Beta-Glucan From Barley Attenuates Post-prandial Glycemic Response by Inhibiting the Activities of Glucose Transporters but Not Intestinal Brush Border Enzymes and Amylolysis of Starch

Malunga, Lovemore Nkhata; Ames, Nancy; Zhouyao, Haonan; Blewett, Heather; Thandapilly, Sijo Joseph

doi:10.3389/fnut.2021.628571

Cited by 13 publications

(8 citation statements)

References 29 publications

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“…The obtained results are similar to Malunga et al, (2021) who studied his mechanism through which BG from barley affects post-prandial glycemic response. Waffles containing 0, 1, 2, and 3 g barley BG and the same amount of available carbohydrate (15 g) were fed to the TIM-1 dynamic gastrointestinal digestion system to study the effect of BG on starch hydrolysis.…”

Section: Glucose Contentsupporting

confidence: 87%

Studying the Effect of Fennel and Barley Seeds in Mitigation Kidney Disease of Rats

El-Sayed

Khafagy

Erakey

2023

Menoufia Journal of Food and Dairy Sciences

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This study aims to investigate the effect of fennel and barley seeds on 24 rats with inflicted kidneys weighing 150 ± 10g. Rats were fed on basal diet for 7 consecutive days on basal diet, then divided into 6 groups each of 4 rats. The first was negative control group fed on the basal diet, and the second was positive group injected with gentamicin (10 mg/kg body weight) twice a week for four weeks. As for the other groups, rats treated with 5%, 10%, fennel seeds (FS) and 5%, 10% barley seeds (BS). After twice a week for four weeks of the experiment, rats weight was measured, blood samples were taken for biochemical analysis. Fennel seeds (FS) 10% has best effect in lowering glucose, barley 10% improved enzyme activity Alanine transform (ALT) and fennel 5% improved high-density cholesterol (HDL-C). Barley seeds (BS) 10% has best effect on lowering triglycerides, barley 5% improved low-density lipoprotein and activity of creatinine and urea. Barley seeds (BS) 10% has best effect in lowering activity of total cholesterol and barley 5% acted better in decreasing activity of liver enzymes alkaline phosphatase and glutamic-oxaloacetic transaminase (ALP, AST). The histological investigation confirmed the fact that treatments with fennel and barley seeds mitigation the kidneys and livers diseases. Fennel and barley seeds has good effects on liver and kidney functions, glucose and lipid levels.

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Section: Glucose Contentsupporting

confidence: 87%

Studying the Effect of Fennel and Barley Seeds in Mitigation Kidney Disease of Rats

El-Sayed

Khafagy

Erakey

2023

Menoufia Journal of Food and Dairy Sciences

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“…These data may suggest that women demonstrated improved glucose tolerance following dietary fiber supplement. Moreover, a plethora of research has demonstrated that the mechanisms of glycemic control by fiber are strongly associated with the two predominant physicochemical properties of viscosity and fermentability ( Gill et al, 2021 ; Malunga et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

The effect of dietary fiber supplement on prevention of gestational diabetes mellitus in women with pre-pregnancy overweight/obesity: A randomized controlled trial

Zhang

Cheng²,

Cao³

et al. 2022

Front. Pharmacol.

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Objective: To investigate the effect of dietary fiber intake during pregnancy on the prevention of gestational diabetes mellitus (GDM) in women who are overweight/obese prior to pregnancy.Methods: This randomized controlled trial was conducted in Shanghai General Hospital from June 2021 to March 2022. A total of 98 women who reported BMI≥24 kg/m2 prior to pregnancy were recruited before their 20th gestational week, and randomly (simple random allocation) assigned to the fiber supplement group (12 g of dietary fiber power twice daily) and the control group (standard prenatal care) from 20 to 24+6 gestational weeks. Both groups received nutrition education and dietary advice during the study. GDM diagnosis was performed by an oral glucose tolerance test (OGTT) at 25–28 weeks’ gestation. Data are presented as means with SD, as medians with IQR, or as counts with percentages as appropriate. Comparisons were conducted using a t-test, Mann-Whitney U test, and χ2 test, respectively.Results: The incidence of GDM was significantly reduced in the fiber supplement group compared with the control group: 8.3 vs. 24.0% (χ2 = 4.40, p = 0.036). At OGTT, the mean fasting plasma glucose in the fiber supplement group was significantly lower than before the intervention (4.57 ± 0.38 mmol/L vs. 4.41 ± 0.29 mmol/L, p < 0.01) but not in the control group (4.48 ± 0.42 mmol/L vs. 4.37 ± 0.58 mmol/L, p = 0.150). Compared with the control group, the TG and TG/HDL-C ratio levels in the intervention group were significantly higher than those in the control group (2.19 ± 0.54 mmol/L vs. 2.70 ± 0.82 mmol/L and 1.19 ± 0.49 vs.1.63 ± 0.63, respectively, all P＜0.05). The body weight gain was significantly lower in the fiber supplement group than the control group (1.99 ± 1.09 kg vs. 2.53 ± 1.20kg, p = 0.022). None of the women randomized to the fiber supplement group experienced preterm birth (<37 weeks gestation) compared with 12.0% in the control group (p = 0.040). Excessive weight gain (total weight gain >11.5 kg for overweight, and >9.0 kg for obesity) occurred in 46.7% of women in the fiber supplement group compared with 68.0% in the control group (p = 0.035). There were no differences in other maternal and neonatal outcomes.Conclusion: Increased dietary fiber intake in pregnant women who were overweight/obese prior to pregnancy may reduce the risk of GDM, excessive weight gain, and preterm birth, but it did not improve blood lipids.

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“…Our results suggested that the jejunal expression of GLUT2 and SGLT1 was increased in the 500 mg/kg pancreatin group compared with the control group. Both GLUT2 and SGLT1 expressions on the intestinal brush border layer are dependent on the luminal glucose concentration ( Malunga et al, 2021 ). Presumably, the increased mRNA expression observed in the current study was a consequence of the addition of 500 mg/kg pancreatin.…”

Section: Discussionmentioning

confidence: 99%

The Positive Effects of Exogenous Pancreatin on Growth Performance, Nutrient Digestion and Absorption, and Intestinal Microbiota in Piglets

Liu

Huang

et al. 2022

Front. Physiol.

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Pancreatin secretion is dramatically decreased over time after weaning, thus affecting the utilization of nutrients in piglets. Therefore, exogenous pancreatin is expected to alleviate this situation. This experiment was conducted to investigate the effects of exogenous pancreatin on the growth performance, nutrient digestion and absorption, and intestinal microbiota of piglets. One hundred eighty piglets (Duroc × Landrace × Yorkshire, 40 days) were randomly allotted to three treatments (basal diets supplemented with 0, 250, or 500 mg/kg pancreatin) with three replicate pens per treatment and 20 piglets per pen. Compared with the control diet, dietary 500 mg/kg pancreatin significantly increased (p < 0.05) the average daily gain (ADG) and the apparent digestibility of crude protein and crude fat of piglets. Regarding endogenous enzymes, pancrelipase activity in the pancreas, duodenal mucosa, and small intestinal digesta as well as trypsin activity in the jejunal digesta were increased in piglets fed a diet supplemented with 500 mg/kg pancreatin (p < 0.05). Moreover, amylopsin activity was significantly strengthened in the pancreas, duodenal mucosa, and digesta in piglets fed a diet with 500 mg/kg pancreatin (p < 0.05). The mRNA expression of nutrient transporters, including oligopeptide transporter-1 (PepT1), excitatory amino acid transporter-1 (EAAC1), cationic amino acid transporter-1 (CAT1), sodium glucose cotransporter-1 (SGLT1), glucose transporter-2 (GLUT2), and fatty acid transporter-4 (FATP4), in the jejunum significantly increased after dietary supplementation with 500 mg/kg pancreatin (p < 0.05). An increased villus height-to-crypt depth ratio of the ileum was observed in the 500 mg/kg pancreatin-treated group (p < 0.05). The composition of the colonic microbiota modulated by the addition of 500 mg/kg pancreatin was characterized by an increased relative abundance of Lactobacillus (p < 0.05), and the predicted functions revealed that 500 mg/kg pancreatin supplementation enhanced the functional abundance of genetic information processing in colonic microorganisms and environmental information processing. Our findings suggested that the addition of 500 mg/kg pancreatin improved the growth performance of piglets, improved intestinal structure, and modulated the colon microbiota, thereby increasing nutrient digestibility.

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Beta-Glucan From Barley Attenuates Post-prandial Glycemic Response by Inhibiting the Activities of Glucose Transporters but Not Intestinal Brush Border Enzymes and Amylolysis of Starch

Cited by 13 publications

References 29 publications

Studying the Effect of Fennel and Barley Seeds in Mitigation Kidney Disease of Rats

Studying the Effect of Fennel and Barley Seeds in Mitigation Kidney Disease of Rats

The effect of dietary fiber supplement on prevention of gestational diabetes mellitus in women with pre-pregnancy overweight/obesity: A randomized controlled trial

The Positive Effects of Exogenous Pancreatin on Growth Performance, Nutrient Digestion and Absorption, and Intestinal Microbiota in Piglets

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