Bilateral Achilles Tendon Ruptures Associated With Ciprofloxacin Use in the Setting of Minimal Change Disease: Case Report and Review of the Literature

Kawtharani, Firas; Masrouha, Karim; Afeiche, Nadim

doi:10.1053/j.jfas.2014.07.005

Cited by 14 publications

(11 citation statements)

References 28 publications

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“…Our results confirm the association between the fluoroquinolones and the AT rupture. The increased risk has been previously reported, and there are multiple case reports about fluoroquinolone antibiotics causing bilateral AT ruptures . Fluoroquinolones have been available in Finland since 1987, and 6 drugs in this class were on the market during our study period.…”

Section: Discussionsupporting

confidence: 55%

“…The increased risk has been previously reported, 10 and there are multiple case reports about fluoroquinolone antibiotics causing bilateral AT ruptures. 22 Fluoroquinolones have been available in Finland since 1987, and 6 drugs in this class were on the market during our study period. Ciproxin, norfloxacin, and ofloxacin were the most commonly used generic molecules.…”

Section: Discussionmentioning

confidence: 93%

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Drug treatments associated with Achilles tendon rupture. A case‐control study involving 1118 Achilles tendon ruptures

Nyyssönen

Lantto

Lüthje

et al. 2018

Scandinavian Med Sci Sports

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The incidence of Achilles tendon (AT) rupture, especially nonsport-related rupture, is increasing, while the reasons for this increase are largely unknown. The association between the AT rupture and the use of various drug treatments was studied. We collected AT rupture patients from the Finnish Hospital Discharge Register. We also acquired information about all the doctor-prescribed drugs they had purchased within 1 year before the rupture. For comparison, we randomly selected age- and sex-matched controls from the Finnish Population Register. There were 1118 AT rupture patients. Several drug groups had a statistically significant association with the AT rupture. Our study confirmed an association between fluoroquinolone antibiotics and AT rupture (OR 2.20, P = 0.005). A statistically significant association of renin-angiotensin II receptor antagonists with tendon rupture (OR 7.59, P = 0.003) was a previously unreported finding. The increasing incidence of AT rupture, especially in middle-aged and elderly patients, might partially be a consequence of the increased use of certain drug treatments. Some associations are probably explained by the symptomatic treatment of the painful tendon before the rupture.

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Section: Discussionsupporting

confidence: 55%

Section: Discussionmentioning

confidence: 93%

Drug treatments associated with Achilles tendon rupture. A case‐control study involving 1118 Achilles tendon ruptures

Nyyssönen

Lantto

Lüthje

et al. 2018

Scandinavian Med Sci Sports

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“…Several risk factors have been identified, including advanced age (>60 years), corticosteroid use, renal failure, female sex and non‐obesity . The most common sites of involvement are the lower limb tendons, more frequently the Achilles tendon . Fluoroquinolones are widely used antibiotics that are indicated in the treatment of wide range of urinary, gastrointestinal, pulmonary, and even bone infections.…”

Section: Discussionmentioning

confidence: 99%

“…Fluoroquinolones are widely used antibiotics that are indicated in the treatment of wide range of urinary, gastrointestinal, pulmonary, and even bone infections. They have excellent gastrointestinal absorption, superior tissue penetration, and broad‐spectrum activity . Although well tolerated and relatively safe, numerous side effects have been reported, including a spectrum of tendinopathies, gastrointestinal disorders, cutaneous eruptions, neurological signs, myalgia, elevated serum transaminases, and arthralgia .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous bilateral patellar tendon rupture: case report and review of fluoroquinolone‐induced tendinopathy

Rosa

Campos

Barros

et al. 2016

Clinical Case Reports

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“…Magnetic resonance imaging may also be used for diagnosis. [7,10,14] The treatment can be performed conservatively, or by surgery, usually in the surgery a primary suture of the lesion is made with satisfactory results, which was applied in the patient's case.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous rupture of the Achilles tendon

Mendes

Sant'Anna²,

Cabral³

et al. 2016

Int Arch Med

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Introduction:The Achilles tendon is the largest and most resistant tendon of the human body and the incidence of spontaneous rupture has increased in recent decades, especially because of the appearance and wide use of quinolones, which use is associated with this pathology.Objective: Case report of case of spontaneous rupture of the Achilles tendon in patients without predisposing risk factors. Method: case report based on the records of the patient and search in literature. Discussion:Spontaneous rupture of the Achilles tendon is more common in men aged between 30 and 50 years old and has an incidence of 1:100,000 in the general population. However, there is a rare entity, the spontaneous rupture of the Achilles tendon (RETA), which it is due to chronic inflammation of the tendon. Conclusion:Spontaneous rupture of the Achilles tendon is a rare entity, but should be suspected in patients who present acute pain condition or maybe worsened chronic pain, particularly when associated with the chronic use of corticosteroids or quinolones, or any of the cited predisposing factors.

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Bilateral Achilles Tendon Ruptures Associated With Ciprofloxacin Use in the Setting of Minimal Change Disease: Case Report and Review of the Literature

Cited by 14 publications

References 28 publications

Drug treatments associated with Achilles tendon rupture. A case‐control study involving 1118 Achilles tendon ruptures

Drug treatments associated with Achilles tendon rupture. A case‐control study involving 1118 Achilles tendon ruptures

Spontaneous bilateral patellar tendon rupture: case report and review of fluoroquinolone‐induced tendinopathy

Spontaneous rupture of the Achilles tendon

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