Bilateral central retinal vein thrombosis in Behçet's disease

Abstract

Behçet's disease is a multisystem disorder affecting the skin, mucous membranes, eye, joints, central nervous system, and blood vessels. One of the known vascular complications of Behçet's disease is venous thrombosis or aneurysm formation. We report, herewith, a patient with Behçet's disease who developed radial artery aneurysm, deep venous thrombosis, and bilateral central retinal vein thrombosis. To our knowledge, this is the first report of bilateral central retinal vein thrombosis in association with Behçet's disease.

Ocular Manifestations of Behçet’s Disease

“…Occlusion of the central retinal artery is extremely rare. Bilateral retinal vein thromboses and bilateral posterior ischemic optic neuropathy have been reported [25,26].…”

Retinal Manifestations of Autoimmune and Inflammatory Disease

“…The most well known sign of BD is the freely mobile hypopyon seen in up to 30% of patients, but this finding is transient and may be missed by the physician. 64,65 The visual morbidity associated with BD is dismal, with 25% to 50% of patients having best-corrected visual acuity <20/200 after 5 years, depending on disease activity. Posterior segment involvement in BD is perhaps the most unsettling manifestation of the disease.…”

Central Retinal Vein Occlusion: Review of Management

“…CRVO has been reported in association with seropositive syphilis (136), ocular syphilis (137), Behçet's disease (138), tuberculosis (44), Crohn's disease (139), Reye's syndrome (140), migraine (20,32), mitral valve prolapse (141,142), cyanotic heart disease (143), and polycystic ovarian syndrome (144). It can occasionally occur after retrobulbar injections (29,31,145), cavernous sinus thrombosis (146), and in association with Moyamoya disease (147), psuedotumor cerebri (24), and acute posterior multifocal placoid pigment epitheliopathy (148).…”