and Ca overload, but had no effect on ATP content. Anoxia at pH 6.5 had no additional effect on Ca overload, but significantly reduced and glucose deprivation play only a minor role. The ER is the main source for this Ca rise. Ca overload is not readily reversible.i i
Medical ~c h o o~' b n i v . o f ~a p i 6 sThe effects of CT on small i n t e s t i n a l transport o f water and e l e c t r o l y t e s are well characterized. However, i t i s not known whether i o n and water transport a r e a l t e r e d i n the colon when CT i s present only i n the small intestine. Aiming a t defining t h e r o l e of t h e colon i n handling of water and e l e c t r o l y t e transport i n such circumstances, we have rreasured water and i o n transport i n v i v o i n r a t j e j u n a l and colonic separate loops. Two groups of r a t s were i n v e s t i g a t e d i n one CT (1 uglml) was i n s t i l l e d i n t h e j e j u n a l loop two hours before separate'perfusiin of both loops for the ensuing 3 hours w i t h a modified Ringer solution. the other ( c o n t r o l ) was likewise handled, but without any previous i n s t i l l a t i o n ' o f CT. Results:I n CT animals, water transport i n the jejunum was s i g n i f i c a n t l y (~( 0 . 0 1 ) toward secretion (-0.77t2.0 ul/min g wet weight vs. 13.19t1.9 i n the c o n t r o l s ) . Similarly, i n CT animals, t h e simultaneously measured water transport t o the colon was a l s o s i g n i f i c a n t l y (~( 0 . 0 1 ) s h i f t e d toward secretion (0.6+2,4 vs. 6.7t1.6 i n the c o n t r o l s ) . Na n e t transport p a r a l l e l e d these changes. I n conclusion: our data shows t h a t the colon contributes t o the o v e r a l l i n t e s t i n a l secretion seen i n cholera i n f e c t i o n even when CT does not i n t e r a c t w i t h i t s mucasa. I t remains t o be seen wheth:r such observation r e l a t e s only t o CT-elicited small i n t e s t i n a l secretion or i t represents a general p a t t e r n l i n k i n g small and l a r g e i n t e s t i n a l transport. to ensure continued synthesis of vital proteins; concomitantly, after a transient breakdown of mRNA leading to increased m7tiua excretion whole-body mRNA turnover is slowed down. Our results demonstrate that m3His and m7Gua excretion move in opposlte directions with decreasing food intakes. Therefore increased m3~is/ m7Gua ratios, which can be measured in spot urine samples, may turn out to be a valuable noninvasive indicator of catabolism caused by food deficiency. Ihe benefit of a hyperalimentation in patients with cystic fibrosis is well known. Oral hyperalimentation is difficult to perform and gastric tubes are not well accepted by the patients. In a prospective study we investigated whether PEG might be an alternative in the application of hypercaloric diet. So far PEG was performed in 9 children aged from 7,2 to 17,9 years. In 8 patients we have a follow-up of at least 3 months. Those patients entered the study where there was 1. a percentage ideal weight for height (IWH) below 80% 2. and/or no improvement of the IWH above 3% despite optimal conventional nutrition in a 6 month period. PEG was performed under general anaesthesia according to the method of Keymlingo. Except of two dislocations of the PEG-tube, which were easily corrected, we saw no complica...
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