Bile Salt Anion Sorption by Polymeric Resins: Comparison of a Functionalized Polyacrylamide Resin with Cholestyramine

Zhu, Xuhai; Brizard, F.; Piché, Jessica; Yim, C. T.; Brown, G. R.

doi:10.1006/jcis.2000.7157

Cited by 18 publications

(8 citation statements)

References 25 publications

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“…21 Zhu and co-workers also showed that deoxycholates better compete for adsorption by resins than cholates. 29 Therefore, this corroborates that the hydrophobicity plays a key role in these interactions. Finally, the trend of the effect of substituent type of cellulose ethers in the presence of the new bile salt, NaTC, agrees with that seen in section 3.1.…”

Section: Effect Of the Bile Salt Typesupporting

confidence: 68%

Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts

et al. 2015

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Some known mechanisms proposed for the reduction of blood cholesterol by dietary fibre are: binding with bile salts in the duodenum and prevention of lipid absorption, which can be partially related with the bile salt binding. In order to gain new insights into the mechanisms of the binding of dietary fibre to bile salts, the goal of this work is to study the main interactions between cellulose derivatives and two types of bile salts. Commercial cellulose ethers: methyl (MC), hydroxypropyl (HPC) and hydroxypropylmethyl cellulose (HPMC), have been chosen as dietary fibre due to their highly functional properties important in manufactured food products. Two types of bile salts: sodium taurocholate (NaTC) and sodium taurodeoxycholate (NaTDC), have been chosen to understand the effect of the bile salt type. Interactions in the bulk have been investigated by means of differential scanning calorimetry (DSC) and linear mechanical spectroscopy. Results show that both bile salts have inhibitory effects on the thermal structuring of cellulose ethers and this depends on the number and type of substitution in the derivatised celluloses, and is not dependent upon molecular weight. Concerning the bile salt type, the more hydrophobic bile salt (NaTDC) has greater effect on these interactions, suggesting more efficient adsorption onto cellulose ethers. These findings may have implications in the digestion of cellulose-stabilised food matrices, providing a springboard to develop new healthy cellulose-based food products with improved functional properties.

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Section: Effect Of the Bile Salt Typesupporting

confidence: 68%

Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts

et al. 2015

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“…Drugs that are known to be affected by this mechanism are furosemide, warfarin, phenprocoumon, sulindac, cerivastatin, levothyroxine, glipizide, mycophenolic acid, folic acid and valproate . The binding affinity for coadministered drugs can vary among the different BAS, for example, cholestyramine, which has a high affinity for hydrophobic compounds, decreased ibuprofen and diclofenac absorption to a higher extent than colestipol; while colesevelam has a favourable DDI‐profile compared to other BAS …”

Section: Medicines Used To Treat Gastrointestinal Diseases and Their mentioning

confidence: 99%

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Litou

Effinger

Kostewicz

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives Drugs used to treat gastrointestinal diseases (GI drugs) are widely used either as prescription or over-the-counter (OTC) medications and belong to both the 10 most prescribed and 10 most sold OTC medications worldwide. The objective of this review article is to discuss the most frequent interactions between GI and other drugs, including identification of the mechanisms behind these interactions, where possible.Key findings Current clinical practice shows that in many cases, these drugs are administered concomitantly with other drug products. Due to their metabolic properties and mechanisms of action, the drugs used to treat gastrointestinal diseases can change the pharmacokinetics of some coadministered drugs. In certain cases, these interactions can lead to failure of treatment or to the occurrence of serious adverse events. The mechanism of interaction depends highly on drug properties and differs among therapeutic categories. Understanding these interactions is essential to providing recommendations for optimal drug therapy. Summary Interactions with GI drugs are numerous and can be highly significant clinically in some cases. While alterations in bioavailability due to changes in solubility, dissolution rate, GI transit and metabolic interactions can be (for the most part) easily identified, interactions that are mediated through other mechanisms, such as permeability or microbiota, are less well-understood. Future work should focus on characterising these aspects.

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“…Highly disperse amorphous silicas are distinguished for their high degree of purity; sufficient hydrolytic, thermal, radiation, and microbiologic stability. Siliceous adsorbents do not swell in contact with various solvents and biologic fluids, owing to which the adsorption equilibrium on their surface is attained considerably faster than in the case of polymer resins [4,6,7]. However, silanol groups on the surface of silica are weakly acidic [4,[8][9][10] so that the adsorption of organic acids (in particular bile acids) on silica cannot be expected to be considerable in a wide interval of pH.…”

Section: Introductionmentioning

confidence: 99%

Designing of the centers for adsorption of bile acids on a silica surface

Belyakova

Besarab

Roik

et al. 2006

Journal of Colloid and Interface Science

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Bile Salt Anion Sorption by Polymeric Resins: Comparison of a Functionalized Polyacrylamide Resin with Cholestyramine

Cited by 18 publications

References 25 publications

Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts

Effect of substituent pattern and molecular weight of cellulose ethers on interactions with different bile salts

Effects of medicines used to treat gastrointestinal diseases on the pharmacokinetics of coadministered drugs: a PEARRL Review

Designing of the centers for adsorption of bile acids on a silica surface

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