Beurteilung der biologischen Verträglichkeit von PMMA-, heparinmodifizierten PMMA- und Hydrogel-Intraokularlinsen mit Hilfe der Spiegelmikroskopie

Abstract

In order to find a difference in the biocompatibility of different IOL-materials we examined the lens-surface of poly(methylmetacrylate)-(PMMA-), heparin surface-modified PMMA-(HSM-PMMA-) and hydrogel-IOLs in a prospective study by specular microscopy. Documentation consisted of cellular reaction, precipitates on the lens-surface and irregularities of the IOL-material. Early postoperative on HSM-PMMA and hydrogel-IOLs there were fewer fibroblast-like cells as compared to PMMA-IOLs. In the later postoperative period foreign body giant cells were seen on PMMA-IOLs in 26.6%, on HSM-PMMA and hydrogel-IOLs in less than 10% of the cases. In cases with increased postoperative inflammation or contact between uveal tissue and lens-surface we found more cells and in a higher percentage. Concerning precipitates on the surface and material irregularities we also found lens-specific differences. Clinical results were satisfactory for all lens-types.

Inflammatory Response to Polymeric Materials

“…The reference material is poly(methyl methacrylate) (PMMA), which has been clinically used for years with rather satisfactory results after Ridley observed the good tolerance of PMMA debris by the eyes of wounded airmen of World War II. Several authors have compared other materials, e.g., silicone (Skorpik et al, 1993;Wenzel et al, 1993) and/or Acrysof or hydrogel (Amon and Menapace, 1992;Hollick et al, 1998), with it. The inflammatory reaction was mild and similar for silicone and PMMA.…”

Interaktion von Silikonöl mit verschiedenen Intraokularlinsen - Eine licht- und rasterelektronenmikroskopische Untersuchung

“…1 Universitats-Augenklinik Mainz (Direktor: Prof. Dr. N. Pfeiffer) 2 Universitats-Augenklinik Giefien (Direktor: Prof. Dr. med. K.W.…”