Beta-glucuronidase correlated with inflammation in the exudate from human gingiva

Bang, J.; Cimasoni, G.; Held, Arthur-Jean

doi:10.1016/0003-9969(70)90071-3

Cited by 56 publications

(14 citation statements)

References 11 publications

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“…non diabetic with chronic periodontitis (t=6.92, P < 0.001), as compared to healthy individuals, showing highly significant correlation between GCF β-glucuronidase level and probing pocket depth. These results are consistent with the findings of Bang et al [9] and Lamster et al . [10] These authors observed that β-glucuronidase increases with the development and severity of inflammation resulting into increased probing pocket depth and attachment loss.…”

Section: Discussionsupporting

confidence: 94%

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Comparative analysis of GCF β-glucuronidase level in diabetic and nondiabetic patients with chronic periodontitis: A clinicobiochemical study

Chowdhary

Gayathri

Mehta

2008

J Indian Soc Periodontol

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Recent evidences prove that, release of potent lysosomal enzymes e.g. β-Glucuronidase by degranulation of polymorponuclear leukocytes in host gingiva may contribute significantly to tissue destruction and the pathogenesis of periodontal disease. The purpose of the present study was to compare and correlate GCF β-Glucuronidase with periodontal status among diabetic and non-diabetic patients with chronic periodontitis. A total number of 75 patients were equally divided into Group I (control group), Group II (non diabetic with chronic periodontitis) and Group III (diabetic with chronic periodontitis). Clinical parameters like Plaque index, Gingival index, Probing Pocket Depth and RBS were recorded. The β-Glucuronidase level in GCF of all three groups was determined by spectrophotometric analysis. It was observed that the periodontitis patients irrespective of their diabetic status, showed increased periodontal destruction with elevated level of β-Glucuronidase than the controls. Also, the diabetic patients showed increased severity of periodontal destruction and the elevated level of β-Glucuronidase, thus indicating diabetics at a higher risk for progressive periodontal destruction.

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Section: Discussionsupporting

confidence: 94%

“…[9] In their study they observed that even in periodontally healthy individuals, some amount of subclinical inflammation was always present. Hence, in the present study, the presence of low levels of β-glucuronidase in Group I patients also indicates the presence of subclinical gingival inflammation.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of GCF β-glucuronidase level in diabetic and nondiabetic patients with chronic periodontitis: A clinicobiochemical study

Chowdhary

Gayathri

Mehta

2008

J Indian Soc Periodontol

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“…Inflammation could cause disequilibrium of the mutual dependence of metabolic and immune systems and then lead to chronic disorders of homeostasis. Beta-glucuronidase belonging to the disease class of normal mutation, which is generally known to be associated with inflammation in the exudates from gingival30. We therefore inferred the disease pair of normal variation and metabolic could be bridged by inflammation genes in proper conditions.…”

Section: Resultsmentioning

confidence: 99%

Network Analysis Reveals Functional Cross-links between Disease and Inflammation Genes

Zhang

Fan

et al. 2013

Sci Rep

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Connections between inflammation and diseases are suggested important in understanding the genetic mechanisms of diseases. However, studies on the functional cross-links between inflammation and disease genes are still in their early stages. We integrated the protein–protein interaction (PPI), inflammation genes, and gene–disease associations to construct a disease-inflammation network (DIN). We found that nodes, which are both inflammation and disease genes (namely inter-genes), are topologically important in the DIN structure. Via mapping inter-genes to PPI, we classified diseases into two categories, which are significantly different in Intimacy measuring the contribution of inflammation genes to the connections between disease pairs. Furthermore, we constructed a cross-talking subpathways network. As indicated, the cross-subpathway analysis shows great performance in capturing higher-level relationship among inflammation and disease processes. Collectively, The network-based analysis provides us a rather promising insight into the intricate relationship between inflammation and disease genes.

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“…5,[7][8][9][10] In fact, the relationship between βG activity and periodontal disease has been clearly shown. 5,[9][10][11][12][13][14][15] Furthermore, gingival crevicular fluid (GCF) βG activity might be a good indicator or predictor of periodontal disease activity [10][11][12][13] and its potential for indicating primary granular release from PMNs has been observed. 3 Periodontal diseases present significant hetereogenity in prevelance, severity, clinical course, and mode of treatment.…”

mentioning

confidence: 97%

“…[1][2][3] β-glucuronidase (βG) is an important component of the primary granules of PMN (also found in other cells and bacteria). [3][4][5] βG, together with hyaluronidase, is involved in the catabolism of proteoglycans. The endoglycosidase hyaluronidase cleaves hexosaminidic linkages, producing tetrasaccharides with the structure of (GlcUA-β1, 3-GlcNAc β1,4).…”

mentioning

confidence: 99%

Analysis of Human Gingival Tissue and Gingival Crevicular Fluid β‐Glucuronidase Activity in Specific Periodontal Diseases

Layik

Yamalik

Çağlayan

et al. 2000

Journal of Periodontology

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Beta-glucuronidase correlated with inflammation in the exudate from human gingiva

Cited by 56 publications

References 11 publications

Comparative analysis of GCF β-glucuronidase level in diabetic and nondiabetic patients with chronic periodontitis: A clinicobiochemical study

Comparative analysis of GCF β-glucuronidase level in diabetic and nondiabetic patients with chronic periodontitis: A clinicobiochemical study

Network Analysis Reveals Functional Cross-links between Disease and Inflammation Genes

Analysis of Human Gingival Tissue and Gingival Crevicular Fluid β‐Glucuronidase Activity in Specific Periodontal Diseases

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