Beyond structural models for the mode of action: How natural antimicrobial peptides affect lipid transport

Functional and Bioactive Properties of Peptides Derived from Marine Side Streams

“…The activity of antimicrobial peptides can be understood through the use of different models, including the toroidal pore model, barrel stave model, Shai Matsuzaki Huang model and carpet model. Many other hypothetical and tentative models have been used to understand the action of antimicrobial peptides in order to show how they can break cell membranes, involving dynamic simulations, molecular mean-field theory and coarse-grained simulations [70].…”

Efficacy of Cathelicidin-Mimetic Antimicrobial Peptoids against Staphylococcus aureus

“…α-helical AMPs have been studied extensively and this important group includes well-known AMPs such as the magainins and cathelicidins ( 9 ). These AMPs disrupt and pass through the cell membrane, either by pore formation or changes to lipid packing and dynamics, as seen by some magainins, protegrins and LL-37, which is the only human cathelicidin peptide ( 11 – 13 ). LL-37 is involved in numerous cellular functions, including defense against a broad range of microbial infections, and immunomodulation ( 14 ).…”

Collective dynamics in lipid membranes containing transmembrane peptides

“…For example, recent work had also started to reveal that antimicrobial peptides can significantly alter lipid exchange and flip-flop kinetics at lower concentrations than needed to form oligomeric pores and without causing significant changes in the overall membrane structure. [83][84][85][86] Similarly, the sub-micromolar (o10 À6 mol L À1 ) Ala concentrations studied here have been shown to kill several strains of bacteria despite not affecting the overall membrane structure. 87,88 The present studies suggest that low antimicrobial peptide concentrations can significantly impact the collective membrane dynamics in model membranes and thus the corresponding elastic properties that influence membranerelated cell processes such as cell budding or endocytosis.…”