Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Zhang, Tengyue; Xie, Shuanglun; Liu, Yangchen; Xue, Caihong; Zhang, Wei

doi:10.1038/s41598-020-79585-4

Cited by 17 publications

(19 citation statements)

References 37 publications

(55 reference statements)

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“…(5,9,10,(14)(15)(16) Regarding macular VD, mixing results have been reported. The studies performed by Sobral et al (10), Zhang et al (17), Yilmaz et al (5) and longgi et al( 9) demonstrated lower macular VD in eyes with amblyopia. However, consistent with our results, Araki et al (14) and Demiyarak et al (18) found no differences regarding VD between amblyopic eyes and healthy controls.…”

Section: Discussionmentioning

confidence: 93%

Optical Coherence Tomography Angiography in Patients with Amblyopia

et al. 2022

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Purpose: To determine the OCTA parameters including foveal avascular zone (FAZ) and vessel density (VD) in the amblyopic eyes compared with the fellow sound eyes and the eyes of the non-amblyopic subjects.Methods: In this case-control study, a total of 62 eyes from unilateral amblyopic children (n= 23) and the age-and sex-matched healthy children (n= 8) were included. The sound eye of the amblyopic children was considered as the internal control (n= 23) and the both eyes of the non-amblyopic children (n= 16) were considered as the external control. All participants underwent image recording with the optical coherence tomography angiography (OCTA) Results: The average age of 23 cases and 8 controls were 9.86±3.12 and 8.5±2.35 years, respectively.Twelve patients (52.2 %) in the case group and 8 subjects (50%) in the control group were female. Macular VD in different regions of super cial and deep capillary plexuses (SCP, DCP) were comparable amongst the case group and both the internal and the external control groups. The average FAZ area was 0.26±0.06 µm 2 in amblyopic eyes that was signi cantly larger than in the fellow eyes (0.21±0.06 µm 2 ; P=0.007) and was comparable to the healthy controls.Conclusion: Lack of signi cant difference of the macular vessel density between the amblyopic and nonamblyopic eyes of the both internal and external controls may be attributed to this fact that the changes of the retinal vascular density cannot be considered as the pathogenesis of amblyopia.

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Section: Discussionmentioning

confidence: 93%

Optical Coherence Tomography Angiography in Patients with Amblyopia

et al. 2022

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“…Some studies report that several retinal microvasculature metrics, including FAZ circularity and VDI, are associated with reduced visual acuity in amblyopic eyes. Zhang and colleauges 9 compared the retinal vessel density in newly diagnosed unilateral anisometropic amblyopia, recovered unilateral anisometropic amblyopia, and control children. They found that children with anisometropic amblyopia showed a reduced macular vessel density compared with controls.…”

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confidence: 99%

The effect of treatment on retinal microvasculature in children with unilateral amblyopia

Xue

et al. 2021

Journal of American Association for Pediatric Ophthalmology and

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To assess whether the abnormal retinal microvasculature in unilateral amblyopia changes following amblyopia treatment. METHODSA total of 70 patients with unilateral amblyopia (4-12 years of age) were initially recruited. Of these, 33 completed follow-up assessments after 6 months of amblyopia treatment. The retinal thickness and microvascular metrics were measured at baseline and after treatment. The interocular differences and longitudinal changes after treatment were analyzed. Partial correlation analysis was performed to explore the associations between best-corrected visual acuity improvements and changes in retinal metrics after treatment. RESULTSThe central retinal thickness, thickness of the ganglion cell-inner plexiform layer, and vessel density index were greater in amblyopic eyes (P \ 0.001, P \ 0.001, P \ 0.001, resp.), whereas the area and circularity of the foveal avascular zone were smaller in amblyopic eyes (P 5 0.014, P \ 0.001, resp.). Better (lower logMAR) visual acuity was associated with greater circularity of the foveal avascular zone in amblyopic eyes (r 5 À0.326; P 5 0.007). The circularity significantly increased after amblyopia treatment in both eyes (P \ 0.001, P 5 0.027), and the changes in circularity in amblyopic eyes were associated with visual acuity improvements (r 5 À0.476; P 5 0.008). CONCLUSIONSPatients with unilateral amblyopia showed interocular differences in retinal microstructure. Foveal avascular zone shape was more irregular in amblyopic eyes and associated with the severity of amblyopia, which tended to improve and become more regular with visual acuity improvements after amblyopia treatment. ( J AAPOS 2021;-:1.e1-7)

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“…One study had the conclusion that amblyopic eye retinal vessel density (RVD) potentially increased after amblyopia treatment in specific regions of the retina ( 19 ). Another study indicated that anisometropic amblyopic eyes with lower macular vessel density could recover to the level of healthy eyes after full correction of the refractive errors and patching ( 20 ). The change of blood flow density in amblyopia before and after treatment is our next research goal.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Optic Nerve in Adults With Amblyopia Using OCTA

Zhang

Yue

et al. 2022

Front. Med.

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ObjectiveThe aim was to quantify and compare papillary and peripapillary vessel density in amblyopic eyes of adults and age-matched controls.MethodsThis cross-sectional study involved 20 eyes from 10 subjects with anisometropic amblyopia and 12 eyes of 6 age- and gender-matched healthy controls. Optical coherence tomography angiography (OCTA) was performed on all participants. SPSS 20 was used for data analysis.ResultsThe mean subject age was 35.7 ± 10.04 years (range 18–47) in the amblyopia group and 34.67 ± 6.92 years (range 23–42) in the control group. The diopter of amblyopia ranges from +3 to +5 ds. The mean inside optic disk capillary vessel density (CVD) was 41.88 ± 6.55% in amblyopic eyes, 49.23 ± 6.55% in fellow eyes, and 50.23 ± 4% in control eyes (p < 0.05). The mean inside optic disk all vessel density (AVD) was 52.97 ± 6.71% in amblyopic eyes, 59.87 ± 4.59% in fellow eyes, and 60.45 ± 2.8% in control eyes (p < 0.05). The amblyopic eye of participants showed a decrease in vessel density in the inside optic disk than in the fellow eyes and healthy subjects.ConclusionOur present study revealed lower vessel density inside the optic disc of adult patients with anisometropic amblyopia. However, further studies are really needed to determine the clinical relevance of this finding.

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Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Cited by 17 publications

References 37 publications

Optical Coherence Tomography Angiography in Patients with Amblyopia

Optical Coherence Tomography Angiography in Patients with Amblyopia

The effect of treatment on retinal microvasculature in children with unilateral amblyopia

Analysis of Optic Nerve in Adults With Amblyopia Using OCTA

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