Binding characteristics of imidazolium-based ionic liquids with calf thymus DNA: Spectroscopy studies

Pressure-Dependent Stability of Imidazolium-Based Ionic Liquid/DNA Materials Investigated by High-Pressure Infrared Spectroscopy

“…Cations with a longer alkyl side chain may lead to larger binding forces with DNA. This observation is consistent with the arguments reported in the literature [22,35]. In other words, the difference in alkyl side chain lengths may cause various effects on the stabilization of IL/DNA associations at high pressures.…”

“…The alkyl side chain of an imidazolium cation may participate in aggregation and association with anions in bulk ILs, although the hydrophilic and Coulomb forces remain the dominant interactions [11][12][13][14][15]. On top of that, several reports [17][18][19][20][21][22][23][24] show that the hydrophobic alkyl chains can stabilize biopolymers like nucleic acids via forming the association through electrostatic interactions between the DNA molecule and cations of IL.DNA molecules can associate with cations of IL via the negatively charged backbone and hydrophobic groove interaction of DNA [19][20][21][22][23][24]. The cluster structure of ILs can be disturbed by mixing with an additive-like DNA via electrostatic interaction between the cation head group of ILs and phosphate anion of DNA and hydrophobic association between the alkyl part of IL cation and the groove region or nitrogenous base of DNA [19][20][21][22][23][24].…”

“…Part of base pairs (pyrimidine and purine), which interact via hydrogen bonding and stacking, are easily attracted to alkyl tail of ILs with noncovalent interaction, hydrophobic interaction, or van der Waals force. Several researchers [19][20][21][22] have suggested that the chemical structure of the cationic head group of ILs determines the electrostatic interaction to a certain extent, whereas the alkyl chain length of the cation is responsible for the stability of groove association. Ghoshdastidar et al [25] have reported that ILs can rescue DNA by forming a complex via specific trapping force in water solutions.…”

“…The alkyl side chain of an imidazolium cation may participate in aggregation and association with anions in bulk ILs, although the hydrophilic and Coulomb forces remain the dominant interactions [11][12][13][14][15]. On top of that, several reports [17][18][19][20][21][22][23][24] show that the hydrophobic alkyl chains can stabilize biopolymers like nucleic acids via forming the association through electrostatic interactions between the DNA molecule and cations of IL.…”

“…DNA molecules can associate with cations of IL via the negatively charged backbone and hydrophobic groove interaction of DNA [19][20][21][22][23][24]. The cluster structure of ILs can be disturbed by mixing with an additive-like DNA via electrostatic interaction between the cation head group of ILs and phosphate anion of DNA and hydrophobic association between the alkyl part of IL cation and the groove region or nitrogenous base of DNA [19][20][21][22][23][24]. Part of base pairs (pyrimidine and purine), which interact via hydrogen bonding and stacking, are easily attracted to alkyl tail of ILs with noncovalent interaction, hydrophobic interaction, or van der Waals force.…”