Fundamental importance of ionic interactions in the liquid phase: A review of recent studies of ionic liquids in biomedical and pharmaceutical applications

Egorova, Ksenia S.; Ananikov, Valentine P.

doi:10.1016/j.molliq.2018.09.025

Cited by 142 publications

(78 citation statements)

References 305 publications

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“…Ionic Liquids (ILs), though mostly known for their potential role as “green solvents”, are becoming increasingly attractive as easily customizable and tunable organic salts for diverse specific purposes (task-specific ILs). There is an infinity of possibilities when combining organic cations with organic or inorganic anions, enabling production of ILs with diverse structural, physical and chemical properties [ 1 ] that can be adapted to the demands of areas as diverse as material sciences [ 2 ], biotechnology [ 3 ], or biomedicine [ 4 ]. Moreover, by making use of bioactive ions, ILs displaying relevant biological activities [ 5 ] can be produced, for instance, as anticancer [ 6 ], antimalarial [ 7 ], and antimicrobial agents [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

Gomes

Bessa

Correia

et al. 2020

IJMS

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A covalent conjugate between an antibacterial ionic liquid and an antimicrobial peptide was produced via “click” chemistry, and found to retain the parent peptide’s activity against multidrug-resistant clinical isolates of Gram-negative bacteria, and antibiofilm action on a resistant clinical isolate of Klebsiella pneumoniae, while exhibiting much improved stability towards tyrosinase-mediated modifications. This unprecedented communication is a prelude for the promise held by ionic liquids -based approaches as tools to improve the action of bioactive peptides.

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Section: Introductionmentioning

confidence: 99%

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

Gomes

Bessa

Correia

et al. 2020

IJMS

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“…For mechanistic reasons, this may be because the cytotoxicity of ILs is related to the lipophilic effect. [28] The lipophilicity increases as the length of the cationic chain increases, making the ILs molecules easily penetrate the cell membrane, [29] which indicates enhanced toxicity. In addition, when the toxicities of two ILs with the same anion and only different number of oxygen atoms of cation were compared, it can be found that the ILs with a higher number of oxygen atoms were less toxic.…”

Section: Resultsmentioning

confidence: 99%

Estimation of Ionic Liquids Toxicity against Leukemia Rat Cell Line IPC‐81 based on the Empirical‐like Models using Intuitive and Explainable Fingerprint Descriptors

Chen

et al. 2020

Molecular Informatics

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Ionic liquids as green solvents have been paid extensive attention in recent years. However, mostly it is cost and time-consuming to measure their properties. Thus, theorical methods, especially ultrafast chemoinformatics methods were introduced into these studies. Instead of abstract and complex models in some QSPR studies, in this study, the 2D structural features related to the toxicity of ionic liquids were discussed at first, and then the corresponding intuitive and meaningful descriptors were suggested to construct quantitative chemoinformatics models, finally a multiple linear regression (MLR) based on the empirical-like models were applied to the estimation of toxicities of 304 ionic liquids. For the test sets, the relationship coefficients reached up to R = 0.90. An external test set of 11 ionic liquids collected from other literatures was submitted to the achieved MLR equations, and the satisfactory result (R = 0.94) was obtained.

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“…Nanoemulsions are kinetically but not thermodynamically stable, and their preparation requires expensive, high-energy input methods as they are formed with relatively small amounts of surfactants (Montenegro et al 2016). The efficacy of nanoemulsions is enhanced by the nature and type of surfactant and cosurfactant used (Hussan 2011).…”

Section: Nanoemulsionsmentioning

confidence: 99%

Transdermal delivery systems in cosmetics

et al. 2020

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Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains a limiting factor in the penetration and absorption of these actives. Enhancement via modification of the stratum corneum by hydration, acting of chemical enhancers on the structure of stratum corneum lipids, and partitioning and solubility effects are described. This review summarizes the advances in the development and mechanisms of action of chemical components that act as permeation enhancers, as well as the advances in appropriate vehicles, such as gels, emulsions, and vesicular delivery systems, that can be used for effective transdermal delivery.

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Fundamental importance of ionic interactions in the liquid phase: A review of recent studies of ionic liquids in biomedical and pharmaceutical applications

Cited by 142 publications

References 305 publications

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

“Clicking” an Ionic Liquid to a Potent Antimicrobial Peptide: On the Route towards Improved Stability

Estimation of Ionic Liquids Toxicity against Leukemia Rat Cell Line IPC‐81 based on the Empirical‐like Models using Intuitive and Explainable Fingerprint Descriptors

Transdermal delivery systems in cosmetics

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