Bilateral posterior semi‐circular canal obliteration surgery for refractory benign paroxysmal positional vertigo (BPPV) in three patients

The hypolipidemic effects of peptides prepared from Cicer arietinum in ovariectomized rats and HepG2 cells

“…A new study has found that bile acid is an important signaling molecule in lipids metabolism. It can activate the expression of LXRs, and inhibit cholesterol synthesis in liver . It was also observed that LXR agonists produced uninvited hypertriglyceridemia and fatty liver by upregulating SREBP‐1 .…”

Novel middle ear applications for a synthetic cerebrospinal fluid (CSF) sealant

“…He has also successfully used TPD to cover semicircular canal fenestrations and round windows to prevent perilymph leakage. To prevent displacement of the bone pate used to plug the posterior semicircular canal in intractable BPPV, an additional layer of TPD over the temporalis fascia has been used by the senior author since 2010 (Figure ). Our experience would suggest it is a material that can be used safely and successfully in the middle ear, and has potential advantages over traditional methods of sealing CSF leaks.…”

“…Of these, 11 were for patching a CSF leak. Four had their posterior semicircular canal patched after occlusion surgery for intractable benign paroxysmal positional vertigo (BPPV) with excellent long‐term results . One had closure of an old perilymph fistula, following stapes surgery.…”

Oxidative status in patients with benign paroxysmal positional vertigo Small Title: Oxidative stress and BPPV

“…Canalithiasis [3] and cupulolithiasis [4] are the most probable mechanisms underlying BPPV. Although any of the three semicircular canals may be involved, canalithiasis of the posterior semicircular canal is the underlying cause in at least 85% of patients [5] .…”

“…Canalithiasis [3] and cupulolithiasis [4] are the most probable mechanisms underlying BPPV. Although any of the three semicircular canals may be involved, canalithiasis of the posterior semicircular canal is the underlying cause in at least 85% of patients [5] .Oxidative stress, defined as excess production of reactive oxygen species (ROS) that is not counterbalanced by adequate endogenous and exogenous antioxidant defenses, causes cellular dysfunction and is a risk factor for microvascular injury [6] . Several studies have shown an elevation of oxidative stress levels in different pathologies, with higher than control levels of biomarkers such as modified lipids, proteins, and nucleic acids, reductions in antioxidant capacity, and increased ROS production by leukocytes.…”