromised endodontic treated tooth, with a periapical lesion of 1.5 cm in diameter, using a pure platelet concentrate. This is made without the use of anticoagulant or any type of activator, e.g., bovine thrombin, calcium chloride. For this reason, it has been called “Pure”; it is the B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) designed and developed by Dr. Raffaello Viganò. The patient has read and signed a written consent form. The study protocol was approved by the Ethics Committee for Human Studies, University of Varese. X-ray at 2 and 6 months and 4 years after endodontic surgery demonstrated the success of the treatment.

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“…MTA is newer to the commercial market than Ca(OH) 2 , although has been used for pulp capping since the 1990s (Zafar et al, 2020), and is thought to have higher success rates than Ca(OH) 2 (da Rosa et al, 2018b;Paula et al, 2018;. Moisture is required for MTA to set and, when water is added, a colloidal gel composed of calcium oxide crystals is formed (calcium silicate hydrate) and Ca(OH) 2 is released, imparting much of the MTA's known antimicrobial activity (Zafar et al, 2020). MTA liberates numerous growth factors from dentine during pulp capping (Tomson et al, 2017).…”

Section: Pulp-capping Materialsmentioning

confidence: 99%

“…MTA liberates numerous growth factors from dentine during pulp capping (Tomson et al, 2017). Although MTA would appear to be a good PCA based upon the success rates, there are numerous issues with its use, for example, long setting times (> 2 h for some brands), discolouration of teeth, poor handling characteristics (due to its crumbly nature), risk of pulpal obliteration and high cost (Linsuwanont et al, 2017;Qureshi et al, 2014;Zafar et al, 2020). Due to the release of Ca(OH) 2 , MTA also has high alkalinity, which again is cytotoxic (Kim et al, 2019;Youssef et al, 2019).…”

Section: Pulp-capping Materialsmentioning

confidence: 99%

Bioactive molecules for regenerative pulp capping

Whitehouse¹,

Thomson²,

et al. 2021

eCM

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Since the discovery of bioactive molecules sequestered in dentine, researchers have been exploring ways to harness their activities for dental regeneration. One specific area, discussed in this review, is that of dental-pulp capping. Dental-pulp caps are placed when the dental pulp is exposed due to decay or trauma in an attempt to enhance tertiary dentine deposition. Several materials are used for dental-pulp capping; however, natural biomimetic scaffolds may offer advantages over manufactured materials such as improved aesthetic, biocompatibility and success rate. The present review discusses and appraises the current evidence surrounding biomimetic dental-pulp capping, with a focus on bioactive molecules sequestered in dentine. Molecules covered most extensively in the literature include transforming growth factors (TGF-βs, specifically TGF-β1) and bone morphogenetic proteins (BMPs, specifically BMP-2 and BMP-7). Further studies would need to explore the synergistic use of multiple peptides together with the development of a tailored scaffold carrier. The roles of some of the molecules identified in dentine need to be explored before they can be considered as potential bioactive molecules in a biomimetic scaffold for dental-pulp capping. Future in vivo work needs to consider the inflammatory environment of the dental pulp in pulpal exposures and compare pulp-capping materials.

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Bio-active cements-Mineral Trioxide Aggregate based calcium silicate materials: a narrative review

Cited by 29 publications

References 0 publications

The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages

The Influence of New Silicate Cement Mineral Trioxide Aggregate (MTA Repair HP) on Metalloproteinase MMP-2 and MMP-9 Expression in Cultured THP-1 Macrophages

B.P.F.C.® Bio-Plasma® with Pure Growth Factors (BioPlasma®) Used for the Treatment of a Persistent Great Periapical Lesion of an Endodontically Treated Tooth: A New Therapeutic Option

Bioactive molecules for regenerative pulp capping

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