Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

Yassin, Sanaa A.; Al-Tamimi, Elham R.; Al-Hassan, Sultan

doi:10.1007/s10792-015-0055-9

Cited by 15 publications

(12 citation statements)

References 40 publications

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“…There was a significant increase in the macular thickness and macular volume in all amblyopic eyes comparing to the other fellow eyes. This corroborated with the previous studies, 9 , 12 while other researchers reported no significant variations in the macular thickness 10 , 30 , 31 or RNFLT 10 , 11 , 30 , 31 in amblyopic eyes.…”

Section: Discussionsupporting

confidence: 92%

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Kasem¹,

Badawi²

2017

OPTH

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PurposeThe purposes of this study were to investigate the changes in macular parameters (thickness, volume) and peripapillary retinal nerve fiber layer (RNFL) thickness (RNFLT) in different cases of amblyopia versus the normal fellow eyes using optical coherence tomography (OCT) and to estimate the relationship of OCT changes with various defined patients’ parameters.DesignThis is a prospective, observational, cross-sectional case series.MethodsThe method involved measuring the peripapillary RNFLT, macular thickness, and macular volume via spectral domain (OCT) in different types of amblyopia and comparing with the other fellow eyes. This study was conducted at the Mansoura Ophthalmic Center.ResultsA total of 64 patients with different types of amblyopia were included. The mean central macular thickness (CMT) was 196.2±50.03 µm in the amblyopic eyes versus 167±12.76 µm in the fellow eyes (P=0.000), the mean average macular thickness was 265.80±12.77 µm in the amblyopic eyes versus 259.10±3.09 µm in the fellow eyes (P=0.000), the mean macular volume was 7.59±0.32 mm3 in the amblyopic eyes versus 7.34±0.071 mm3 in the fellow eyes (P=0.002), and the mean global RNFLT was 97.00±11.60 µm in the amblyopic eyes versus 78.50±13.05 µm in the fellow eyes (P=0.029). There was a discrepancy between the different amblyopic types. Age and the axial length were the only independent variables that statistically significantly correlated with the CMT.ConclusionThe unilateral amblyopic eyes were prone to have a higher CMT and thicker global RNFL compared to those of the sound fellow eyes. Retinal variations between different types of the amblyopia differ from one type to another. The age could be considered as a predictor of the disease worsening and treatment prognosis. Further studies are required to emphasize these results.

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Section: Discussionsupporting

confidence: 92%

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Kasem¹,

Badawi²

2017

OPTH

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“…On the other hand, in the study comparing the axial length and macular thickness in children with anisometropic amblyopia, strabismic amblyopia and healthy children, Kok et al found no difference in the macular thickness of the three groups despite the fact that the axial lengths of the amblyopic and fellow eyes were significantly shorter compared to the control group and stated that the correlation between the axial length and macular thickness in healthy people was not present in the amblyopic and fellow eyes 36 . Yassin et al found no significant differences in the RNFL thicknesses of the persistent and recovered children with amblyopia, stating that the refractive error had no relationship with the macular and RNFL thickness 37 . There are other studies indicating that there is no significant correlation between the RNFL thickness and axial length in amblyopia groups 27,38 .…”

Section: Discussionmentioning

confidence: 97%

Evaluation of Retinal Nerve Fiber Layer Thickness and Macular Thickness in Amblyopic Children

Culha¹,

Arıcı²

2021

Cumhuriyet Medical Journal

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To compare central macular and retinal nerve fiber layer (RNFL) thickness using Spectral Domain Optical Coherence Tomography (SD-OCT) among patients with hyperopic anisometropic, strabismic and mixed amblyopia and healthy controls. Method: This prospective, cross-sectional study included 39 amblyopic children, their fellow eyes and 20 healthy individuals. Central macular and RNFL (superior, nasal, inferior and temporal quadrants and mean RNFL) thicknesses were measured with SD-OCT. Results: Difference was not statistically significant in the central macular thickness when the anisometropic, strabismic and mixed amblyopia groups were compared among themselves, fellow eyes and healthy control group. In the anisometropic amblyopic group, the inferior RNFL and nasal RNFL values were significantly thicker compared to the fellow eyes (p=0.009, p=0.028, respectively). Mean RNFL measurements were significantly thicker in anisometropic and mixed groups in the amblyopic eyes compared to the fellow eyes (p=0.009, p=0.031, respectively). In the temporal quadrant, the RNFL was found to be statistically significantly thinner in the anisometropic and mixed amblyopic groups compared to the fellow eyes (p=0.049, p=0.010, respectively). Conclusions:There was no considerably difference in the central macular thickness among the amblyopia groups, fellow eyes and healthy controls. However, significant changes were found in the mean RNFL and certain quadrants of the RNFL thicknesses in the anisometropic and mixed amblyopic groups.

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“…Unlike the macular vessel system, our data showed unchanged mean macular thickness in unilateral anisometropic amblyopes and in successfully treated anisometropic amblyopic children after adjustment for the AL. Many studies using OCT have examined retinal thickness of amblyopia and evaluated the reversal of difference after treatment with varied methodologies [33][34][35][36][37] . It is reported studies that showed difference in retinal thicknesses tend to show increased thickness associated with amblyopia.…”

Section: Discussionmentioning

confidence: 99%

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Zhang

Xie

Liu

et al. 2021

Sci Rep

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To measure the retinal microvascular density in patients with anisometropic amblyopia using optical coherence tomographic angiography (OCTA) and to evaluate the effects of successful amblyopia treatment on microvasculature in retina. 59 children (5–12 years old) including 22 newly diagnosed unilateral anisometropic amblyopia, 16 recovered unilateral anisometropic amblyopia, and 21 control children were imaged with OCTA using 6 × 6-mm macular scan pattern. Vessel densities of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the overall macular thickness were acquired and compared among the three groups. After adjustment for axial length, the amblyopia group showed lower macular vessel density in the SCP (P = 0.005) and in the DCP (P = 0.004) compared with that of the control group. However, for the recovered amblyopia group, no difference of vessel density was found when compared with the control group in both the SCP (P = 0.548) and the DCP (P = 0.124). No difference of the mean macular thickness was found among three groups (P ≥ 0.15). Children with anisometropic amblyopia have reduced macular vessel density in OCTA, while no difference of macular vessel density was found between the recovered amblyopic and control eyes. Macular thickness showed no difference in anisometropic amblyopia and remained unchanged after amblyopic treatment.

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Macular and retinal nerve fiber thickness in recovered and persistent amblyopia

Cited by 15 publications

References 40 publications

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Changes in macular parameters in different types of amblyopia: optical coherence tomography study

Evaluation of Retinal Nerve Fiber Layer Thickness and Macular Thickness in Amblyopic Children

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

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