Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

Armah, Francis Ackah; Annan, Kofi; Mensah, Abraham Yeboah; Amponsah, Isaac Kingsley; Tocher, Derek A.; Habtemariam, Solomon

doi:10.1016/j.fitote.2015.06.001

Cited by 20 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Metabolites with the same fragment may contain the same pharmacological groups in their structures and act at the same targets with the same effects. For example, according to the literature, among the eighteen metabolites with fragment 3, eight metabolites ( M70 [58], M73 [59], M74 [59], M75 [60], M80 [61], M83 [59], M104 [58] and M105 [62]) exhibit antioxidant activity and five metabolites ( M70 [63], M75 [64], M80 [63], M104 [65] and M105 [66]) exhibit anti-inflammatory effects. Therefore, we speculated that other metabolites with the same fragment 3 may also exhibit the same bioactivities because they may act on the same individual targets.…”

Section: Resultsmentioning

confidence: 99%

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Yang

et al. 2016

Molecules

View full text Add to dashboard Cite

Abstract:Taxifolin is a ubiquitous bioactive constituent of foods and herbs. To thoroughly explore its metabolism in vivo, an HPLC-ESI-IT-TOF-MS n method combined with specific metabolite detection strategy was used to detect and identify the metabolites of taxifolin in rats. Of the 191 metabolites tentatively identified, 154 were new metabolites, 69 were new compounds and 32 were dimers. This is the first report of the in vivo biotransformation of a single compound into more than 100 metabolites. Furthermore, acetylamination and pyroglutamic acid conjugation were identified as new metabolic reactions. Seventeen metabolites were found to have various taxifolin-related bioactivities. The potential targets of taxifolin and 63 metabolites were predicted using PharmMapper, with results showing that more than 60 metabolites have the same five targets. Metabolites with the same fragment pattern may have the same pharmacophore. Thus these metabolites may exert the same pharmacological effects as taxifolin through an additive effect on the same drug targets. This observation indicates that taxifolin is bioactive not only in the parent form, but also through its metabolites. These findings enhance understanding of the metabolism and effective forms of taxifolin and may provide further insight of the beneficial effects of taxifolin and its derivatives.

show abstract

Section: Resultsmentioning

confidence: 99%

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Yang

et al. 2016

Molecules

View full text Add to dashboard Cite

show abstract

“…BA from Erythrophleum ivorense (A Chev.) was applied in chicken injected with carrageenan in the right footpad to evaluate its anti-inflammatory properties [ 79 ]. BA exhibited a significant anti-inflammatory effect by reducing carrageenan-induced edema [ 79 ].…”

Section: Biological Activitiesmentioning

confidence: 99%

A Review on Preparation of Betulinic Acid and Its Biological Activities

Lou

Zhang

et al. 2021

Molecules

View full text Add to dashboard Cite

Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch, eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological properties, such as anti-inflammatory, antibacterial, antiviral, antidiabetic, antimalarial, anti-HIV and antitumor effects. Among them, the antitumor activity of betulinic acid has been extensively studied. However, obtaining betulinic acid from natural resources can no longer meet the needs of medicine and nutrition, so methods such as chemical synthesis and microbial biotransformation have also been used to prepare betulinic acid. At the same time, with the development of synthetic biology and genetic engineering, and the elucidation of the biosynthetic pathways of terpenoid, the biosynthesis of betulinic acid has also been extensively researched. This article reviews the preparation of betulinic acid and its pharmacological activities, in order to provide a reference for the research and utilization of betulinic acid.

show abstract

“…The 70% alcoholic root extract suppressed foot pad oedema in a time and dose-dependent manner. Three constituents, a casein type diterpene namely erythroivorensin A, betulininc acid and the flavonoid, eriodictyol isolated from the roots exhibited significant reduction of carrageenaninduced foot pad oedema better than the standard drug diclofenac [46].…”

Section: Erythrophleum Ivorense (A Chev) (Fabaceae)mentioning

confidence: 98%

Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

Asante-Kwatia¹,

Mensah²,

Baidoo³

2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

View full text Add to dashboard Cite

Medicinal plants continue to be used in various cultures of the world as safe therapeutic agents against various issues including pain and inflammation which underlie almost every disease process. In Ghanaian traditional medicine, various parts of several plants have been used alone or in combination of therapies for the treatment of various painful inflammatory conditions. In this chapter, the anti-inflammatory and analgesic (antinociceptive) properties of selected medicinal plants from Ghana are reviewed. Evidence of pharmacological activities of crude extracts and fractions in in-vitro and in-vivo models, bioactive anti-inflammatory and antinociceptive compounds isolated as well as possible mechanisms of anti-inflammatory and antinociceptive action are discussed.

show abstract

Erythroivorensin: A novel anti-inflammatory diterpene from the root-bark of Erythrophleum ivorense (A Chev.)

Cited by 20 publications

References 33 publications

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

Detection of 191 Taxifolin Metabolites and Their Distribution in Rats Using HPLC-ESI-IT-TOF-MSn

A Review on Preparation of Betulinic Acid and Its Biological Activities

Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

Contact Info

Product

Resources

About