Bidirectional associations between rheumatoid arthritis and depression: a nationwide longitudinal study

Lu, Ming; Guo, How‐Ran; Lin, Miao Chiu; Livneh, Hanoch; Lai, Ning‐Sheng; Tsai, Tsung-Yu

doi:10.1038/srep20647

Cited by 102 publications

(92 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to our study, 2 previous studies in Taiwan reported an increased incidence of depression in the RA population as compared to controls . Although the prevalence of anxiety disorders is reportedly increased in RA , we could not identify prior studies reporting the incidence of anxiety disorders.…”

Section: Discussionsupporting

confidence: 68%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

117

View full text Add to dashboard Cite

ObjectiveWe estimated the incidence and prevalence of depression, anxiety disorder, bipolar disorder, and schizophrenia in a population‐based cohort with rheumatoid arthritis (RA) as compared to an age‐, sex‐, and geographically matched cohort without RA.MethodsUsing population‐based administrative health data from Manitoba, Canada, we identified persons with incident RA between 1989 and 2012, and a cohort from the general population matched 5:1 on year of birth, sex, and region of residence. We applied validated algorithms for depression, anxiety disorder, bipolar disorder, and schizophrenia to determine the annual incidence of these conditions after the diagnosis of RA, and their lifetime and annual period prevalence. We compared findings between cohorts using negative binomial regression models.ResultsWe identified 10,206 incident cases of RA and 50,960 matched individuals. After adjustment for age, sex, socioeconomic status, region of residence, number of physician visits, and year, the incidence of depression was higher in the RA cohort over the study period (incidence rate ratio [IRR] 1.46 [95% confidence interval (95% CI) 1.35–1.58]), as was the incidence of anxiety disorder (IRR 1.24 [95% CI 1.15–1.34]) and bipolar disorder (IRR 1.21 [95% CI 1.00–1.47]). The incidence of schizophrenia did not differ between groups (IRR 0.96 [95% CI 0.61–1.50]). Incidence rates of psychiatric disorders declined minimally over time. The lifetime and annual period prevalence of depression and anxiety disorder were also higher in the RA than in the matched cohort over the study period.ConclusionThe incidence and prevalence of depression, anxiety disorder, and bipolar disorder are elevated in the RA population as compared to a matched population.

show abstract

Section: Discussionsupporting

confidence: 68%

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Marrie

Hitchon

Walld

et al. 2018

Arthritis Care & Research

117

View full text Add to dashboard Cite

show abstract

“…Chronic pain can independently contribute to the pathogenesis of depression, through elevation of inflammatory cytokines IL‐1β, IL‐6, and TNF‐α . Here, we review the prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD (Tables and ).…”

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

“…As with most complex biologic systems, the relationship between depression and RA is multifactorial with contributory factors involving both the individual characteristics of the patient (including low socioeconomic status; female sex; ethnicity; decreased social support; comorbidities, such as stroke; chronic kidney disease; and cancer) and the biologic state of the disease . The bidirectional association between RA and depression has been implicated, where findings suggests that RA increases the risk of depression, and vice versa …”

Section: Depression In Connective Tissue Diseasesmentioning

confidence: 99%

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Grygiel-Górniak

Limphaibool

Puszczewicz

2019

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Research in the past two decades has revolutionized our understanding of depressive illnesses. Proinflammatory cytokines have become a point of interest in the interconnecting areas of neuropsychiatric and autoimmune diseases. The cytokine hypothesis of depression suggests that pro‐inflammatory cytokines play a primary role in the mediation of the pathophysiological characteristics of major depression, in which an inflammatory process may be induced by external and internal stressors, such as psychological and inflammatory diseases, respectively. The higher prevalence of depression, particularly in patients with chronic autoimmune connective tissue disorders (CTD), suggests that depression may present a dysfunctional adaptation of cytokine‐induced sickness, which could manifest in times of an exacerbated activation of the innate immune system. Inflammation is thought to contribute to the development of clinical depression through its ability to induce sickness behaviors corresponding to the neurovegetative features of depression, through the dysregulation of the hypothalamic–pituitary–adrenal axis, alterations in neurotransmitter synthesis and reuptake, and through its involvement in the neuroprogression pathways. This review explores the complex interrelationships in which inflammatory responses alter neuroendocrine and neuropsychological regulation contributing to depressive symptoms in CTD. The prevalence and characteristics of depression, and its correlation to the levels of inflammatory cytokines and disease activity among different CTD will be reviewed.

show abstract

“…For example, a longitudinal cohort study reported that individuals with depression had 1.3 times [Hazard Ratio (HR) = 1.3, 95%CI: 1.0–1.7] of the risk of developing arthritis as compared to those without depression [160]. Further, a 14-year, population-based cohort study reported significantly higher incidence (HR = 1.65, 95%CI: 1.41–1.77) of RA among individuals with depression as compared to those without depression [161]. …”

Section: Incident Depression and Arthritismentioning

confidence: 99%

Healthcare burden of depression in adults with arthritis

Sambamoorthi

Shah

Zhao

2017

Expert Review of Pharmacoeconomics & Outcomes Research

View full text Add to dashboard Cite

Introduction Arthritis and depression are two of the top disabling conditions. When arthritis and depression exist in the same individual, they can interact with each other negatively and pose a significant healthcare burden on the patients, their families, payers, healthcare systems, and society as a whole. Areas covered The primary objective of this review is to summarize, identify knowledge gaps and discuss the challenges in estimating the healthcare burden of depression among individuals with arthritis. Electronic literature searches were performed on PubMed, Embase, EBSCOhost, Scopus, the Cochrane Library, and Google Scholar to identify relevant studies. Expert Commentary Our review revealed that the prevalence of depression varied depending on the definition of depression, type of arthritis, tools and threshold points used to identify depression, and the country of residence. Depression exacerbated arthritis-related complications as well as pain and was associated with poor health-related quality of life, disability, mortality, and high financial burden. There were significant knowledge gaps in estimates of incident depression rates, depression attributable disability, and healthcare utilization, direct and indirect healthcare costs among individuals with arthritis.

show abstract

Bidirectional associations between rheumatoid arthritis and depression: a nationwide longitudinal study

Cited by 102 publications

References 28 publications

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Increased Burden of Psychiatric Disorders in Rheumatoid Arthritis

Cytokine secretion and the risk of depression development in patients with connective tissue diseases

Healthcare burden of depression in adults with arthritis

Contact Info

Product

Resources

About