Betulinic acid attenuates lung injury by modulation of inflammatory cytokine response in experimentally-induced polymicrobial sepsis in mice

Lingaraju, Madhu Cholenahalli; Pathak, N.N.; Begum, Jubeda; Balaganur, Venkanna; Bhat, Rafia Ahmad; Ramachandra, Harish Darasaguppe; Ayanur, Anjaneya; Ram, Mahendra; Singh, Vishal; Kumar, Dhirendra; Kumar, Dinesh; Tandan, Surendra K.

doi:10.1016/j.cyto.2014.09.004

Cited by 40 publications

(26 citation statements)

References 42 publications

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“…We found that MPO activity, one of the markers of neutrophil accumulation in lung tissue, is elevated in CLP group. In some earlier studies, MPO was found to be increased in lungs in CLP‐induced sepsis (Lingaraju et al ., ; Wang et al ., ). Another observation in this study was that TMR treatment attenuated this elevation and thus prevents the severity of lung injury.…”

Section: Discussionmentioning

confidence: 97%

Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

Latief

Anand

Lingaraju

et al. 2015

Phytotherapy Research

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The Eugenia jambolana is used in folklore medicine. Leaves of E. jambolana contain flavonoids as their active constituents which possess in vitro antiinflammatory, antioxidant and the antimicrobial activity. The aim of the present study was to investigate the antiinflammatory and antioxidant effects of a flavonoid glucoside, trimeric myricetin rhamnoside (TMR) isolated from leaves of E. jambolana. TMR was studied for antiinflammatory activity in carrageenan-induced hind paw oedema and antioxidant activity in lung by caecal ligation and puncture (CLP)-induced sepsis in mice. Results of the present study indicated that TMR significantly attenuated the oedema, myeloperoxidase (MPO), cytokines and prostaglandin levels in the paw after 5 h of carrageenan injection as compared to vehicle control. It also reduced the lung MPO, lipid peroxides, and serum nitrite plus nitrate levels and increased lung reduced glutathione levels 20 h of CLP as compared to vehicle control. Thus the results of this study concluded that the TMR appears to have potential benefits in diseases that are mediated by both inflammation and oxidative stress and support the pharmacological basis of use of E. jambolana plant as traditional herbal medicine for the treatment of inflammatory diseases.

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Section: Discussionmentioning

confidence: 97%

Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

Latief

Anand

Lingaraju

et al. 2015

Phytotherapy Research

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“…Although the beneficial effects of XBJ have been widely investigated, the actual molecular mechanisms of XBJ are still unclear. Therefore, we used the animal model of caecal ligation and puncture (CLP), because CLP is the most widely used model and more closely mimics the clinical conditions of sepsis-induced lung injury [ 20 , 21 ]. Moreover, the present study is designed to determine whether XBJ can suppress the development of sepsis-induced lung injury through inhibiting the inflammatory signaling pathway mediated by HMGB1 and RAGE, which plays an essential role in the pathological process of lung injury previously described.…”

Section: Introductionmentioning

confidence: 99%

Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

Wang

Tong

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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Xuebijing (XBJ) injection, a traditional Chinese medicine, has been reported as a promising approach in the treatment of sepsis in China. However, its actual molecular mechanisms in sepsis-induced lung injury are yet unknown. Therefore, this study aimed to investigate the beneficial effects of XBJ on inflammation and the underlying mechanisms in a model of caecal ligation and puncture-(CLP-) induced lung injury. The mice were divided into CLP group, CLP+XBJ group (XBJ, 4 mL/kg per 12 hours), and sham group. The molecular and histological examinations were performed on the lung, serum, and bronchoalveolar lavage (BAL) fluid samples of mice at the points of 6, 24, and 48 hours after CLP. The results show that XBJ reduces morphological destruction and neutrophil infiltration in the alveolar space and lung wet/dry weight ratio, which improves mortality of CLP-induced lung injury. Meanwhile, XBJ treatment downregulates high mobility group box protein 1 (HMGB1) and the receptor for advanced glycation end products (RAGE) expression, as well as neutrophil counts, production of IL-1β, IL-6, and TNF-α in the BAL fluids. In conclusion, these results indicate that XBJ may reduce the mortality through inhibiting proinflammatory cytokines secretion mediated by HMGB1/RAGE axis.

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“…Similarly, the induction of NF-κB activation by carcinogens has been shown to be suppressed by 2 through inhibition of IκBα kinase and p65 phosphorylation as well as abrogation of cyclooxygenase-2 and matrix metalloprotease-9 [22]. The suppressive effect of 2 against pro-inflammatory prostaglandin E 2 production in vitro [23] and neutrophil recruitment and inflammatory mediator expression in lipopolysaccharide-induced lung inflammation in vivo [20,24] were also demonstrated. Interestingly, the expression of the cytokines (e.g.…”

Section: Resultsmentioning

confidence: 82%

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

et al. 2015

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Betulinic acid attenuates lung injury by modulation of inflammatory cytokine response in experimentally-induced polymicrobial sepsis in mice

Cited by 40 publications

References 42 publications

Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

Xuebijing Ameliorates Sepsis-Induced Lung Injury by Downregulating HMGB1 and RAGE Expressions in Mice

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

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