Enhanced photothermal heating and combination therapy of NIR dye via conversion to self-assembled ionic nanomaterials

Abstract

Combination nanodrugs are promising therapeutic agents for cancer treatment. However, they often require the use of complex nanovehicles for transportation into the tumor site. Herein, a new class of carrier-free...

Advances of ionic liquid-based nanohybrids for biomedical applications

“…Another chemo-PTT combination drug [P 66614 ][IR783] was prepared in a similar way. 171,172 Under ultrasonic treatment, the concentrated stock solution of IMs ([P 66614 ][IR820] and [P 66614 ][IR783]) in ethanol was dropped into the vial containing water to obtain new ionic nanomaterials (INM). After laser irradiation (808 nm, 1 W cm −2 ), [P 66614 ][IR783] INMs showed better photothermal conversion efficiency than the parent dye.…”

Development of novel polymeric nanoagents and their potential in cancer diagnosis and therapy runing title: Polymeric nanoagents for cancer theranostics

“…In recent, polymeric nanoagents-guided chemotherapy, nucleic acid therapy, PDT and PTT, emerge as remarkable approaches for achieving cancer treatment (Wang et al, 2022c;Yu et al, 2022) (Table 2). These advanced strategies selectively target into cancer tissues with minimal invasion into healthy tissues as well as prominently enhance the therapeutic efficacy (Liu et al, 2022b;Macchi et al, 2022).…”

“…Besides chemotherapy, PDT-produced ROS and PTTgenerated heating specifically trigger phototoxic death of cancer cells with the assistance of optical nanoagents (Liu et al, 2022b;Macchi et al, 2022). Fullerene (C60) possess remarkable photophysical properties, thereby it can be used as a potentially strong photoactivatable agent for PDT via triggering ROS production (Gunduz et al, 2022).…”

Quercetin@Gd3+ doped Prussian blue nanocubes induce the pyroptotic death of MDA-MB-231 cells: combinational targeted multimodal therapy, dual modal MRI, intuitive modelling of r1–r2 relaxivities

“…Herein, the synergistic effects of combinational therapies have gained attention due to their inherent non-invasiveness, lower side effects, and high spatiotemporal accuracy. 15 Among different traditional nanomaterials, e.g. noble metal, carbon etc.…”