BF₂-Oxasmaragdyrin Nanoparticles: A Non-toxic, Photostable, Enhanced Non-radiative Decay-Assisted Efficient Photothermal Cancer Theragnostic Agent

Abstract

Photothermal therapy (PTT), a simple and minimally invasive procedure, is an attractive option for cancer therapy. To date, inorganic agents have been widely employed as photothermal agents; however, organic molecules may provide a solution to rapid metabolic/in vivo clearance. Herein, we prepared lipid (S 75)-stabilized meso-tritolyl-BF2-oxasmaragdyrin nanoparticles (TBSNPs) using thin-film hydration and homogenization. Assessment of the physicochemical properties of the TBSNPs reveals the formation of particles of size <12 nm stabilized within the lipid matrix. The TBSNPs exhibit near infrared fluorescence (NIRF) being accompanied by an increase in non-radiative decay, leading to excellent photothermal properties. In vitro studies demonstrate excellent biocompatibility, hemocompatibility, cellular internalization, and photothermal efficacy (p = 0.0004). Extensive in vivo assessment of TBSNPs also highlights the non-toxic nature of the material and passive tumor homing. The strong NIRF exhibited by the material is exploited for whole-body imaging in the rodent model. The novel material also shows excellent photothermal efficacy (p = 0.0002) in a 4T1 xenograft mice model. The organic nature of the material coupled with its small size and strong NIRF provides an advantage for bio-elimination and potential clinical image-guided therapy over the inorganic counterparts.

Sheet-like 2D Manganese(IV) Complex with High Photothermal Conversion Efficiency

“…These spectral features are ascribed to metal-to-ligand charge transfer transitions involving the high-valent manganese ion. We note that the extinction coefficients of Mn-HDCL are considerably higher than those of most photothermal materials. − …”

Enhanced photothermal heating and combination therapy of NIR dye via conversion to self-assembled ionic nanomaterials

“…For example, bovine serum albumin NPs loaded with cyanine dye showed only 29% 41 light to heat conversion efficiency and amphiphilic polypeptide-based NPs encapsulated with NIR absorbing cyanine derivative exhibited slightly less (41%) efficiency as compared to the combination INMs. 42 The high efficiency of INMs is attributed to the improved k non-rad , greater molar absorptivity at 808 nm and high temperature change (when irradiated with laser) of [P 66614 ][IR783] INMs. 43 NaIR820 and [P 66614 ][IR820] INMs showed similar values of heat efficiency (Table 2).…”

A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery

“…In addition, with a large amount of the HEPES buffer solution added during the hydration process, the formed LPNs/miRNA were self-assembled into stable particles with the solvent-switching effect of chloroform/water, adequately. 36 The suitable hydration volume and hydration time could provide self-assembly surroundings. On the basis of the smaller particle size and better uniformity, 1 mL of HEPES volume and 0.5 h hydration time were chosen for LPNs fabrication.…”