Bilateral Changes in Foveal Structure in Individuals with Amblyopia

Bruce, Alison; Pacey, Ian E.; Bradbury, John; Scally, Andy J.; Barrett, Brendan T.

doi:10.1016/j.ophtha.2012.07.088

Cited by 47 publications

(73 citation statements)

References 45 publications

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“…Aguirre et al described segmental (superior and nasal) increase in the thickness of central macular [36]. Bruce et al reported a significant increase in macular thickness with reduced foveal pit depth [37]. On the contrary, other studies found no significant evidence of increased macular thickness in patients with amblyopia, and which is in agreement with our results [15-17, 21, 25, 27, 28, 30, 31, 33, 34].…”

Section: Discussionsupporting

confidence: 91%

Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

2015

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The aim of this study was to investigate the presence of increased macular or retinal nerve fiber layer thickness (RNFLT) in amblyopic eyes, find if the increased macular or RNFLT is related to the lack of response in amblyopic eyes, and to explore whether the increased central macular thickness (CMT) in amblyopic eyes is purely related to the hyperopia. This is a prospective descriptive study. CMT and peripapillary RNFLT were measured by spectral-domain optical coherence tomography to evaluate 60 patients with unilateral-treated amblyopia (median age 11.00 year). Patients were divided into two groups: 33 patients in recovered amblyopia group and 27 patients in persistent amblyopia group. The mean CMT in the recovered group was 247.31 (±23.4) versus 246.8 (±32.7) µm (p = 0.95) for the persistent group. The mean peripapillary RNFLT was 99.13 (±12.1) versus 99.9 (±14.9) µm (p = 0.85) for the persistent group. In anisometropic amblyopia, there was no significant difference in CMT and RNFLT in either group. Also there was no relation between the type of refractive error and CMT or RNFLT. There was no significant difference in CMT and RNFLT in amblyopic eyes for both the recovered amblyopia group and the persistent amblyopia group to explain the lack of response in persistent amblyopic eyes. Additionally there was no relation between the type of refractive error and CMT or peripapillary RNFLT.

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Section: Discussionsupporting

confidence: 91%

Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

2015

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“…0.05). The mean age of patients in the anisometropic group (18 females) was 7.9 AE 2.6 years (4-13); of patients in the strabismic group (17 females), 9.0 AE 3.7 (4-15); and of controls (18 females), 8.4 AE 2.6 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14).…”

Section: Resultsmentioning

confidence: 99%

Choroidal thickness of children's eyes with anisometropic and strabismic amblyopia

Aygıt¹,

Yılmaz²,

Özkaya³

et al. 2015

Journal of American Association for Pediatric Ophthalmology and

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“…Park et al[18] found a notable difference between amblyopic and fellow eyes in both the ganglion cell layer and the inner plexiform layer but not in the OS layer. Bruce et al[19] found no difference between amblyopic and fellow eyes but a significant difference between the eyes of amblyopes and controls. These conflicting findings could result from differences in ethnicity, the age of the subjects, severity of amblyopia, or the methods of measuring the thickness of the foveal layers.…”

Section: Introductionmentioning

confidence: 99%

Thickness of retinal layers in the foveas of children with anisometropic amblyopia

Chen

Zhou

et al. 2017

PLoS ONE

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PurposeTo use highly precise spectral-domain optical coherence tomography (SD-OCT) to determine whether there were structural abnormalities in the layers of different regions of the fovea in children with anisometropic amblyopia.MethodsEighteen children (mean age 7.8 years old; range 5–11 years) with unilateral anisometropic amblyopia and 18 age-matched control subjects participated. Foveal thickness was measured with an enhanced depth imaging system, SD-OCT and segmented into layers using custom developed software. The thickness of each layer of the fovea was compared among amblyopic eyes, fellow eyes and control eyes with optical magnification correction for axial length and statistical correction for age and sex.ResultsThe total thickness and each intra-ocular layer of the central fovea were the same for each group. However, the amblyopic eyes were significantly thicker than the normal control eyes in 2 of 4 quadrants of the peripheral retina. Exploring intra-retinal layers in these two quadrants, the nasal nerve fiber layer (NFL) and inferior inner nuclear layer (INL)were significantly thicker in amblyopic eyes than in control eyes (p = 0.01 and 0.012, respectively, by ANCOVA).ConclusionThe SD-OCT data revealed marginal differences in some foveal layers at peripheral locations and indicated that structural differences might exist between individuals with amblyopia and visually normal control subjects. However, the differences were scattered and represented no identifiable pattern. More studies with large samples and precise locations of the retinal layers must be performed to extend the present results.

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Bilateral Changes in Foveal Structure in Individuals with Amblyopia

Cited by 47 publications

References 45 publications

Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

Choroidal thickness of children's eyes with anisometropic and strabismic amblyopia

Thickness of retinal layers in the foveas of children with anisometropic amblyopia

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