Bibliometric and visual analysis of blood-testis barrier research

Abstract

Background: Extensive research on the blood-testis barrier has been undertaken in recent years. However, no systematic bibliometric study has been conducted on this subject. Our research aimed to identify the hotspots and frontiers of blood-testis barrier research and to serve as a guide for future scientific research and decision-making in the field.Methods: Studies on the blood-testis barrier were found in the Web of Science Core Collection. VOSviewer, CiteSpace, and Microsoft Excel were used to conduct the bibliometric and visual analyses.Results: We found 942 blood-testis barrier studies published in English between 1992 and 2022. The number of annual publications and citations increased significantly between 2011 and 2022, notably in the United States. China and the United States, the US Population Council, Endocrinology, and Cheng C. Yan were the most productive countries, institution, journal, and author, respectively. The study keywords indicated that blood-testis barrier research involves a variety of compositional features (tight junctions, cytoskeleton, adherens junctions), cell types (Sertoli cells, germ cells, Leydig cells, stem cells), reproductive toxicity (cadmium, nanoparticles, bisphenol-a), and relevant mechanisms (spermatogenesis, apoptosis, oxidative stress, dynamics, inflammation, immune privilege).Conclusion: The composition and molecular processes of the blood-testis barrier as well as the blood-testis barrier in male infertility patients are the primary research hotspots in this field. In addition, future research will likely focus on treatment and the development of novel medications that target signal pathways in oxidative stress and apoptosis to preserve the blood-testis barrier. Further studies must extend to clinical diagnosis and therapy.

Characteristics of Trauma Patients Admitted to a Tertiary Care University Hospital Emergency Service: One year Cross-sectional Analysis

“…According to another study by Cheau-Feng Lin et al, it was shown that traumatic rib fractures were associated with mortality and had similar results with our study (10).…”

Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis

“…The aggravation of oxidative stress is also detrimental to the maintenance of BTB integrity. 49,53 Excessive oxidative stress in testicular tissue can cause BTB damage in obese male mice, as well as BTB damage in mice exposed to polystyrene microplastics. 54,55 In this study, PS-NP poisoning led to the aggravation of oxidative stress in obese mice, so it is speculated that the aggravation of BTB damage is also due to the exposure of PS-NPs in obese mice.…”

“…However, in our study, exposure to PS‐NPs led to a decrease in testosterone secretion in obese mice, which may indirectly lead to the disruption of BTB integrity. The aggravation of oxidative stress is also detrimental to the maintenance of BTB integrity 49,53 . Excessive oxidative stress in testicular tissue can cause BTB damage in obese male mice, as well as BTB damage in mice exposed to polystyrene microplastics 54,55 .…”

Covid-19 Ve Otopsi̇ Özeli̇nde Bi̇r Bi̇bli̇ometri̇k Çalişma

“…Bibliometri; yayınlanan bilimsel makale, kitap ve diğer yayınların sayısal analizler ve istatistikler yardımıyla disiplinlerin ilerlemesini değerlendirmek ve izlemek için bir yöntem olarak tanımlanır (9). Bibliometrik analiz ise; belirli bir alanda belirli bir dönemde ve belirli bir bölgede kişiler ya da kurumlar tarafından üretilmiş yayınların ve bu yayınlar arasındaki ilişkilerin kalitatif ve kantitatif analizidir (10,11).…”