A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery

Zhao, Yipu; Ye, Weiliang; Wang, Xue; Huai, Ying; Huang, Qinghui; Chu, Xiaohua; Deng, Xudong; Qian, Airong

doi:10.1039/d2bm01454h

Cited by 13 publications

(7 citation statements)

References 49 publications

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Section: Characterization Of Gene-loaded Hydrogelsmentioning

confidence: 99%

“…Therefore, researchers encapsulated therapeutic genes in liposomes and polymeric NP vectors and loaded them onto a hydrogel to improve their transfection efficiency (Fig. 5 C) [ 156 ]. Hydrogel microspheres (MSs) have attracted considerable attention in the field of minimally invasive tissue repair, and amino acid coupling is a popular method for enhancing gene transfection efficiency [ 160 ].…”

Section: Characterization Of Gene-loaded Hydrogelsmentioning

confidence: 99%

“…However, miRNA targeting the target site is limited owing to skin barrier restrictions (such as stratum corneum obstruction) or insufficient resistance of miR-218 to enzymatic degradation. Zhao et al [ 156 ] used HA microneedles to enhance the permeability of the stratum corneum and then used lipid polymer hybrid nanoparticles (LPNs) as the delivery vehicle of miR-218 to avoid enzymatic degradation, which efficiently promoted the diffusion of LPNs/miR-218 in the dermal region and maximized the utilization of miR-218 (Fig. 12 B).…”

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

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Developing hydrogels for gene therapy and tissue engineering

Su,

Lin,

Huang

et al. 2024

J Nanobiotechnol

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Hydrogels are a class of highly absorbent and easily modified polymer materials suitable for use as slow-release carriers for drugs. Gene therapy is highly specific and can overcome the limitations of traditional tissue engineering techniques and has significant advantages in tissue repair. However, therapeutic genes are often affected by cellular barriers and enzyme sensitivity, and carrier loading of therapeutic genes is essential. Therapeutic gene hydrogels can well overcome these difficulties. Moreover, gene-therapeutic hydrogels have made considerable progress. This review summarizes the recent research on carrier gene hydrogels for the treatment of tissue damage through a summary of the most current research frontiers. We initially introduce the classification of hydrogels and their cross-linking methods, followed by a detailed overview of the types and modifications of therapeutic genes, a detailed discussion on the loading of therapeutic genes in hydrogels and their characterization features, a summary of the design of hydrogels for therapeutic gene release, and an overview of their applications in tissue engineering. Finally, we provide comments and look forward to the shortcomings and future directions of hydrogels for gene therapy. We hope that this article will provide researchers in related fields with more comprehensive and systematic strategies for tissue engineering repair and further promote the development of the field of hydrogels for gene therapy. Graphical abstract

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Section: Characterization Of Gene-loaded Hydrogelsmentioning

confidence: 99%

Section: Characterization Of Gene-loaded Hydrogelsmentioning

confidence: 99%

Section: Tissue Engineering Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Developing hydrogels for gene therapy and tissue engineering

Su,

Lin,

Huang

et al. 2024

J Nanobiotechnol

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“…The study established the combination device as a novel and effective approach for localized transdermal miRNA delivery to promote hair regrowth. [ 82 ]…”

Section: Lipid Nanocarriersmentioning

confidence: 99%

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Albakr,

Du,

Zhang

et al. 2024

Advanced NanoBiomed Research

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New advancements in nanocarrier technologies are revolutionizing the delivery of drugs through the skin, allowing for precise treatment with better absorption, stability, and bioavailability. This review investigates lipid and inorganic nanocarriers like liposomes, ethosomes, and inorganic nanoparticles and assesses their potential for delivering drugs through the skin. It emphasizes the mechanisms that enable controlled release and deeper skin penetration, which are crucial for ensuring effectiveness in clinical applications. The review synthesizes existing research, acknowledging that only few nanocarriers are successfully deployed in clinical settings. By offering a comprehensive overview, it sheds light on the progress and future obstacles to using nanocarriers for drug delivery through the skin.

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“…Zhao et al 203 noticed that microRNA-218 (miR-218) promotes hair regeneration. The resistance of enzymatic degradation was the major strategy for the development of lipid polymer hybrid nanoparticles (LPNs) delivered by hyaluronic acid−based microneedles.…”

Section: Microneedlesmentioning

confidence: 99%

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

Wu,

2023

Mol. Pharmaceutics

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Over 50% of the global population suffers from hair loss. The mixed results in the treatment of hair loss reveal the limitations of conventional commercial topical drugs. One the one hand, the definite pathogenesis of hair loss is still an enigma. On the other hand, targeted drug carriers ensure the drug therapeutic effect and low side effects. This review highlights the organization and overview of nine crucial signaling pathways associated with hair loss, as well as the development of nanobased topical delivery systems loading the clinical drugs, which will fuel emerging hair loss treatment strategies.

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A lipid–polymer hybrid nanoparticle (LPN)-loaded dissolving microneedle patch for promoting hair regrowth by transdermal miR-218 delivery

Abstract: Alopecia is the most common multifactorial hair loss disorder, affecting almost 50% population and even having serious psychological impact on the patients. miR-218 has therapeutic potential for alopecia since it...

Cited by 13 publications

References 49 publications

Developing hydrogels for gene therapy and tissue engineering

Developing hydrogels for gene therapy and tissue engineering

Progress in Lipid and Inorganic Nanocarriers for Enhanced Skin Drug Delivery

Nanodrug Delivery Strategies to Signaling Pathways in Alopecia

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