2023
DOI: 10.1002/tox.23923
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Polystyrene nanoplastics aggravate reproductive system damage in obese male mice by perturbation of the testis redox homeostasis

Abstract: The potential impact of the combination of a high‐fat diet (HFD) and polystyrene nanoplastics (PS‐NPs) on fertility cannot be ignored, especially when the fertility rate is declining. However, it has not attracted considerable attention. In this study, an obese mouse model was established using an HFD, and the reproductive function of male mice was evaluated after intragastric administration of 100 μL of a 10 mg/mL PS‐NP suspension for 4 weeks. By determining the morphology and vitality of sperm and related in… Show more

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Cited by 4 publications
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“…Hence, this disturbance in the equilibrium of redox homeostasis can carry substantial implications for testicular function and overall male reproductive health, a trend corroborated by previous studies of various nanomaterials. Notably, research by refs has consistently reported similar outcomes, emphasizing the relevance and broad applicability of these findings in the context of nanomaterial-induced effects on testicular physiology and male reproductive well-being.…”
Section: Resultssupporting
confidence: 85%
“…Hence, this disturbance in the equilibrium of redox homeostasis can carry substantial implications for testicular function and overall male reproductive health, a trend corroborated by previous studies of various nanomaterials. Notably, research by refs has consistently reported similar outcomes, emphasizing the relevance and broad applicability of these findings in the context of nanomaterial-induced effects on testicular physiology and male reproductive well-being.…”
Section: Resultssupporting
confidence: 85%