Interaktion von Silikonöl mit verschiedenen Intraokularlinsen - Eine licht- und rasterelektronenmikroskopische Untersuchung

Dick, Burkhard; Stoffelns, Bernhard; Pavlovic, Sima; Schwenn, Oliver; Pfeiffer, Norbert

doi:10.1055/s-2008-1035121

Cited by 23 publications

(14 citation statements)

References 9 publications

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“…Dick et al [21]had studied the interaction between silicone oil and various IOLs under light and scanning electron microscopy, using different IOL materials (PMMA, silicone, hydrogel) and surface modifications (CeeOn 809P and 809C, Soflex LI41U, Alcon AcrySof M60BM, Allergan SI-30NB, SI-40NB, Chiron adatomed 90D, C10 and C31UB, MemoryLens U940A, Corneal ISHEMA 66, Storz H60M) that were stored in vitro together with silicone oil (1,000 cs). They reported that silicone oil strongly adhered to holes and to the IOL surface, especially in the case of silicone and PMMA IOLs.…”

Section: Discussionmentioning

confidence: 99%

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Interaction of Intraocular Lenses with Various Concentrations of Silicone Oil: An Experimental Study

Öner

Saatci²,

Sarıoğlu³

et al. 2003

Ophthalmologica

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The aim of this study was to evaluate the interaction between various widely used intraocular lenses (IOLs) and silicone oils of different viscosities. Four groups of IOLs, including monoblock foldable hydrophilic acrylic IOLs (Morcher, type 92s); monoblock hydrophobic acrylic IOLs (Acrysof^®-SA60AT, Alcon); single-piece rigid polymethylmethacrylate (PMMA) IOLs (Intraocular Optical International-IOI-65130) and a three-piece foldable silicone optic IOL (CeeOn^® Edge 911A, Pharmacia UpJohn) were analyzed in vitro to determine the percentage adherence 1,000-centistoke, 1,300-centistoke or 5,000-centistokes silicone oil on the IOL optic. For each IOL type, there was no statistically significant difference in the mean silicone oil coverage (MSC) of the IOL optics for the different viscosities of silicone oil. Silicone IOLs had the highest MSC percentage (79.9%) whereas hydrophilic acrylic IOLs were the least silicone-covered IOLs (7.8%) compared to the other IOL types tested in this study. It is not the concentration of silicone oil that affects silicone oil coverage. When performing small-incision cataract surgery in patients who may require silicone oil injection, foldable hydrophilic acrylic or hydrophobic acrylic lenses should be preferred over standard foldable silicone lenses.

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Section: Discussionmentioning

confidence: 99%

“…In several clinical and experimental studies, the interaction of silicone oil with various IOLs has been investigated [19, 20, 21, 22, 23]. In most of these studies, one type of silicone oil was used.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Intraocular Lenses with Various Concentrations of Silicone Oil: An Experimental Study

Öner

Saatci²,

Sarıoğlu³

et al. 2003

Ophthalmologica

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“…Using a standardized preparation sequence [7], the number of vacuoles (glistenings) in the optical section was quantified using light microscopy. A third IOL was removed from its sterile packing, hydrated with BSS, and its optical surface was examined using light and scanning electron microscopy.…”

Section: Controlsmentioning

confidence: 99%

“…Furthermore, he found clear evidence that these changes were most notable and severest in patients with diabetes mellitus. The results of previous studies suggest a possible relationship between the incidence of these vacuoles and the composition of the aqueous humor [7,8]. Dick et al [7] observed an increase in intralental microvacuoles in Acrysof IOLs with the addition of silicone oil to the aqueous humor.…”

mentioning

confidence: 96%

“…The results of previous studies suggest a possible relationship between the incidence of these vacuoles and the composition of the aqueous humor [7,8]. Dick et al [7] observed an increase in intralental microvacuoles in Acrysof IOLs with the addition of silicone oil to the aqueous humor. The study by Lucke et al [8] provides clinical evidence for a positive correlation between alteration of the blood-retina or the blood-aqueous barrier and the degree of intensity of the glistenings in Acrysof IOLs.…”

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confidence: 96%

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Vacuoles in the Acrysof<sup>TM</sup> Intraocular Lens as Factor of the Presence of Serum in Aqueous Humor

et al. 2001

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Objective: Acrysof™ (Alcon) foldable lenses (IOLs) have been shown to be highly biocompatible and exhibit a low incidence of posterior capsular opacification. However, minute vacuoles or ‘glistenings’ have been observed in some Acrysof IOLs. The clinical relevance of vacuole formation is presently unclear. To help clarify the influence of factors present under in vivo conditions on vacuole formation, the present experimental study examines the influence of aqueous humor components on the occurrence of vacuoles in Acrysof IOLs. Methods: A total of 12 sterile Acrysof IOLs (Alcon, MA60BM) were incubated at body temperature (37°C) for 3 or 6 months in anterior-chamber aqueous humor with or without human serum. The center portion was cut from two unconditioned, unhydrated, sterile control IOLs and the 12 conditioned IOLs and examined using light microscopy for vacuole formation. A third unconditioned, hydrated control IOL was examined using light and scanning electron microscopy. Measures: The incidence of vacuoles was quantified by two independent investigators using light microscopy. After hydration with balanced salt solution, the surface quality of a control IOL was examined using scanning electron microscopy. Results: The control IOLs exhibited no or very few vacuoles. Scanning electron microscopy revealed that the control IOLs had normal surface texture without any surface vacuoles. IOLs that had been conditioned in aqueous humor without serum exhibited no great increase in the number of vacuoles, whereas IOLs conditioned in aqueous humor with serum exhibited a greater number of vacuoles that increased over time. Conclusions: The number of vacuoles increases with incubation time in aqueous humor containing serum. The addition of serum increased the proportion of lipids and proteins in the solution, which also occurs with a breakdown in the blood-aqueous barrier. The results of the present study point to a physiological factor that may lead to vacuole formation in IOLs and may aid clinicians in identifying risk factors involved in the formation of vacuoles.

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Klinische und ultraschallbiomikroskopische Untersuchung der Silikonöladhäsion auf Intraokularlinsen

Schmitz¹,

Dick²,

Jahn³

et al. 1998

11. Kongreß Der Deutschsprachigen Gesellschaft Für Intraokularlinsen-Implantation Und Refraktive Chirurgie

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Interaktion von Silikonöl mit verschiedenen Intraokularlinsen - Eine licht- und rasterelektronenmikroskopische Untersuchung

Cited by 23 publications

References 9 publications

Interaction of Intraocular Lenses with Various Concentrations of Silicone Oil: An Experimental Study

Interaction of Intraocular Lenses with Various Concentrations of Silicone Oil: An Experimental Study

Vacuoles in the Acrysof<sup>TM</sup> Intraocular Lens as Factor of the Presence of Serum in Aqueous Humor

Klinische und ultraschallbiomikroskopische Untersuchung der Silikonöladhäsion auf Intraokularlinsen

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