Effect of Trimeric Myricetin Rhamnoside (TMR) in Carrageenan‐induced Inflammation and Caecal Ligation and Puncture‐induced Lung Oxidative Stress in Mice

Abstract

The Eugenia jambolana is used in folklore medicine. Leaves of E. jambolana contain flavonoids as their active constituents which possess in vitro antiinflammatory, antioxidant and the antimicrobial activity. The aim of the present study was to investigate the antiinflammatory and antioxidant effects of a flavonoid glucoside, trimeric myricetin rhamnoside (TMR) isolated from leaves of E. jambolana. TMR was studied for antiinflammatory activity in carrageenan-induced hind paw oedema and antioxidant activity in lung by caecal ligation and puncture (CLP)-induced sepsis in mice. Results of the present study indicated that TMR significantly attenuated the oedema, myeloperoxidase (MPO), cytokines and prostaglandin levels in the paw after 5 h of carrageenan injection as compared to vehicle control. It also reduced the lung MPO, lipid peroxides, and serum nitrite plus nitrate levels and increased lung reduced glutathione levels 20 h of CLP as compared to vehicle control. Thus the results of this study concluded that the TMR appears to have potential benefits in diseases that are mediated by both inflammation and oxidative stress and support the pharmacological basis of use of E. jambolana plant as traditional herbal medicine for the treatment of inflammatory diseases.

Rat Model of Cecal Ligation and Puncture versus Colon Ascendens Stent Peritonitis: Comparative Study for Oxidative Stress

“…However, the anti-oxidative T-SOD was decreased (P < 0.05), which was consistent with the previously published literature [22] [23]. Meanwhile, the oxidative stress condition in the CLP and CASP groups was similar within 72 hours, and there was no significant difference between the two groups regarding MDA and T-SOD levels (P > 0.05), but 72 hours later, it became greatly improved as shown by the decreased MDA (P < 0.05) and increased T-SOD in the CASP group (P < 0.05).…”

Anti‐Inflammatory Activities and Related Mechanism of Polysaccharides Isolated from Sargentodoxa cuneata

“…Carrageenan, an algal polysaccharide, can induce inflammatory reaction locally by releasing MDA, prostaglandins and other inflammatory mediators. [17] MDA is the product of lipid peroxidation, the main factor causing the damage of oxygen free radicals. It not only transforms the active oxygen into active lipid decomposition products, but also amplifies the role of reactive oxygen species, causing cell damage.…”

Anti-Inflammatory Activities of Kukoamine A From the Root Bark of Lycium chinense Miller

“…It acts by instigating the release of histamine, bradykinin, serotonin, and PGs leading to systemic or local inflammation. 18 As illustrated in Figure 5(a), the evidence of inflammatory reaction in the hind paw of the rats was observed after the subplantar injection of carrageenan. There was a marked increase in the paw volume with a peak value of 1.08 mL after 4 hours of carrageenan injection.…”